Exosome-mediated amplification of endogenous brain repair mechanisms and brain and systemic organ interaction in modulating neurological outcome after stroke

Plasma Exosomal miR-422a and miR-125b-2-3p Serve as Biomarkers for Ischemic Stroke

(2018) Dong-Bin Li et al.   CURRENT NEUROVASCULAR RESEARCH

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

(2018) Jing Jing Li et al.   Journal of Neuroinflammation

Cell-based and pharmacological neurorestorative therapies for ischemic stroke

(2018) Poornima Venkat et al.   NEUROPHARMACOLOGY

Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents

(2017) Verena Börger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage

(2017) Laura Otero-Ortega et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of exosomes in CNS inflammation and their involvement in multiple sclerosis

(2017) Igor Selmaj et al.   JOURNAL OF NEUROIMMUNOLOGY

Ischemic stroke damages the intestinal mucosa and induces alteration of the intestinal lymphocytes and CCL19 mRNA in rats

(2017) Yaning Liu et al.   NEUROSCIENCE LETTERS

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Concise Review: MSC-Derived Exosomes for Cell-Free Therapy

(2017) Donald G. Phinney et al.   STEM CELLS

Multipotent Adult Progenitor Cells Enhance Recovery After Stroke by Modulating the Immune Response from the Spleen

(2017) Bing Yang et al.   STEM CELLS

Challenge and Yield of Enrolling Racially and Ethnically Diverse Patient Populations in Low Event Rate Clinical Trials

(2017) Alice J. Sheffet et al.   STROKE

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke

(2017) Laura Otero-Ortega et al.   Scientific Reports

MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis

(2017) Romain Madelaine et al.   Cell Reports

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Mediators of Anti-Inflammatory Effects: Endorsement of Macrophage Polarization

(2017) Claudia Lo Sicco et al.   Stem Cells Translational Medicine

MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke

(2017) Jieli Chen et al.   Translational Stroke Research

Blood–Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke

(2017) Poornima Venkat et al.   Journal of the American Heart Association

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies

(2017) Francisca Alcayaga-Miranda et al.   Frontiers in Immunology

Post-stroke pneumonia at the stroke unit – a registry based analysis of contributing and protective factors

(2016) Karl Matz et al.   BMC Neurology

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Stroke and cardiac cell death: Two peas in a pod

(2016) Chiara Gonzales-Portillo et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain

(2016) Poornima Venkat et al.   CROATIAN MEDICAL JOURNAL

Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus‐derived extracellular vesicles

(2016) Sriram Balusu et al.   EMBO Molecular Medicine

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons

(2016) Yi Zhang et al.   MOLECULAR NEUROBIOLOGY

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Neurorestorative Responses to Delayed Human Mesenchymal Stromal Cells Treatment of Stroke in Type 2 Diabetic Rats

(2016) Tao Yan et al.   STROKE

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

(2016) Katarzyna Winek et al.   STROKE

Correcting the Trajectory of Stroke Therapeutic Research

(2016) Keith R. Pennypacker et al.   Translational Stroke Research

Translational Hurdles in Stroke Recovery Studies

(2016) Jukka Jolkkonen et al.   Translational Stroke Research

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche

(2016) Alejandro Luarte et al.   Stem Cells International

MSCs-Derived Exosomes: Cell-Secreted Nanovesicles with Regenerative Potential

(2016) Ana Marote et al.   Frontiers in Pharmacology

Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients

(2016) Qiuhong Ji et al.   PLoS One

Low estimated glomerular filtration rate is associated with poor outcomes in patients who suffered a large artery atherosclerosis stroke

(2015) Shin-Joe Yeh et al.   ATHEROSCLEROSIS

Pathologic function and therapeutic potential of exosomes in cardiovascular disease

(2015) Shaina Ailawadi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Emerging potential of exosomes and noncoding microRNAs for the treatment of neurological injury/diseases

(2015) Michael Chopp et al.   EXPERT OPINION ON EMERGING DRUGS

MicroRNAs Regulate Mitochondrial Function in Cerebral Ischemia-Reperfusion Injury

(2015) Yue Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis

(2015) Yuji Nagatomo et al.   JOURNAL OF CARDIAC FAILURE

Exosome-mediated inflammasome signaling after central nervous system injury

(2015) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF NEUROCHEMISTRY

Bacterial Translocation and Plasma Cytokines During Transcatheter and Open-Heart Aortic Valve Implantation

(2015) Christophe Adrie et al.   SHOCK

2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment

(2015) William J. Powers et al.   STROKE

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke

(2015) Sandra A. Acosta et al.   STROKE

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

(2015) John R. Kelly et al.   Frontiers in Cellular Neuroscience

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Neurorestorative Therapy for Stroke

(2014) Jieli Chen et al.   Frontiers in Human Neuroscience

Exosomes as mediators of neuroinflammation

(2014) Archana Gupta et al.   Journal of Neuroinflammation

Stroke Increases Neural Stem Cells and Angiogenesis in the Neurogenic Niche of the Adult Mouse

(2014) Rui Lan Zhang et al.   PLoS One

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

Comparison of Associations of Outcomes After Stroke With Estimated GFR Using Chinese Modifications of the MDRD Study and CKD-EPI Creatinine Equations: Results From the China National Stroke Registry

(2013) Xianwei Wang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans

(2013) Guangwen Long et al.   BMC Neurology

Intravenous Administration of Human Umbilical Tissue-Derived Cells Improves Neurological Function in Aged Rats after Embolic Stroke

(2013) Li Zhang et al.   CELL TRANSPLANTATION

The Emerging Role of microRNA in Stroke

(2013) Georgios Koutsis et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients

(2013) Liu Qiang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Cell based therapies for ischemic stroke: From basic science to bedside

(2013) Xinfeng Liu et al.   PROGRESS IN NEUROBIOLOGY

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

Ischemic Stroke Brain Sends Indirect Cell Death Signals to the Heart

(2013) Hiroto Ishikawa et al.   STROKE

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke

(2013) María Gutiérrez-Fernández et al.   Stem Cell Research & Therapy

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

(2012) Ronne Wee Yeh Yeo et al.   ADVANCED DRUG DELIVERY REVIEWS

Relationship between kidney damage and stroke types in Japanese patients

(2012) Kosuke Kudo et al.   Clinical and Experimental Nephrology

Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation

(2012) Benjamin Buller et al.   GLIA

Characteristics and early and long-term outcome in patients with acute ischemic stroke and low ejection fraction

(2012) Haralampos Milionis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Neuroprotection for Stroke: Current Status and Future Perspectives

(2012) Jens Minnerup et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiovascular and neurological causes of sudden death after ischaemic stroke

(2012) Peter Sörös et al.   LANCET NEUROLOGY

Microbes and the gut-brain axis

(2012) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Proteinuria and clinical outcomes after ischemic stroke

(2012) Y. Kumai et al.   NEUROLOGY

Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro

(2012) Kazuhide Hayakawa et al.   NEUROSCIENCE LETTERS

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

(2012) Hongqi Xin et al.   STEM CELLS

Axonal Outgrowth and Dendritic Plasticity in the Cortical Peri-Infarct Area After Experimental Stroke

(2012) Yuji Ueno et al.   STROKE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Microglial microvesicle secretion and intercellular signaling

(2012) Elena Turola   Frontiers in Physiology

Changes in Serum Ghrelin and Small Intestinal Motility in Rats with Ischemic Stroke

(2011) Xinping Xu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Post-stroke infection: A systematic review and meta-analysis

(2011) Willeke F Westendorp et al.   BMC Neurology

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

(2011) Arthur Liesz et al.   BRAIN

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

(2011) S. Gatti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis

(2010) Shirley H. J. Mei et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone Marrow Stromal Cells Enhance Inter- and Intracortical Axonal Connections after Ischemic Stroke in Adult Rats

(2010) Zhongwu Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antibacterial Effect of Human Mesenchymal Stem Cells Is Mediated in Part from Secretion of the Antimicrobial Peptide LL-37

(2010) Anna Krasnodembskaya et al.   STEM CELLS

Long-Term Prognosis of Acute Kidney Injury after First Acute Stroke

(2009) G. Tsagalis et al.   Clinical Journal of the American Society of Nephrology

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

Patterns and Dynamics of Subventricular Zone Neuroblast Migration in the Ischemic Striatum of the Adult Mouse

(2009) Rui L Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inosine Alters Gene Expression and Axonal Projections in Neurons Contralateral to a Cortical Infarct and Improves Skilled Use of the Impaired Limb

(2009) L. Zai et al.   JOURNAL OF NEUROSCIENCE

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

(2009) Zheng Gang Zhang et al.   LANCET NEUROLOGY

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Leukocyte Recruitment and Ischemic Brain Injury

(2009) Gokhan Yilmaz et al.   NEUROMOLECULAR MEDICINE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Takotsubo cardiomyopathy in acute ischemic stroke

(2008) Sohei Yoshimura et al.   ANNALS OF NEUROLOGY

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

Magnetic Resonance Imaging Investigation of Axonal Remodeling and Angiogenesis after Embolic Stroke in Sildenafil-Treated Rats

(2008) Guangliang Ding et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The spleen contributes to stroke‐induced neurodegeneration

(2008) Craig T. Ajmo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contralesional Axonal Remodeling of the Corticospinal System in Adult Rats After Stroke and Bone Marrow Stromal Cell Treatment

(2008) Zhongwu Liu et al.   STROKE

The impact of acute kidney injury on short-term survival in an Eastern European population with stroke

(2007) A. Covic et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION