The ion selectivity filter is not an activation gate in TRPV1-3 channels

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

(2019) Feng Zhang et al.   eLife

A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

(2019) Marcus Schewe et al.   SCIENCE

A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation

(2019) Fayal Abderemane-Ali et al.   NEURON

Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes

(2019) Lejla Zubcevic et al.   eLife

Regulatory switch at the cytoplasmic interface controls TRPV channel gating

(2019) Lejla Zubcevic et al.   eLife

Identification and characterization of hydrophobic gate residues in TRP channels

(2018) Wang Zheng et al.   FASEB JOURNAL

Conformational plasticity in the selectivity filter of the TRPV2 ion channel

(2018) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy

(2018) M. Gregor Madej et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

(2018) Qiang Su et al.   Nature Communications

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

(2018) Wang Zheng et al.   Nature Communications

Conformational plasticity in the selectivity filter of the TRPV2 ion channel

(2018) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium

(2018) Yihe Huang et al.   NATURE

Structure and gating mechanism of the transient receptor potential channel TRPV3

(2018) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Different agonists induce distinct single-channel conductance states in TRPV1 channels

(2018) Jesús Aldair Canul-Sánchez et al.   JOURNAL OF GENERAL PHYSIOLOGY

A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine

(2018) Marina A. Kasimova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structures of TRPV2 in distinct conformations provide insight into role of the pore turret

(2018) Timothy L. Dosey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Organellar TRP channels

(2018) Xiaoli Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRPV1 pore turret dictates distinct DkTx and capsaicin gating

(2018) Matan Geron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures and gating mechanism of human TRPM2

(2018) Longfei Wang et al.   SCIENCE

Conformational ensemble of the human TRPV3 ion channel

(2018) Lejla Zubcevic et al.   Nature Communications

Structural insights on TRPV5 gating by endogenous modulators

(2018) Taylor E. T. Hughes et al.   Nature Communications

Requirement of extracellular Ca2+ binding to specific amino acids for heat-evoked activation of TRPA1

(2017) Erkin Kurganov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

(2017) Marscha Hirschi et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

The chemical basis for electrical signaling

(2017) William A Catterall et al.   Nature Chemical Biology

Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel

(2017) Victor Pau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heat activation is intrinsic to the pore domain of TRPV1

(2017) Feng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel

(2017) Victor Pau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Pain and Itch by TRP Channels

(2017) Carlene Moore et al.   Neuroscience Bulletin

Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

(2017) Ximena Steinberg et al.   eLife

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rational design and validation of a vanilloid-sensitive TRPV2 ion channel

(2016) Fan Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

(2016) Kevin Oelstrom et al.   Nature Communications

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Selective potentiation of 2-APB-induced activation of TRPV1–3 channels by acid

(2016) Luna Gao et al.   Scientific Reports

Engineering vanilloid-sensitivity into the rat TRPV2 channel

(2016) Feng Zhang et al.   eLife

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

(2016) Chanhyung Bae et al.   eLife

An external sodium ion binding site controls allosteric gating in TRPV1 channels

(2016) Andres Jara-Oseguera et al.   eLife

Role of the Outer Pore Domain in Transient Receptor Potential Vanilloid 1 Dynamic Permeability to Large Cations

(2015) Clare H. Munns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proton block of proton-activated TRPV1 current

(2015) Bo Hyun Lee et al.   JOURNAL OF GENERAL PHYSIOLOGY

Comparative sequence analysis suggests a conserved gating mechanism for TRP channels

(2015) Eugene Palovcak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

(2015) Fan Yang et al.   Nature Chemical Biology

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

(2015) Mufeng Li et al.   NATURE NEUROSCIENCE

Measurement of relative Ca2+ permeability during sustained activation of TRPV1 receptors

(2015) Damien S. K. Samways et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

(2015) Shilong Yang et al.   Nature Communications

Evolutionarily conserved intracellular gate of voltage-dependent sodium channels

(2014) Kevin Oelstrom et al.   Nature Communications

Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold

(2013) Xu Cao et al.   JOURNAL OF GENERAL PHYSIOLOGY

C-type inactivation of voltage-gated K+channels: Pore constriction or dilation?

(2013) Toshinori Hoshi et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Residues in the pore region ofDrosophilatransient receptor potential A1 dictate sensitivity to thermal stimuli

(2012) Hong Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

(2012) B. Toth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pore structure and gating mechanism of K2P channels

(2011) Paula L Piechotta et al.   EMBO JOURNAL

Multiple modalities converge on a common gate to control K2Pchannel function

(2011) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region

(2011) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage Profile along the Permeation Pathway of an Open Channel

(2010) Jorge E. Contreras et al.   BIOPHYSICAL JOURNAL

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

(2010) Christopher J. Bohlen et al.   CELL

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

Fr-TM-align: a new protein structural alignment method based on fragment alignments and the TM-score

(2009) Shashi Pandit et al.   BMC BIOINFORMATICS

Proton inhibition of unitary currents of vanilloid receptors

(2009) Beiying Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure–functional intimacies of transient receptor potential channels

(2009) Ramon Latorre et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Properties of the Inner Pore Region of TRPV1 Channels Revealed by Block with Quaternary Ammoniums

(2008) Andrés Jara-Oseguera et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gating the pore of P2X receptor channels

(2008) Mufeng Li et al.   NATURE NEUROSCIENCE

Pore region of TRPV3 ion channel is specifically required for heat activation

(2008) Jörg Grandl et al.   NATURE NEUROSCIENCE

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic

(2008) Héctor Salazar et al.   NATURE NEUROSCIENCE

A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating

(2008) Benjamin R. Myers et al.   NEURON

Gating at the selectivity filter in cyclic nucleotide-gated channels

(2008) J. E. Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA