Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets
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Title
Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets
Authors
Keywords
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Journal
Brain Sciences
Volume 9, Issue 11, Pages 318
Publisher
MDPI AG
Online
2019-11-12
DOI
10.3390/brainsci9110318
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Note: Only part of the references are listed.- High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: From pathogenesis to therapeutic approaches
- (2019) Yam Nath Paudel et al. JOURNAL OF NEUROCHEMISTRY
- Repetitive Diffuse Mild Traumatic Brain Injury Causes an Atypical Astrocyte Response and Spontaneous Recurrent Seizures
- (2019) Oleksii Shandra et al. JOURNAL OF NEUROSCIENCE
- Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems
- (2019) Rishabh Sharma et al. BRAIN BEHAVIOR AND IMMUNITY
- Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus
- (2019) Lijie Feng et al. GLIA
- The Role of Chemokines in the Pathophysiology of Major Depressive Disorder
- (2019) Vladimir M. Milenkovic et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences
- (2019) Kyria M. Webster et al. EXPERIMENTAL NEUROLOGY
- Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy
- (2018) Dan Xu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neutrophils in traumatic brain injury (TBI): friend or foe?
- (2018) Yang-Wuyue Liu et al. Journal of Neuroinflammation
- Systemic autoinflammation with intractable epilepsy managed with interleukin-1 blockade
- (2018) Allen D. DeSena et al. Journal of Neuroinflammation
- Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy
- (2018) Ralf G. Rempe et al. JOURNAL OF NEUROSCIENCE
- In search of antiepileptogenic treatments for post-traumatic epilepsy
- (2018) Patricia G. Saletti et al. NEUROBIOLOGY OF DISEASE
- Breakdown of blood brain barrier as a mechanism of post-traumatic epilepsy
- (2018) Aaron Dadas et al. NEUROBIOLOGY OF DISEASE
- Protein biomarkers of epileptogenicity after traumatic brain injury
- (2018) Denes V. Agoston et al. NEUROBIOLOGY OF DISEASE
- Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy
- (2018) Xiaofeng Zhao et al. Cell Reports
- Microglia after Seizures and in Epilepsy
- (2018) Toshimitsu Hiragi et al. Cells
- Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage
- (2018) Inken Waltl et al. BRAIN BEHAVIOR AND IMMUNITY
- Epidemiology of traumatic brain injury-associated epilepsy and early use of anti-epilepsy drugs: An analysis of insurance claims data, 2004–2014
- (2018) Xinyao DeGrauw et al. EPILEPSY RESEARCH
- Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures
- (2018) Christopher Käufer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis
- (2018) Ljiljana Nikolic et al. GLIA
- Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice
- (2018) Kyria M. Webster et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium-pilocarpine-induced status epilepticus
- (2018) Ya-jun Li et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Chemokines as new inflammatory players in the pathogenesis of epilepsy
- (2017) Chiara Cerri et al. EPILEPSY RESEARCH
- Nonclassical Monocytes Mediate Secondary Injury, Neurocognitive Outcome, and Neutrophil Infiltration after Traumatic Brain Injury
- (2017) Hadijat M. Makinde et al. JOURNAL OF IMMUNOLOGY
- Inflammation in epileptogenesis after traumatic brain injury
- (2017) Kyria M. Webster et al. Journal of Neuroinflammation
- Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus
- (2017) Dai-Shi Tian et al. JOURNAL OF NEUROSCIENCE
- Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain
- (2017) Bridgette D. Semple et al. JOURNAL OF NEUROSCIENCE
- Converging early responses to brain injury pave the road to epileptogenesis
- (2017) Eric J. Neuberger et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy
- (2017) Valentina Iori et al. NEUROBIOLOGY OF DISEASE
- Microglial positron emission tomography (PET) imaging in epilepsy: Applications, opportunities and pitfalls
- (2017) Gregory Scott et al. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- Febrile infection-related epilepsy syndrome treated with anakinra
- (2016) Daniel L. Kenney-Jung et al. ANNALS OF NEUROLOGY
- Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation
- (2016) Liudmila Efremova et al. ARCHIVES OF TOXICOLOGY
- Quinolinic acid neurotoxicity: Differential roles of astrocytes and microglia via FGF-2-mediated signaling in redox-linked cytoskeletal changes
- (2016) Paula Pierozan et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Modulation of neuronal excitability by immune mediators in epilepsy
- (2016) Valentina Iori et al. CURRENT OPINION IN PHARMACOLOGY
- Incidence and risk factors of posttraumatic seizures following traumatic brain injury: A Traumatic Brain Injury Model Systems Study
- (2016) Anne C. Ritter et al. EPILEPSIA
- Anti-tumor necrosis factor alpha therapy (adalimumab) in Rasmussen's encephalitis: An open pilot study
- (2016) Stanislas Lagarde et al. EPILEPSIA
- Microglia-Neuron Communication in Epilepsy
- (2016) Ukpong B. Eyo et al. GLIA
- Changes in serum albumin levels and neutrophil–lymphocyte ratio in patients with convulsive status epilepticus
- (2016) Hasan H Özdemir et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Higher expression of monocyte chemoattractant protein 1 and its receptor in brain tissue of intractable epilepsy patients
- (2016) Chunyan Wang et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Neuroinflammation: the devil is in the details
- (2016) Damon J. DiSabato et al. JOURNAL OF NEUROCHEMISTRY
- The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation
- (2016) Chiara Cerri et al. JOURNAL OF NEUROSCIENCE
- Serial Quantitative TSPO-Targeted PET Reveals Peak Microglial Activation up to 2 Weeks After an Epileptogenic Brain Insult
- (2016) M. Brackhan et al. JOURNAL OF NUCLEAR MEDICINE
- Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy
- (2016) Xueqin Wang et al. MOLECULAR NEUROBIOLOGY
- Inflammatory mediators in human epilepsy: A systematic review and meta-analysis
- (2016) Evelien E. de Vries et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Astroglial Scarring and Seizures
- (2016) Stefanie Robel NEUROSCIENTIST
- Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus
- (2016) Nicholas H. Varvel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neurorestoration after traumatic brain injury through angiotensin II receptor blockage
- (2015) Sonia Villapol et al. BRAIN
- Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?
- (2015) Zhi-Gang Ji et al. BRAIN RESEARCH BULLETIN
- Posttraumatic seizures and epilepsy in adult rats after controlled cortical impact
- (2015) Kevin M. Kelly et al. EPILEPSY RESEARCH
- Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging
- (2015) Akihiro Matsumura et al. FREE RADICAL BIOLOGY AND MEDICINE
- Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures
- (2015) Gabriel M. Arisi et al. Journal of Neuroinflammation
- Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction
- (2015) Itai Weissberg et al. NEUROBIOLOGY OF DISEASE
- Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis
- (2015) Halima Amhaoul et al. NEUROBIOLOGY OF DISEASE
- Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus
- (2015) N. Wang et al. NEUROSCIENCE
- Immune Surveillance of the CNS following Infection and Injury
- (2015) Matthew V. Russo et al. TRENDS IN IMMUNOLOGY
- Role of Astrocytes in Epilepsy
- (2015) D. A. Coulter et al. Cold Spring Harbor Perspectives in Medicine
- Inflammation and Neuroprotection in Traumatic Brain Injury
- (2015) Kara N. Corps et al. JAMA Neurology
- Blood Biomarkers in Moderate-To-Severe Traumatic Brain Injury: Potential Utility of a Multi-Marker Approach in Characterizing Outcome
- (2015) Alex P. Di Battista et al. Frontiers in Neurology
- Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2
- (2015) Deepti Chugh et al. PLoS One
- Losartan prevents acquired epilepsy via TGF-β signaling suppression
- (2014) Guy Bar-Klein et al. ANNALS OF NEUROLOGY
- AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease
- (2014) Tz-Chuen Ju et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Glycyrrhizin Suppresses HMGB1 Inductions in the Hippocampus and Subsequent Accumulation in Serum of a Kainic Acid-Induced Seizure Mouse Model
- (2014) Lidan Luo et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control
- (2014) David Cantu et al. CEREBRAL CORTEX
- IL-1β associations with posttraumatic epilepsy development: A genetics and biomarker cohort study
- (2014) Matthew L. Diamond et al. EPILEPSIA
- Pattern recognition receptors and central nervous system repair
- (2014) Kristina A. Kigerl et al. EXPERIMENTAL NEUROLOGY
- Abnormal microglial activation in theCstb−/−mouse, a model for progressive myoclonus epilepsy, EPM1
- (2014) Olesya Okuneva et al. GLIA
- Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells
- (2014) Rita Perfeito et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Phagocytosis of Microglia in the Central Nervous System Diseases
- (2014) Ruying Fu et al. MOLECULAR NEUROBIOLOGY
- Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy
- (2014) Jana D. Tchekalarova et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Targeting inflammation as a therapeutic strategy for drug-resistant epilepsies
- (2014) Giovanna Vitaliti et al. Human Vaccines & Immunotherapeutics
- Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons
- (2013) Silvia Balosso et al. ANTIOXIDANTS & REDOX SIGNALING
- Early down regulation of the glial Kir4.1 and GLT-1 expression in pericontusional cortex of the old male mice subjected to traumatic brain injury
- (2013) R. K. Gupta et al. BIOGERONTOLOGY
- PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy
- (2013) Stefanie Dedeurwaerdere et al. EJNMMI Research
- The Role of Markers of Inflammation in Traumatic Brain Injury
- (2013) Thomas Woodcock et al. Frontiers in Neurology
- Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)
- (2012) Meir Bialer et al. EPILEPSY RESEARCH
- Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy
- (2012) Uwe Heinemann et al. GLIA
- Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus
- (2012) Ji-Eun Kim et al. Journal of Neuroinflammation
- Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy
- (2012) M. Nowak et al. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
- IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures
- (2011) Annamaria Vezzani et al. BRAIN BEHAVIOR AND IMMUNITY
- Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy
- (2011) Y. Wu et al. CLINICAL NEUROPATHOLOGY
- Etiologies of epilepsy: a comprehensive review
- (2011) Devender Bhalla et al. Expert Review of Neurotherapeutics
- Regulation of the Inflammatory Response: Enhancing Neutrophil Infiltration under Chronic Inflammatory Conditions
- (2011) Z. Bian et al. JOURNAL OF IMMUNOLOGY
- Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy
- (2011) M. Zattoni et al. JOURNAL OF NEUROSCIENCE
- Adoptive transfer of T lymphocytes in immunodeficient mice influences epileptogenesis and neurodegeneration in a model of temporal lobe epilepsy
- (2011) Francine Deprez et al. NEUROBIOLOGY OF DISEASE
- Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice
- (2011) Mattia Maroso et al. Neurotherapeutics
- Correction: Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins
- (2011) Saran Feng et al. PLoS One
- Regulation of interleukin-1 in acute brain injury
- (2011) David Brough et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Aquaporin 4 expression in control and epileptic human cerebral cortex
- (2010) Valentina Medici et al. BRAIN RESEARCH
- Role of CCL2 (MCP-1) in Traumatic Brain Injury (TBI): Evidence from Severe TBI Patients and CCL2−/− Mice
- (2010) Bridgette D Semple et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Chemokine CCL2 modulation of neuronal excitability and synaptic transmission in rat hippocampal slices
- (2010) Yan Zhou et al. JOURNAL OF NEUROCHEMISTRY
- The emerging role for chemokines in epilepsy
- (2010) Paolo F. Fabene et al. JOURNAL OF NEUROIMMUNOLOGY
- CCL2 modulates cytokine production in cultured mouse astrocytes
- (2010) Bridgette D Semple et al. Journal of Neuroinflammation
- Spontaneous Epileptiform Activity in Rat Neocortex after Controlled Cortical Impact Injury
- (2010) Lie Yang et al. JOURNAL OF NEUROTRAUMA
- The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights
- (2010) Agnes E. Coutinho et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
- (2010) Mattia Maroso et al. NATURE MEDICINE
- Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury
- (2010) Dan Shlosberg et al. Nature Reviews Neurology
- The role of inflammation in epilepsy
- (2010) Annamaria Vezzani et al. Nature Reviews Neurology
- Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury
- (2010) S. Nag et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Astrocyte dysfunction in epilepsy
- (2009) Gerald Seifert et al. BRAIN RESEARCH REVIEWS
- A population-based study of risk of epilepsy after hospitalization for traumatic brain injury
- (2009) Pamela L. Ferguson et al. EPILEPSIA
- Epilepsy after head injury: An overview
- (2009) Daniel H. Lowenstein EPILEPSIA
- A potential model of pediatric posttraumatic epilepsy
- (2009) K.D. Statler et al. EPILEPSY RESEARCH
- Blood–brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy
- (2009) Alon Friedman et al. EPILEPSY RESEARCH
- Involvement of ROS in BBB dysfunction
- (2009) Pamela B. L. Pun et al. FREE RADICAL RESEARCH
- Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks
- (2009) Bridgette D Semple et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury
- (2009) Tony Frugier et al. JOURNAL OF NEUROTRAUMA
- The bright side of the glial scar in CNS repair
- (2009) Asya Rolls et al. NATURE REVIEWS NEUROSCIENCE
- Neutrophil elastase and neurovascular injury following focal stroke and reperfusion
- (2009) Ann M. Stowe et al. NEUROBIOLOGY OF DISEASE
- Molecular and functional interactions between tumor necrosis factor-alpha receptors and the glutamatergic system in the mouse hippocampus: Implications for seizure susceptibility
- (2009) S. Balosso et al. NEUROSCIENCE
- IL-6 Mediated Degeneration of Forebrain GABAergic Interneurons and Cognitive Impairment in Aged Mice through Activation of Neuronal NADPH Oxidase
- (2009) Laura L. Dugan et al. PLoS One
- Interleukin-10 is associated with resistance to febrile seizures: Genetic association and experimental animal studies
- (2008) Yoshito Ishizaki et al. EPILEPSIA
- Strategies for use of IL-10 or its antagonists in human disease
- (2008) Anne O'Garra et al. IMMUNOLOGICAL REVIEWS
- Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines
- (2008) Britta Engelhardt JOURNAL OF THE NEUROLOGICAL SCIENCES
- Moderate and severe traumatic brain injury in adults
- (2008) Andrew IR Maas et al. LANCET NEUROLOGY
- Interleukin-6 and Neural Stem Cells: More Than Gliogenesis
- (2008) Omedul Islam et al. MOLECULAR BIOLOGY OF THE CELL
- Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK
- (2008) Xiao-Qin Wang et al. NEUROSCIENCE LETTERS
- TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury
- (2008) E. Taoufik et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blood-brain barrier disruption in post-traumatic epilepsy
- (2007) O Tomkins et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- The role of inflammation in CNS injury and disease
- (2006) Sian-Marie Lucas et al. BRITISH JOURNAL OF PHARMACOLOGY
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