Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules

Environmental and Occupational Exposures and Amyotrophic Lateral Sclerosis in New England

(2017) Angeline S. Andrew et al.   Neurodegenerative Diseases

Phosphoproteins in extracellular vesicles as candidate markers for breast cancer

(2017) I-Hsuan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guanine glycation repair by DJ-1/Park7 and its bacterial homologs

(2017) Gilbert Richarme et al.   SCIENCE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

(2017) Reddy Ranjith K. Sama et al.   Scientific Reports

Biological Spectrum of Amyotrophic Lateral Sclerosis Prions

(2017) Magdalini Polymenidou et al.   Cold Spring Harbor Perspectives in Medicine

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair

(2017) Svitlana Garbuzova-Davis et al.   Scientific Reports

A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans

(2016) Leah Houri-Ze’evi et al.   CELL

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs

(2016) Eunju Kang et al.   Cell Stem Cell

Size-Dependent Deposition, Translocation, and Microglial Activation of Inhaled Silver Nanoparticles in the Rodent Nose and Brain

(2016) Esther Shin Patchin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington's diseasein vitromodel

(2016) Mijung Lee et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS

(2016) Thomas Taetzsch et al.   JOURNAL OF NEUROSCIENCE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

(2016) Andreea Iren Serban et al.   PLoS One

Genetic Factors Are Not the Major Causes of Chronic Diseases

(2016) Stephen M. Rappaport   PLoS One

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

(2016) Laura Ferraiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutics from Adult Stem Cells and the Hype Curve

(2016) Greg Maguire   ACS Medicinal Chemistry Letters

Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability

(2016) Andrea Magrì et al.   Scientific Reports

Hypoxic conditioned medium from mesenchymal stem cells promotes lymphangiogenesis by regulation of mitochondrial-related proteins

(2016) Chang Youn Lee et al.   Stem Cell Research & Therapy

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72 -ALS/FTD

(2016) Thomas Westergard et al.   Cell Reports

Intergenerational Transfer of Epigenetic Information in Sperm

(2016) Oliver J. Rando   Cold Spring Harbor Perspectives in Medicine

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

(2016) Liangzhong Lim et al.   PLOS BIOLOGY

Skeletal Muscle Remodelling as a Function of Disease Progression in Amyotrophic Lateral Sclerosis

(2016) L. Jensen et al.   Biomed Research International

Evaluation of the Microbial Diversity in Amyotrophic Lateral Sclerosis Using High-Throughput Sequencing

(2016) Xin Fang et al.   Frontiers in Microbiology

Association of Environmental Toxins With Amyotrophic Lateral Sclerosis

(2016) Feng-Chiao Su et al.   JAMA Neurology

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

(2016) Panayiota Petrou et al.   JAMA Neurology

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase

(2016) Maria-Letizia Campanari et al.   Frontiers in Molecular Neuroscience

Chemotherapy and Stem Cell Transplantation Increase p16 INK4a Expression, a Biomarker of T-cell Aging

(2016) William A. Wood et al.   EBioMedicine

VGF Protein and Its C-Terminal Derived Peptides in Amyotrophic Lateral Sclerosis: Human and Animal Model Studies

(2016) Carla Brancia et al.   PLoS One

Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

(2016) Shu G. Chen et al.   Scientific Reports

C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

(2015) Max Koppers et al.   ANNALS OF NEUROLOGY

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

(2015) Reiko Horai et al.   IMMUNITY

A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast

(2015) Søs G. Mathiassen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept

(2015) Maria A. Gubbiotti et al.   MATRIX BIOLOGY

Combination therapies: The next logical Step for the treatment of synucleinopathies?

(2015) Elvira Valera et al.   MOVEMENT DISORDERS

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

Primary fibroblasts cultures reveal TDP-43 abnormalities in amyotrophic lateral sclerosis patients with and without SOD1 mutations

(2015) Mario Sabatelli et al.   NEUROBIOLOGY OF AGING

Potential Environmental Factors in Amyotrophic Lateral Sclerosis

(2015) Björn Oskarsson et al.   NEUROLOGIC CLINICS

Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

(2015) Toshihide Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad

(2015) Anjoscha Kaus et al.   Frontiers in Cellular Neuroscience

Mitochondrial dynamism and the pathogenesis of Amyotrophic Lateral Sclerosis

(2015) Mauro Cozzolino et al.   Frontiers in Cellular Neuroscience

Receptor for Advanced Glycation End Products and its Inflammatory Ligands are Upregulated in Amyotrophic Lateral Sclerosis

(2015) Judyta K. Juranek et al.   Frontiers in Cellular Neuroscience

Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?

(2015) Shynrye Lee et al.   Experimental Neurobiology

Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding

(2015) Leslie I Grad et al.   Prion

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans

(2014) Oded Rechavi et al.   CELL

Extracellular matrix regulation of inflammation in the healthy and injured spinal cord

(2014) Andrew D. Gaudet et al.   EXPERIMENTAL NEUROLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Injection of a Soluble Fragment of Neural Agrin (NT-1654) Considerably Improves the Muscle Pathology Caused by the Disassembly of the Neuromuscular Junction

(2014) Stefan Hettwer et al.   PLoS One

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

(2014) Eleonora Distrutti et al.   PLoS One

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

(2014) Haiqun Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

(2014) E. A. Winkler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrathecal Delivery of Mesenchymal Stromal Cells Protects the Structure of Altered Perineuronal Nets in SOD1 Rats and Amends the Course of ALS

(2014) Serhiy Forostyak et al.   STEM CELLS

Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: Involvement of glutamate excitotoxicity

(2014) Daiane Cattani et al.   TOXICOLOGY

Detection of cyanobacterial neurotoxin β-N-methylamino-l-alanine within shellfish in the diet of an ALS patient in Florida

(2014) Sandra Anne Banack et al.   TOXICON

Skeletal Muscle Satellite Cells in Amyotrophic Lateral Sclerosis

(2014) Annarita Scaramozza et al.   ULTRASTRUCTURAL PATHOLOGY

Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1G93A Amyotrophic Lateral Sclerosis mouse model

(2014) Jessica R. Maximino et al.   Frontiers in Cellular Neuroscience

Blood-CNS Barrier Impairment in ALS patients versus an animal model

(2014) Svitlana Garbuzova-Davis et al.   Frontiers in Cellular Neuroscience

The role of miRNA in motor neuron disease

(2014) Min Jeong Kye et al.   Frontiers in Cellular Neuroscience

Systems Biology Approach to Developing “Systems Therapeutics”

(2014) Greg Maguire   ACS Medicinal Chemistry Letters

Searching for a link between the L-BMAA neurotoxin and amyotrophic lateral sclerosis: a study protocol of the French BMAALS programme

(2014) A. Delzor et al.   BMJ Open

Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion

(2013) Zhengrui Xi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

(2013) Johannes Brettschneider et al.   ANNALS OF NEUROLOGY

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

(2013) Thomas Philips et al.   BRAIN

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

A systematic review of cancer GWAS and candidate gene meta-analyses reveals limited overlap but similar effect sizes

(2013) Christine Q Chang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse

(2013) Urmi Bandyopadhyay et al.   PLoS One

Graft failure in the modern era of allogeneic hematopoietic SCT

(2012) R Olsson et al.   BONE MARROW TRANSPLANTATION

Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Enhances Engraftment and Angiogenesis of Mesenchymal Stem Cells in Diabetic Hindlimb Ischemia

(2012) Debin Lu et al.   DIABETES

Podosomes in migrating microglia: components and matrix degradation

(2012) Catherine Vincent et al.   Journal of Neuroinflammation

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Eccentric Exercise Facilitates Mesenchymal Stem Cell Appearance in Skeletal Muscle

(2012) M. Carmen Valero et al.   PLoS One

Abnormalities of satellite cells function in amyotrophic lateral sclerosis

(2011) Pierre-François Pradat et al.   Amyotrophic Lateral Sclerosis

Mesenchymal Stromal Cells: A New Tool against Graft-versus-Host Disease?

(2011) Frédéric Baron et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The critical role of agrin in the hematopoietic stem cell niche

(2011) C. Mazzon et al.   BLOOD

S100B Protein Stimulates Microglia Migration via RAGE-dependent Up-regulation of Chemokine Expression and Release

(2011) Roberta Bianchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

(2011) P. Diaz-Amarilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adductomics: Characterizing exposures to reactive electrophiles

(2011) Stephen M. Rappaport et al.   TOXICOLOGY LETTERS

SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis

(2010) A. Orlacchio et al.   BRAIN

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Environment and Disease Risks

(2010) S. M. Rappaport et al.   SCIENCE

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation

(2008) Chiara Chiellini et al.   BMC MOLECULAR BIOLOGY

Proteolytic fragments of laminin promote excitotoxic neurodegeneration by up-regulation of the KA1 subunit of the kainate receptor

(2008) Zu-Lin Chen et al.   JOURNAL OF CELL BIOLOGY

Accumulation of chondroitin sulfate proteoglycans in the microenvironment of spinal motor neurons in amyotrophic lateral sclerosis transgenic rats

(2008) Hideki Mizuno et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Protein Damage by Reactive Electrophiles: Targets and Consequences

(2007) Daniel C. Liebler   CHEMICAL RESEARCH IN TOXICOLOGY