Structure and gating mechanism of the transient receptor potential channel TRPV3

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

(2018) Appu K. Singh et al.   Nature Communications

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Ca 2+ -Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases

(2017) Gongxin Wang et al.   MOLECULAR PHARMACOLOGY

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Overexpression of TRPV3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer

(2016) Xiaolei Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia

(2015) Reona Aijima et al.   FASEB JOURNAL

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Ultrastable gold substrates for electron cryomicroscopy

(2014) C. J. Russo et al.   SCIENCE

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

(2013) Anna Garcia-Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for channel function

(2013) Di-Jing Shi et al.   Protein & Cell

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome

(2012) Zhimiao Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

2-Aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism

(2012) Rikki Chokshi et al.   Channels

Advances in modulating thermosensory TRP channels

(2012) Antonio Ferrer-Montiel et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes

(2012) Jialie Luo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Analgesic Potential of TRPV3 Antagonists

(2011) Regina M. Reilly et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2hydrolysis

(2011) Julia F. Doerner et al.   JOURNAL OF GENERAL PHYSIOLOGY

Hysteresis of gating underlines sensitization of TRPV3 channels

(2011) Beiying Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation

(2010) Xiping Cheng et al.   CELL

Ca2+-Dependent Desensitization of TRPV2 Channels Is Mediated by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate

(2010) J. Mercado et al.   JOURNAL OF NEUROSCIENCE

Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4

(2009) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

(2008) K Togashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate Mediates Calcium-induced Inactivation of TRPV6 Channels

(2008) Baskaran Thyagarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations

(2008) Rui Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pore region of TRPV3 ion channel is specifically required for heat activation

(2008) Jörg Grandl et al.   NATURE NEUROSCIENCE

Monoterpenoid agonists of TRPV3

(2007) A K Vogt-Eisele et al.   BRITISH JOURNAL OF PHARMACOLOGY