microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches

Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage

(2017) Qian He et al.   GLIA

Small RNA sequencing revealed dysregulated piRNAs in Alzheimer's disease and their probable role in pathogenesis

(2017) Jyoti Roy et al.   Molecular BioSystems

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA biomarkers of Parkinson’s disease in serum exosome-like microvesicles

(2017) Xiang-Yang Cao et al.   NEUROSCIENCE LETTERS

The science and ethics of cell-based therapies for Parkinson's disease

(2017) C.R. Towns   PARKINSONISM & RELATED DISORDERS

MicroRNAs underlying memory deficits in neurodegenerative disorders

(2017) Julia Hernandez-Rapp et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Targets and Mechanisms in Prevention of Parkinson's Disease through Immunomodulatory Treatments

(2017) M. von Euler Chelpin et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Dicer and microRNAs protect adult dopamine neurons

(2017) Piotr Chmielarz et al.   Cell Death & Disease

MicroRNA-4639 Is a Regulator of DJ-1 Expression and a Potential Early Diagnostic Marker for Parkinson’s Disease

(2017) Yimeng Chen et al.   Frontiers in Aging Neuroscience

A Guide to Approaching Regulatory Considerations for Lentiviral-Mediated Gene Therapies

(2017) Michael White et al.   Human Gene Therapy Methods

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of LRRK2 in the regulation of dopamine receptor trafficking

(2017) Mauro Rassu et al.   PLoS One

Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease

(2016) Yuejun Chen et al.   Cell Stem Cell

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

(2016) Débora Vieira et al.   International Journal of Nanomedicine

MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease

(2016) C. Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease

(2016) Aaron D. Thome et al.   JOURNAL OF NEUROSCIENCE

miRNAs as Circulating Biomarkers for Alzheimer's Disease and Parkinson's Disease

(2016) Gohar Mushtaq et al.   Medicinal Chemistry

MicroRNAs in Cerebrospinal Fluid as Potential Biomarkers for Parkinson’s Disease and Multiple System Atrophy

(2016) Tainá M. Marques et al.   MOLECULAR NEUROBIOLOGY

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Levodopa therapy for Parkinson disease: Table

(2016) Peter A. LeWitt et al.   NEUROLOGY

Alterations of miRNAs reveal a dysregulated molecular regulatory network in Parkinson’s disease striatum

(2016) Venugopalan D. Nair et al.   NEUROSCIENCE LETTERS

Identification of a panel of five serum miRNAs as a biomarker for Parkinson's disease

(2016) Haixia Ding et al.   PARKINSONISM & RELATED DISORDERS

Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications

(2016) Simon Schafferer et al.   PLoS One

microRNA Profiles in Parkinson's Disease Prefrontal Cortex

(2016) Andrew G. Hoss et al.   Frontiers in Aging Neuroscience

Optimizing Transgene Configuration and Protein Fusions to Maximize Dopamine Production for the Gene Therapy of Parkinson's Disease

(2016) Hannah J. Stewart et al.   Human Gene Therapy Clinical Development

MicroRNA association with synucleinopathy conversion in rapid eye movement behavior disorder

(2015) Rubén Fernández-Santiago et al.   ANNALS OF NEUROLOGY

Memory formation and retention are affected in adult miR-132/212 knockout mice

(2015) Julia Hernandez-Rapp et al.   BEHAVIOURAL BRAIN RESEARCH

TNF-α regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells

(2015) Paresh Prajapati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A panel of four decreased serum microRNAs as a novel biomarker for early Parkinson’s disease

(2015) Hui Dong et al.   BIOMARKERS

MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim

(2015) Huiqing Wang et al.   BRAIN PATHOLOGY

Midbrain dopamine neurons in Parkinson׳s disease exhibit a dysregulated miRNA and target-gene network

(2015) Christine E. Briggs et al.   BRAIN RESEARCH

MicroRNA-7: a promising new target in cancer therapy

(2015) Juanjuan Zhao et al.   Cancer Cell International

MicroRNA-155 Promotes Atherosclerosis Inflammation via Targeting SOCS1

(2015) Yang Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregationin vivo

(2015) Pascal Y. Smith et al.   HUMAN MOLECULAR GENETICS

MicroRNA Therapeutics: the Next Magic Bullet?

(2015) Bridget Simonson et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Overexpression of blood microRNAs 103a, 30b, and 29a in L-dopa-treated patients with PD

(2015) A. Serafin et al.   NEUROLOGY

miRNA expression is highly sensitive to a drug therapy in Parkinson's disease

(2015) Anelya Kh. Alieva et al.   PARKINSONISM & RELATED DISORDERS

The Landscape of long noncoding RNA classification

(2015) Georges St. Laurent et al.   TRENDS IN GENETICS

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Progresses towards safe and efficient gene therapy vectors

(2015) Sergiu Chira et al.   Oncotarget

Understanding the Effect of Locked Nucleic Acid and 2′-O-Methyl Modification on the Hybridization Thermodynamics of a miRNA–mRNA Pair in the Presence and Absence of AfPiwi Protein

(2014) Santosh Kumar et al.   BIOCHEMISTRY

Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease

(2014) Savan Kabaria et al.   FEBS LETTERS

The screening of the 3′UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson’s disease

(2014) Lucía F Cardo et al.   JOURNAL OF HUMAN GENETICS

MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects

(2014) Lucía F. Cardo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

MicroRNA-7 Protects against 1-Methyl-4-Phenylpyridinium-Induced Cell Death by Targeting RelA

(2014) D. C. Choi et al.   JOURNAL OF NEUROSCIENCE

Identification of blood serum micro-RNAs associated with idiopathic andLRRK2Parkinson's disease

(2014) Teresa Botta-Orfila et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

(2014) Stéphane Palfi et al.   LANCET

Altered Expression of miR-202 in Cerebellum of Multiple-System Atrophy

(2014) Soon-Tae Lee et al.   MOLECULAR NEUROBIOLOGY

The role of the LRRK2 gene in Parkinsonism

(2014) Jie-Qiong Li et al.   Molecular Neurodegeneration

MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

(2014) Christopher J. Cheng et al.   NATURE

miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling

(2014) Woori Kim et al.   NEUROBIOLOGY OF AGING

Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease

(2014) Falk Schlaudraff et al.   NEUROBIOLOGY OF AGING

Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins

(2014) N. Kanagaraj et al.   NEUROSCIENCE

Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology

(2014) Kasandra Burgos et al.   PLoS One

miR-16-1 Promotes the Aberrantα-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70

(2014) Zhelin Zhang et al.   TheScientificWorldJOURNAL

Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy

(2014) Annamaria Vallelunga et al.   Frontiers in Cellular Neuroscience

miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway

(2014) Apostolia Fragkouli et al.   Frontiers in Cellular Neuroscience

Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson's Leukocytes Identified by RNA Sequencing

(2014) Lilach Soreq et al.   PLoS Computational Biology

Therapeutic prospects for Parkinson disease

(2013) C. Warren Olanow et al.   ANNALS OF NEUROLOGY

MicroRNAs in Immune Response and Macrophage Polarization

(2013) Gang Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects

(2013) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls

(2013) Lucía F. Cardo et al.   JOURNAL OF NEUROLOGY

Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival

(2013) Xueyan Pang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

MicroRNA-494 reduces DJ-1 expression and exacerbates neurodegeneration

(2013) Ran Xiong et al.   NEUROBIOLOGY OF AGING

Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo

(2013) F. Billia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paths from Pesticides to Parkinson's

(2013) F. Kamel   SCIENCE

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation

(2013) C Parisi et al.   Cell Death & Disease

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Parkinsonism Due to Mutations in PINK1, Parkin, and DJ-1 and Oxidative Stress and Mitochondrial Pathways

(2013) M. R. Cookson   Cold Spring Harbor Perspectives in Medicine

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Association Between Early-Onset Parkinson Disease and 22q11.2 Deletion Syndrome

(2013) Nancy J. Butcher et al.   JAMA Neurology

Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes

(2013) Lilach Soreq et al.   Frontiers in Molecular Neuroscience

Glia as a Turning Point in the Therapeutic Strategy of Parkinsons Disease

(2012) Francesca L'Episcopo et al.   CNS & Neurological Disorders-Drug Targets

SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression

(2012) Loredana Zocchi et al.   Epigenetics

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein

(2012) Hyun Jin Cho et al.   HUMAN MOLECULAR GENETICS

miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression

(2012) D. Yang et al.   JOURNAL OF CELL SCIENCE

Normal Midbrain Dopaminergic Neuron Development and Function in miR-133b Mutant Mice

(2012) M. P. Heyer et al.   JOURNAL OF NEUROSCIENCE

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

(2012) M. Akerblom et al.   JOURNAL OF NEUROSCIENCE

Pathogenesis of Parkinson's disease

(2012) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

Gene–environment interactions in Parkinson's disease: Specific evidence in humans and mammalian models

(2012) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Nonmotor Manifestations in Parkinson Disease

(2012) Oscar Bernal-Pacheco et al.   NEUROLOGIST

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

(2012) Ying Yang et al.   NEURON

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma

(2012) I. A. Babar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs and neurodegeneration: role and impact

(2012) Masashi Abe et al.   TRENDS IN CELL BIOLOGY

microRNA-34c is a novel target to treat dementias

(2011) Athanasios Zovoilis et al.   EMBO JOURNAL

Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease

(2011) Hui-Ming Gao et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function

(2011) Elena Miñones-Moyano et al.   HUMAN MOLECULAR GENETICS

Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease

(2011) Philip Michael Gaughwin et al.   HUMAN MOLECULAR GENETICS

Identification of blood microRNAs associated to Parkinsońs disease

(2011) Regina Margis et al.   JOURNAL OF BIOTECHNOLOGY

Functions of Noncoding RNAs in Neural Development and Neurological Diseases

(2011) Shan Bian et al.   MOLECULAR NEUROBIOLOGY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions

(2011) Yasuo Miki et al.   NEUROPATHOLOGY

Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy

(2011) Y. Chiba et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

MicroRNA Expression Aberration as Potential Peripheral Blood Biomarkers for Schizophrenia

(2011) Chi-Yu Lai et al.   PLoS One

Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

(2011) Madalena Martins et al.   PLoS One

Optimizing levodopa therapy for Parkinson’s disease with levodopa/carbidopa/entacapone: implications from a clinical and patient perspective

(2011) David Brooks   Neuropsychiatric Disease and Treatment

MicroRNAs and deregulated gene expression networks in neurodegeneration

(2010) Kai-Christian Sonntag   BRAIN RESEARCH

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction

(2010) Yuri D'Alessandra et al.   EUROPEAN HEART JOURNAL

MicroRNA-155 Targets SMAD2 and Modulates the Response of Macrophages to Transforming Growth Factor-β

(2010) Fethi Louafi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

(2010) Epaminondas Doxakis   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

(2010) Stephan Gehrke et al.   NATURE

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: A pathogenetically based approach

(2010) Karin D. van Dijk et al.   NEUROBIOLOGY OF DISEASE

MPTP-Induced Neuroinflammation Increases the Expression of Pro-Inflammatory Cytokines and Their Receptors in Mouse Brain

(2010) Dario Domenico Lofrumento et al.   NEUROIMMUNOMODULATION

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

(2010) Dieter Edbauer et al.   NEURON

FGF20 rs12720208 SNP and microRNA-433 variation: No association with Parkinson's disease in Spanish patients

(2010) Lorena de Mena et al.   NEUROSCIENCE LETTERS

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

Evidence for natural antisense transcript-mediated inhibition of microRNA function

(2010) Mohammad Ali Faghihi et al.   GENOME BIOLOGY

Different timings of dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system

(2009) Yoko Kawase-Koga et al.   DEVELOPMENTAL DYNAMICS

Function of microRNA-375 and microRNA-124a in pancreas and brain

(2009) Nadine N. Baroukh et al.   FEBS Journal

Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair

(2009) Oliver Rothfuss et al.   HUMAN MOLECULAR GENETICS

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

FGF20and Parkinson's disease: No evidence of association or pathogenicity via α-synuclein expression

(2009) Christian Wider et al.   MOVEMENT DISORDERS

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

Revisiting the principles of microRNA target recognition and mode of action

(2009) Peter Brodersen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant adeno-associated virus-mediated microRNA delivery into the postnatal mouse brain reveals a role for miR-134 in dendritogenesis in vivo

(2009) Mette Christensen   Frontiers in Neural Circuits

Variation in the miRNA-433 Binding Site of FGF20 Confers Risk for Parkinson Disease by Overexpression of α-Synuclein

(2008) Gaofeng Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MicroRNAs (miRNAs) in Neurodegenerative Diseases

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

Dicer1 Is Essential for Female Fertility and Normal Development of the Female Reproductive System

(2008) Xiaoman Hong et al.   ENDOCRINOLOGY

MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation

(2008) Jenn-Yah Yu et al.   EXPERIMENTAL CELL RESEARCH

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

(2008) N. Liu et al.   GENES & DEVELOPMENT

The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of  -Site Amyloid Precursor Protein-Cleaving Enzyme 1

(2008) W.-X. Wang et al.   JOURNAL OF NEUROSCIENCE

Assessing fetal nerve cell grafts in Parkinson's disease

(2008) Heiko Braak et al.   NATURE MEDICINE

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

A miRNA Signature of Prion Induced Neurodegeneration

(2008) Reuben Saba et al.   PLoS One

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration

(2008) T. L. Cuellar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY