Dawning of a new era in TRP channel structural biology by cryo-electron microscopy

Cryo-electron microscopy for structural analysis of dynamic biological macromolecules

(2018) Kazuyoshi Murata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Polycystin and calcium signaling in cell death and survival

(2018) Fernanda O. Lemos et al.   CELL CALCIUM

Effects of radiation damage in studies of protein-DNA complexes by cryo-EM

(2017) M. Mishyna et al.   MICRON

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

(2017) Marscha Hirschi et al.   NATURE

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

(2017) Qingfeng Chen et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

Advances in the field of single-particle cryo-electron microscopy over the last decade

(2017) Joachim Frank   Nature Protocols

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel

(2017) Minghui Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

(2017) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel

(2017) Minghui Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine

(2017) Sebastian M Fica et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism

(2017) Sensen Zhang et al.   Protein & Cell

TRPs in Pain Sensation

(2017) Isaac Jardín et al.   Frontiers in Physiology

Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels

(2017) Fredrik Elinder et al.   Frontiers in Physiology

Trends in the Electron Microscopy Data Bank (EMDB)

(2017) Ardan Patwardhan   Acta Crystallographica Section D-Structural Biology

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

(2017) Appu K. Singh et al.   Scientific Reports

Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels

(2016) Ignacio Diaz-Franulic et al.   Annual Review of Biophysics

A Reminiscence about Early Times of Vitreous Water in Electron Cryomicroscopy

(2016) Jacques Dubochet   BIOPHYSICAL JOURNAL

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

Competitive inhibition of TRPV1-calmodulin interaction by vanilloids

(2016) Anasztázia Hetényi et al.   FEBS LETTERS

Role of Oxidized Lipids and TRP Channels in Orofacial Pain and Inflammation

(2016) K.M. Hargreaves et al.   JOURNAL OF DENTAL RESEARCH

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanodiscs for structural and functional studies of membrane proteins

(2016) Ilia G Denisov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The impact of recent improvements in cryo-electron microscopy technology on the understanding of bacterial ribosome assembly

(2016) Aida Razi et al.   NUCLEIC ACIDS RESEARCH

While the revolution will not be crystallized, biochemistry reigns supreme

(2016) Yoshimasa Takizawa et al.   PROTEIN SCIENCE

How cryo-electron microscopy and X-ray crystallography complement each other

(2016) Hong-Wei Wang et al.   PROTEIN SCIENCE

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanodiscs for structural and functional studies of membrane proteins

(2016) Ilia G Denisov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease

(2016) Luis F. Menezes et al.   EBioMedicine

Cryo-electron Microscopy Analysis of Structurally Heterogeneous Macromolecular Complexes

(2016) Slavica Jonić   Computational and Structural Biotechnology Journal

Overview and future of single particle electron cryomicroscopy

(2015) Richard Henderson   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Primer to Single-Particle Cryo-Electron Microscopy

(2015) Yifan Cheng et al.   CELL

Single-Particle Cryo-EM at Crystallographic Resolution

(2015) Yifan Cheng   CELL

The role of TRPMLs in endolysosomal trafficking and function

(2015) Kartik Venkatachalam et al.   CELL CALCIUM

Validating maps from single particle electron cryomicroscopy

(2015) Peter B Rosenthal et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Alignment of cryo-EM movies of individual particles by optimization of image translations

(2015) John L. Rubinstein et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Principles of cryo-EM single-particle image processing

(2015) Fred J. Sigworth   Microscopy

Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy

(2015) Holger Stark et al.   Microscopy

Single-particle cryo-EM data acquisition by using direct electron detection camera

(2015) Shenping Wu et al.   Microscopy

Generalized single-particle cryo-EM – a historical perspective

(2015) Joachim Frank   Microscopy

Single particle electron cryo-microscopy of a mammalian ion channel

(2014) Maofu Liao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Application of Amphipols for Structure–Functional Analysis of TRP Channels

(2014) Kevin W. Huynh et al.   JOURNAL OF MEMBRANE BIOLOGY

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Structural Insight into the Assembly of TRPV Channels

(2014) Kevin W. Huynh et al.   STRUCTURE

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Distinct properties of Ca2+–calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

(2012) Sze-Yi Lau et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy

(2011) Teresa L. Cvetkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The history of TRP channels, a commentary and reflection

(2011) Craig Montell   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular Advances in Autosomal Dominant Polycystic Kidney Disease

(2010) Anna Rachel Gallagher et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Definition and Estimation of Resolution in Single-Particle Reconstructions

(2010) Hstau Y. Liao et al.   STRUCTURE

A novel approximation method of CTF amplitude correction for 3D single particle reconstruction

(2010) Linhua Jiang et al.   ULTRAMICROSCOPY

Hot on the Trail of TRP Channel Structure

(2009) Vera Y. Moiseenkova-Bell et al.   JOURNAL OF GENERAL PHYSIOLOGY

Divide and Conquer: High Resolution Structural Information on TRP Channel Fragments

(2009) Rachelle Gaudet   JOURNAL OF GENERAL PHYSIOLOGY

Structure of TRPV1 channel revealed by electron cryomicroscopy

(2008) V. Y. Moiseenkova-Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA