Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease

(2016) Anne B. Rocher et al.   NEUROBIOLOGY OF DISEASE

The role of tau in the pathological process and clinical expression of Huntington’s disease

(2015) Romina Vuono et al.   BRAIN

Huntington Disease

(2015) Praveen Dayalu et al.   NEUROLOGIC CLINICS

Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases

(2015) Bradley M. Coleman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease

(2015) B Khalil et al.   Cell Death & Disease

Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain

(2015) Margaret M. P. Pearce et al.   Nature Communications

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

(2015) Maddalena Costanzo et al.   BIOCHEMICAL JOURNAL

Exosomes in Neurologic and Psychiatric Disorders

(2014) Irene Tsilioni et al.   CLINICAL THERAPEUTICS

Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease

(2014) Marja D. Sepers et al.   DRUG DISCOVERY TODAY

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

(2014) David Blum et al.   HUMAN MOLECULAR GENETICS

Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease

(2014) Maud Gratuze et al.   HUMAN MOLECULAR GENETICS

A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

(2014) Cendrine Tourette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glial Wingless/Wnt Regulates Glutamate Receptor Clustering and Synaptic Physiology at the Drosophila Neuromuscular Junction

(2014) K. S. Kerr et al.   JOURNAL OF NEUROSCIENCE

Emerging Roles of Extracellular Vesicles in the Nervous System

(2014) L. Rajendran et al.   JOURNAL OF NEUROSCIENCE

Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

(2014) Davide Chiasserini et al.   Journal of Proteomics

Huntingtin is associated with cytomatrix proteins at the presynaptic terminal

(2014) Jia Yao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

MicroRNAs in Neuronal Communication

(2014) Guilherme Shigueto Vilar Higa et al.   MOLECULAR NEUROBIOLOGY

Targets for future clinical trials in Huntington's disease: What's in the pipeline?

(2014) Edward J. Wild et al.   MOVEMENT DISORDERS

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

(2014) Eline Pecho-Vrieseling et al.   NATURE NEUROSCIENCE

eulerAPE: Drawing Area-Proportional 3-Venn Diagrams Using Ellipses

(2014) Luana Micallef et al.   PLoS One

Integrated regulation of motor-driven organelle transport by scaffolding proteins

(2014) Meng-meng Fu et al.   TRENDS IN CELL BIOLOGY

microRNA-128a dysregulation in transgenic Huntington’s disease monkeys

(2014) Jannet Kocerha et al.   Molecular Brain

Exosomes as a novel way of interneuronal communication

(2013) Mathilde Chivet et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Synaptic control of local translation: the plot thickens with new characters

(2013) María Gabriela Thomas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease

(2013) Muhammad U. Sajjad et al.   HUMAN MOLECULAR GENETICS

LRRK2 secretion in exosomes is regulated by 14-3-3

(2013) K. B. Fraser et al.   HUMAN MOLECULAR GENETICS

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

(2013) M. Costanzo et al.   JOURNAL OF CELL SCIENCE

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

TNF-  Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors

(2013) H. Pribiag et al.   JOURNAL OF NEUROSCIENCE

Opposing Action of Nuclear Factor  B and Polo-like Kinases Determines a Homeostatic End Point for Excitatory Synaptic Adaptation

(2013) A. B. Mihalas et al.   JOURNAL OF NEUROSCIENCE

Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites

(2013) G. Liot et al.   JOURNAL OF NEUROSCIENCE

Exosomes: Mediators of Neurodegeneration, Neuroprotection and Therapeutics

(2013) Anuradha Kalani et al.   MOLECULAR NEUROBIOLOGY

Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance

(2013) Boxun Lu et al.   NATURE NEUROSCIENCE

Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

(2013) Ceren Korkut et al.   NEURON

Homeostatic Signaling and the Stabilization of Neural Function

(2013) Graeme W. Davis   NEURON

Tuning into diversity of homeostatic synaptic plasticity

(2013) Kevin F.H. Lee et al.   NEUROPHARMACOLOGY

Molecular mechanisms of homeostatic synaptic downscaling

(2013) Benjamin Siddoway et al.   NEUROPHARMACOLOGY

Neuroimmune regulation of homeostatic synaptic plasticity

(2013) Horia Pribiag et al.   NEUROPHARMACOLOGY

Homeostatic plasticity at the Drosophila neuromuscular junction

(2013) C. Andrew Frank   NEUROPHARMACOLOGY

Huntingtin’s Function in Axonal Transport Is Conserved in Drosophila melanogaster

(2013) Diana Zala et al.   PLoS One

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington’s Disease-Related Mechanisms

(2013) Ana Jovicic et al.   PLoS One

Characterization of Human Thymic Exosomes

(2013) Gabriel Skogberg et al.   PLoS One

Neuronal Ca2+dyshomeostasis in Huntington disease

(2013) Marta Giacomello et al.   Prion

Modulation of B-cell exosome proteins by gamma herpesvirus infection

(2013) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanisms driving homeostatic plasticity of neurotransmitter release

(2013) Vesna Lazarevic et al.   Frontiers in Cellular Neuroscience

Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

(2013) Kyongman An et al.   Molecular Brain

Multiple Aspects of Gene Dysregulation in Huntington’s Disease

(2013) Lara Moumné et al.   Frontiers in Neurology

Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington’s disease mice

(2012) Xueyi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

(2012) Saumya Pant et al.   BIOCHEMICAL PHARMACOLOGY

Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database

(2012) Ravi Kiran Reddy Kalathur et al.   BMC Neurology

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

(2012) Anja Schneider et al.   CELL AND TISSUE RESEARCH

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis

(2012) Tamara Ratovitski et al.   CELL CYCLE

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

(2012) Kate Koles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis

(2012) Brady P. Culver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-regulation of GLT1 reverses the deficit in cortically evoked striatal ascorbate efflux in the R6/2 mouse model of Huntington’s disease

(2012) Benjamin R. Miller et al.   JOURNAL OF NEUROCHEMISTRY

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Synaptic retinoic acid signaling and homeostatic synaptic plasticity

(2012) Lu Chen et al.   NEUROPHARMACOLOGY

Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntingtons Disease

(2011) R. Vidal et al.   CURRENT MOLECULAR MEDICINE

α-Synuclein levels modulate Huntington's disease in mice

(2011) Silvia Corrochano et al.   HUMAN MOLECULAR GENETICS

Impaired α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin

(2011) Madhuchhanda Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Synapse to Nucleus and Back Again--Communication over Distance within Neurons

(2011) M. Fainzilber et al.   JOURNAL OF NEUROSCIENCE

Modification of Mecp2 dosage alters axonal transport through the Huntingtin/Hap1 pathway

(2011) Jean-Christophe Roux et al.   NEUROBIOLOGY OF DISEASE

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

(2011) L.A. Raymond et al.   NEUROSCIENCE

Allostasis: A model of predictive regulation

(2011) Peter Sterling   PHYSIOLOGY & BEHAVIOR

Proteomic analysis of urine exosomes by multidimensional protein identification technology (MudPIT)

(2011) Zhen Wang et al.   PROTEOMICS

Micro RNA -214,-150,-146a and-125b targetHuntingtingene

(2011) Mithun Sinha et al.   RNA Biology

Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function

(2011) G. Turrigiano   Cold Spring Harbor Perspectives in Biology

Altered microRNA regulation in Huntington's disease models

(2010) Soon-Tae Lee et al.   EXPERIMENTAL NEUROLOGY

Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

(2010) Kun Huang et al.   NEUROBIOLOGY OF DISEASE

A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing

(2010) Eulàlia Martí et al.   NUCLEIC ACIDS RESEARCH

CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches

(2009) Douglas R. Langbehn et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

(2009) Bok Hong et al.   BMC GENOMICS

Effects of partial suppression of parkin on huntingtin mutant R6/1 mice

(2009) Isabel Rubio et al.   BRAIN RESEARCH

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

(2009) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

(2009) Ashwani K Thakur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systems approach to explore components and interactions in the presynapse

(2009) Noura S. Abul-Husn et al.   PROTEOMICS

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Huntington's disease: from pathology and genetics to potential therapies

(2008) Sara Imarisio et al.   BIOCHEMICAL JOURNAL

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

(2008) Diana Zala et al.   HUMAN MOLECULAR GENETICS

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling

(2008) Bulent Ataman et al.   NEURON

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE