A hypothetical molecular mechanism for TRPV1 activation that invokes rotation of an S6 asparagine

Structure of the receptor-activated human TRPC6 and TRPC3 ion channels

(2018) Qinglin Tang et al.   CELL RESEARCH

Optimized expression and purification of NavAb provide the structural insight into the voltage dependence

(2018) Katsumasa Irie et al.   FEBS LETTERS

Ion Channel Sensing: Are Fluctuations the Crux of the Matter?

(2018) Marina A. Kasimova et al.   Journal of Physical Chemistry Letters

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational plasticity in the selectivity filter of the TRPV2 ion channel

(2018) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

(2018) Qiang Su et al.   Nature Communications

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

(2018) Wang Zheng et al.   Nature Communications

Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB

(2018) Appu K. Singh et al.   Nature Communications

Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

(2018) Zengqin Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational plasticity in the selectivity filter of the TRPV2 ion channel

(2018) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM

(2018) Taylor E. T. Hughes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

(2018) Zhe Zhang et al.   eLife

Electron cryo-microscopy structure of the canonical TRPC4 ion channel

(2018) Deivanayagabarathy Vinayagam et al.   eLife

Structure of the human lipid-gated cation channel TRPC3

(2018) Chen Fan et al.   eLife

Cryo-EM structure of the polycystin 2-l1 ion channel

(2018) Raymond E Hulse et al.   eLife

Structure and gating mechanism of the transient receptor potential channel TRPV3

(2018) Appu K. Singh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human PKD1-PKD2 complex

(2018) Qiang Su et al.   SCIENCE

Structure of the mouse TRPC4 ion channel

(2018) Jingjing Duan et al.   Nature Communications

Structural insights on TRPV5 gating by endogenous modulators

(2018) Taylor E. T. Hughes et al.   Nature Communications

Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine

(2017) Andrias O. O’Reilly et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Structures of the calcium-activated, non-selective cation channel TRPM4

(2017) Jiangtao Guo et al.   NATURE

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Human TRPML1 channel structures in open and closed conformations

(2017) Philip Schmiege et al.   NATURE

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3

(2017) Marscha Hirschi et al.   NATURE

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

(2017) Qingfeng Chen et al.   NATURE

Opening of the human epithelial calcium channel TRPV6

(2017) Luke L. McGoldrick et al.   NATURE

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of closed and open states of a voltage-gated sodium channel

(2017) Michael J. Lenaeus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Structure of the cold- and menthol-sensing ion channel TRPM8

(2017) Ying Yin et al.   SCIENCE

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

The complete structure of an activated open sodium channel

(2017) Altin Sula et al.   Nature Communications

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states

(2017) Xiaoyuan Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

(2017) Martin Wilkes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

(2017) Ximena Steinberg et al.   eLife

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

(2017) Appu K. Singh et al.   Scientific Reports

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs

(2016) Peter S. Shen et al.   CELL

Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET

(2016) William N. Zagotta et al.   JOURNAL OF GENERAL PHYSIOLOGY

Transition metal ion FRET to measure short-range distances at the intracellular surface of the plasma membrane

(2016) Sharona E. Gordon et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

(2016) Lin Tang et al.   NATURE

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution

(2016) Jianping Wu et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the full-length TRPV2 channel by cryo-EM

(2016) Kevin W. Huynh et al.   Nature Communications

Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch

(2016) Sara L. Morales-Lázaro et al.   Nature Communications

Cryo-electron microscopy structure of the TRPV2 ion channel

(2016) Lejla Zubcevic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

(2016) Mariana Grieben et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An external sodium ion binding site controls allosteric gating in TRPV1 channels

(2016) Andres Jara-Oseguera et al.   eLife

Comparative sequence analysis suggests a conserved gating mechanism for TRP channels

(2015) Eugene Palovcak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of the TRPA1 ion channel suggests regulatory mechanisms

(2015) Candice E. Paulsen et al.   NATURE

Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel

(2015) Fan Yang et al.   Nature Chemical Biology

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Phosphoinositide regulation of TRPV1 revisited

(2015) Tibor Rohacs   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin

(2015) Khaled Elokely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the voltage-gated calcium channel Cav1.1 complex

(2015) J. Wu et al.   SCIENCE

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Binding to Transient Receptor Potential V1 (TRPV1) Channels

(2014) Horacio Poblete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promiscuous Activation of Transient Receptor Potential Vanilloid 1 (TRPV1) Channels by Negatively Charged Intracellular Lipids

(2013) Viktor Lukacs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Alternative Conformations of a Voltage-Gated Sodium Channel

(2013) Ching-Ju Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

(2012) Jian Payandeh et al.   NATURE

Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

(2011) Giovanni Picazo-Juárez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

The Use of Coumarins as Environmentally-Sensitive Fluorescent Probes of Heterogeneous Inclusion Systems

(2009) Brian Wagner   MOLECULES

Structural determinants of gating in the TRPV1 channel

(2009) Héctor Salazar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY