A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels

Medicinal Chemistry of Potassium Channel Modulators: An update of Recent Progress (2011-2017)

(2018) Vivek K. Vyas et al.   CURRENT MEDICINAL CHEMISTRY

Direct knock-on of desolvated ions governs strict ion selectivity in K+ channels

(2018) Wojciech Kopec et al.   Nature Chemistry

Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels

(2018) Lianne Pope et al.   ACS Chemical Neuroscience

First universal pharmacophore model for hERG1 K + channel activators: acthER

(2017) Serdar Durdagi et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site

(2017) Marco Lolicato et al.   NATURE

Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel

(2017) Victor Pau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Asymmetric mechanosensitivity in a eukaryotic ion channel

(2017) Michael V. Clausen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a Structural View of Drug Binding to hERG K + Channels

(2017) Jamie I. Vandenberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crystal structure of an inactivated mutant mammalian voltage-gated K+ channel

(2017) Victor Pau et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

(2016) Marcus Schewe et al.   CELL

Structural basis for gating the high-conductance Ca2+-activated K+ channel

(2016) Richard K. Hite et al.   NATURE

Intersubunit Concerted Cooperative and cis-Type Mechanisms Modulate Allosteric Gating in Two-Pore-Domain Potassium Channel TREK-2

(2016) Ren-Gong Zhuo et al.   Frontiers in Cellular Neuroscience

Molecular Aspects of Structure, Gating, and Physiology of pH-Sensitive Background K2P and Kir K+-Transport Channels

(2015) Francisco V. Sepúlveda et al.   PHYSIOLOGICAL REVIEWS

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

BK channels: multiple sensors, one activation gate

(2015) Huanghe Yang et al.   Frontiers in Physiology

Structures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site

(2014) Michael J. Lenaeus et al.   BIOCHEMISTRY

Ion permeation in K+ channels occurs by direct Coulomb knock-on

(2014) D. A. Kopfer et al.   SCIENCE

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

(2013) Sviatoslav N. Bagriantsev et al.   ACS Chemical Biology

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Carboxylic Acid (Bio)Isosteres in Drug Design

(2013) Carlo Ballatore et al.   ChemMedChem

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel

(2013) S. G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inhibitor of volume-regulated anion channels DCPIB activates TREK potassium channels in cultured astrocytes

(2012) L Minieri et al.   BRITISH JOURNAL OF PHARMACOLOGY

State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1

(2012) Markus Rapedius et al.   Channels

Structure-Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+(BK) Channel Modulators: The GoSlo-SR Family

(2012) Subhrangsu Roy et al.   ChemMedChem

Structural correlates of selectivity and inactivation in potassium channels

(2011) Jason G. McCoy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Computational Electrophysiology: The Molecular Dynamics of Ion Channel Permeation and Selectivity in Atomistic Detail

(2011) Carsten Kutzner et al.   BIOPHYSICAL JOURNAL

The pore structure and gating mechanism of K2P channels

(2011) Paula L Piechotta et al.   EMBO JOURNAL

Multiple modalities converge on a common gate to control K2Pchannel function

(2011) Sviatoslav N Bagriantsev et al.   EMBO JOURNAL

Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region

(2011) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Modulation of BKCa Channel Gating by Endogenous Signaling Molecules

(2009) Shangwei Hou et al.   PHYSIOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations

(2008) In Suk Joung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation

(2008) Dina Simkin et al.   JOURNAL OF PHYSIOLOGY-LONDON