Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction

Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature

(2018) Wendy Klement et al.   NEUROBIOLOGY OF DISEASE

Seizure epicenter depth and translaminar field potential synchrony underlie complex variations in tissue oxygenation during ictal initiation

(2018) Samuel S. Harris et al.   NEUROIMAGE

Topographic Reorganization of Cerebrovascular Mural Cells under Seizure Conditions

(2018) Margarita Arango-Lievano et al.   Cell Reports

Postictal hypoperfusion/hypoxia provides the foundation for a unified theory of seizure-induced brain abnormalities and behavioral dysfunction

(2017) Jordan S. Farrell et al.   EPILEPSIA

Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro

(2017) Karl Schoknecht et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascular Pericyte Impairment and Connexin43 Gap Junction Deficit Contribute to Vasomotor Decline in Diabetic Retinopathy

(2017) Elena Ivanova et al.   JOURNAL OF NEUROSCIENCE

Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow

(2017) Thomas A Longden et al.   NATURE NEUROSCIENCE

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy

(2017) Rocio Leal-Campanario et al.   Scientific Reports

Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery

(2016) U. Vazana et al.   JOURNAL OF NEUROSCIENCE

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Comorbidities of epilepsy: current concepts and future perspectives

(2016) Mark R Keezer et al.   LANCET NEUROLOGY

Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent

(2016) Jordan S Farrell et al.   eLife

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia

(2015) Francisco Fernandez-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

PDGFRβ+ cells in human and experimental neuro-vascular dysplasia and seizures

(2015) R. Garbelli et al.   NEUROSCIENCE

Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke

(2015) Ying Bai et al.   PLoS One

Losartan prevents acquired epilepsy via TGF-β signaling suppression

(2014) Guy Bar-Klein et al.   ANNALS OF NEUROLOGY

Monitoring Stroke Progression: In Vivo Imaging of Cortical Perfusion, Blood—Brain Barrier Permeability and Cellular Damage in the Rat Photothrombosis Model

(2014) Karl Schoknecht et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Oxygen and seizure dynamics: I. Experiments

(2014) Justin Ingram et al.   JOURNAL OF NEUROPHYSIOLOGY

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Redistribution of PDGFRβ cells and NG2DsRed pericytes at the cerebrovasculature after status epilepticus

(2014) Sebastien Milesi et al.   NEUROBIOLOGY OF DISEASE

Role of blood–brain barrier in temporal lobe epilepsy and pharmacoresistance

(2014) E.A. van Vliet et al.   NEUROSCIENCE

The Effects of Focal Epileptic Activity on Regional Sensory-Evoked Neurovascular Coupling and Postictal Modulation of Bilateral Sensory Processing

(2013) Sam Harris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Stimulation of the Sphenopalatine Ganglion Induces Reperfusion and Blood-Brain Barrier Protection in the Photothrombotic Stroke Model

(2012) Haviv Levi et al.   PLoS One

Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: A puzzle of a chicken and egg?

(2011) Alon Friedman   EPILEPSIA

Preictal and Ictal Neurovascular and Metabolic Coupling Surrounding a Seizure Focus

(2011) M. Zhao et al.   JOURNAL OF NEUROSCIENCE

Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling Pathways

(2011) M. Morin-Brureau et al.   JOURNAL OF NEUROSCIENCE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Preservation of transendothelial glucose transporter 1 and P-glycoprotein transporters in a cortical slice culture model of the blood–brain barrier

(2010) R.S. Camenzind et al.   NEUROSCIENCE

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

(2010) F. Fernandez-Klett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction

(2010) Hélène Girouard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent Increase in Oxygen Consumption and Impaired Neurovascular Coupling after Spreading Depression in Rat Neocortex

(2009) Henning Piilgaard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

Dynamic in vivo imaging of cerebral blood flow and blood–brain barrier permeability

(2009) Ofer Prager et al.   NEUROIMAGE

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE