Dietary Fructose and the Metabolic Syndrome

Dietary Fructose and Microbiota-Derived Short-Chain Fatty Acids Promote Bacteriophage Production in the Gut Symbiont Lactobacillus reuteri

(2019) Jee-Hwan Oh et al.   Cell Host & Microbe

Effects of Dietary Protein and Fat Content on Intrahepatocellular and Intramyocellular Lipids during a 6-Day Hypercaloric, High Sucrose Diet: A Randomized Controlled Trial in Normal Weight Healthy Subjects

(2019) Anna Surowska et al.   Nutrients

From sugar to liver fat and public health: systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesis

(2019) J. Bernadette Moore   PROCEEDINGS OF THE NUTRITION SOCIETY

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Nonalcoholic Fatty Liver Disease and the Heart

(2019) Eric P. Stahl et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Isocaloric Fructose Restriction Reduces Serum D-Lactate Concentration in Children With Obesity and Metabolic Syndrome

(2019) Ayca Erkin-Cakmak et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-Term Consumption of Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Mortality in US Adults

(2019) Vasanti S. Malik et al.   CIRCULATION

Sugar and Fatty Acids Ack-celerate Prophage Induction

(2019) Anushila Chatterjee et al.   Cell Host & Microbe

Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps

(2019) Raul D. Santos et al.   ATHEROSCLEROSIS

Emerging Evidence that ApoC-III Inhibitors Provide Novel Options to Reduce the Residual CVD

(2019) Marja-Riitta Taskinen et al.   Current Atherosclerosis Reports

Intestinal lipogenesis

(2019) Simon Hoffman et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Role of apolipoprotein C‐III overproduction in diabetic dyslipidaemia

(2019) Martin Adiels et al.   DIABETES OBESITY & METABOLISM

Intestinal Absorption of Fructose

(2018) Ronaldo P. Ferraris et al.   Annual Review of Nutrition

Dietary Fructose Metabolism By Splanchnic Organs: Size Matters

(2018) Javier T. Gonzalez et al.   Cell Metabolism

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

(2018) Cholsoon Jang et al.   Cell Metabolism

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

(2018) Adil Mardinoglu et al.   Cell Metabolism

Cardiovascular and Metabolic Heterogeneity of Obesity

(2018) Ian J. Neeland et al.   CIRCULATION

Dietary carbohydrates and fatty liver disease

(2018) Sally Chiu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Relevance of human fat distribution on lipid and lipoprotein metabolism and cardiovascular disease risk

(2018) Marie-Eve Piché et al.   CURRENT OPINION IN LIPIDOLOGY

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease: a systematic review and meta-analysis

(2018) Farzaneh Asgari-Taee et al.   EUROPEAN JOURNAL OF NUTRITION

Fructose metabolism and metabolic disease

(2018) Sarah A. Hannou et al.   JOURNAL OF CLINICAL INVESTIGATION

Fructose-containing caloric sweeteners as a cause of obesity and metabolic disorders

(2018) Luc Tappy   JOURNAL OF EXPERIMENTAL BIOLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

(2018) Thomas Jensen et al.   JOURNAL OF HEPATOLOGY

Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories

(2018) K. L. Stanhope et al.   Obesity Reviews

Application of Magnetic Resonance Spectroscopy in metabolic research

(2018) Tineke van de Weijer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Real-world data reveal a diagnostic gap in non-alcoholic fatty liver disease

(2018) Myriam Alexander et al.   BMC Medicine

Low-Calorie Sweetened Beverages and Cardiometabolic Health: A Science Advisory From the American Heart Association

(2018) Rachel K. Johnson et al.   CIRCULATION

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

French Recommendations for Sugar Intake in Adults: A Novel Approach Chosen by ANSES

(2018) Luc Tappy et al.   Nutrients

Sugar-Sweetened Soft Drinks and Fructose Consumption Are Associated with Hyperuricemia: Cross-Sectional Analysis from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

(2018) Jordana Siqueira et al.   Nutrients

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

(2018) Norbert Stefan et al.   Lancet Diabetes & Endocrinology

Metabolic health in normal-weight and obese individuals

(2018) Matthias B. Schulze   DIABETOLOGIA

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Crosstalk between nonalcoholic fatty liver disease and cardiometabolic syndrome

(2018) Soo Lim et al.   Obesity Reviews

Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease

(2017) Peter Mirtschink et al.   EUROPEAN HEART JOURNAL

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity

(2017) Jean-Marc Schwarz et al.   GASTROENTEROLOGY

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

(2017) Samir Softic et al.   JOURNAL OF CLINICAL INVESTIGATION

Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity

(2017) M.-R. Taskinen et al.   JOURNAL OF INTERNAL MEDICINE

More pieces of the fructose puzzle

(2017) K. L. Stanhope   JOURNAL OF INTERNAL MEDICINE

NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children

(2017) Miriam B. Vos et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia

(2017) Shujun Zhang et al.   MEDICINE

Health Effects of Overweight and Obesity in 195 Countries over 25 Years

(2017)   NEW ENGLAND JOURNAL OF MEDICINE

Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study

(2017) Chao Yang et al.   PLoS One

Impact of fat mass and distribution on lipid turnover in human adipose tissue

(2017) Kirsty L. Spalding et al.   Nature Communications

Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease

(2017) et al.   Nutrients

Fructose and NAFLD: The Multifaceted Aspects of  Fructose Metabolism

(2017) Prasanthi Jegatheesan et al.   Nutrients

Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review

(2017) Cristiana Caliceti et al.   Nutrients

Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease

(2017) Jessica Lambertz et al.   Frontiers in Immunology

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

(2017) ffolliott M. Fisher et al.   Molecular Metabolism

Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review

(2017) Erdi Sozen et al.   Redox Biology

Short-term isocaloric fructose restriction lowers apoC-III levels and yields less atherogenic lipoprotein profiles in children with obesity and metabolic syndrome

(2016) Alejandro Gugliucci et al.   ATHEROSCLEROSIS

Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease

(2016) Prasanthi Jegatheesan et al.   CLINICAL NUTRITION

Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?

(2016) Marja-Riitta Taskinen et al.   Current Atherosclerosis Reports

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016) et al.   DIABETOLOGIA

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

Uric acid in metabolic syndrome: From an innocent bystander to a central player

(2016) Mehmet Kanbay et al.   European Journal of Internal Medicine

Dicarbonyl stress in clinical obesity

(2016) Jinit Masania et al.   GLYCOCONJUGATE JOURNAL

ChREBP regulates fructose-induced glucose production independently of insulin signaling

(2016) Mi-Sung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease

(2016) Sabina Paglialunga et al.   Lipids in Health and Disease

Serum uric acid: A strong and independent predictor of metabolic syndrome after adjusting for body composition

(2016) Tae Yang Yu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High serum uric acid levels increase the risk of metabolic syndrome in elderly women: The PRO.V.A study

(2016) A. Zurlo et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis

(2016) Mark A. Herman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Added Sugars Intake Across the Distribution of US Children and Adult Consumers: 1977-2012

(2016) Elyse S. Powell et al.   Journal of the Academy of Nutrition and Dietetics

A dose-response study of consuming high-fructose corn syrup–sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults

(2015) Kimber L Stanhope et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal ObesitySignificance

(2015) Jan Borén et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sugar consumption, metabolic disease and obesity: The state of the controversy

(2015) Kimber L. Stanhope   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Obesity and cardiovascular disease: friend or foe?

(2015) Seong Hwan Kim et al.   EUROPEAN HEART JOURNAL

Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption

(2015) Chirag Patel et al.   FASEB JOURNAL

Serum Uric Acid Levels and Risk of Metabolic Syndrome: A Dose-Response Meta-Analysis of Prospective Studies

(2015) Huiping Yuan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat

(2015) Jean-Marc Schwarz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts

(2015) Jiantao Ma et al.   JOURNAL OF HEPATOLOGY

Fructose and Cardiometabolic Health

(2015) Vasanti S. Malik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study

(2015) N. Babio et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: A Meta-analysis of Prospective Studies

(2015) Zhengtao Liu et al.   Scientific Reports

De novo lipogenesis in metabolic homeostasis: More friend than foe?

(2015) Giovanni Solinas et al.   Molecular Metabolism

Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study

(2015) Hai-Lun Sun et al.   PLoS One

Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis

(2014) Mei Chung et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sweetened beverage consumption and the risk of hyperuricemia in Mexican adults: a cross-sectional study

(2014) Joacim Meneses-Leon et al.   BMC PUBLIC HEALTH

Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials

(2014) S Chiu et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

A possible role of serum uric acid as a marker of metabolic syndrome

(2014) Y.-J. Lee et al.   INTERNAL MEDICINE JOURNAL

Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

(2014) Fredrik Karpe et al.   Nature Reviews Endocrinology

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Novel Role of Enteral Monosaccharides in Intestinal Lipoprotein Production in Healthy Humans

(2013) Changting Xiao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sugar, Uric Acid, and the Etiology of Diabetes and Obesity

(2013) R. J. Johnson et al.   DIABETES

No Difference Between High-Fructose and High-Glucose Diets on Liver Triacylglycerol or Biochemistry in Healthy Overweight Men

(2013) Richard D. Johnston et al.   GASTROENTEROLOGY

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

Dietary fructose in nonalcoholic fatty liver disease

(2013) Miriam B. Vos et al.   HEPATOLOGY

Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans

(2013) V. Lecoultre et al.   Obesity

Higher consumption of sugar-sweetened soft drinks increases the risk of hyperuricemia in Korean population: The Korean Multi-Rural Communities Cohort Study

(2013) Jisuk Bae et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The Unfolded Protein Response in Fatty Liver Disease

(2013) Richard Green et al.   SEMINARS IN LIVER DISEASE

Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans

(2012) Fanny Theytaz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

(2012) Ksenia Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes

(2012) Manal F. Abdelmalek et al.   HEPATOLOGY

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

(2012) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effects of Fructose Intake on Serum Uric Acid Vary among Controlled Dietary Trials

(2012) D. David Wang et al.   JOURNAL OF NUTRITION

Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey

(2012) Jeffrey C. Sirota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans

(2012) Chad L Cox et al.   Nutrition & Metabolism

Fructose metabolism in humans – what isotopic tracer studies tell us

(2012) Sam Z Sun et al.   Nutrition & Metabolism

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study

(2011) Maria Maersk et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of Fructose-Containing Sugars in the Epidemics of Obesity and Metabolic Syndrome

(2011) Kimber L. Stanhope   Annual Review of Medicine

Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial

(2011) Guenther Silbernagel et al.   BRITISH JOURNAL OF NUTRITION

Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women

(2011) C L Cox et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects

(2011) Sven Haufe et al.   HEPATOLOGY

Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy

(2011) Scott B. Reeder et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Fructose consumption: recent results and their potential implications

(2010) Kimber L. Stanhope et al.   Annals of the New York Academy of Sciences

Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men

(2010) H. Sobrecases et al.   DIABETES & METABOLISM

Epidemiology of Non-Alcoholic Fatty Liver Disease

(2010) Stefano Bellentani et al.   DIGESTIVE DISEASES

Serum Uric Acid as a Predictor for the Development of Nonalcoholic Fatty Liver Disease in Apparently Healthy Subjects: A 5-Year Retrospective Cohort Study

(2010) Jae Woong Lee et al.   Gut and Liver

Caloric Sweetener Consumption and Dyslipidemia Among US Adults

(2010) Jean A. Welsh   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Fructose-Rich Beverages and Risk of Gout in Women

(2010) Hyon K. Choi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Non-invasive assessment of hepatic steatosis: Prospective comparison of the accuracy of imaging examinations

(2010) Seung Soo Lee et al.   JOURNAL OF HEPATOLOGY

Metabolic Effects of Fructose and the Worldwide Increase in Obesity

(2010) Luc Tappy et al.   PHYSIOLOGICAL REVIEWS

High Serum Uric Acid Increases the Risk for Nonalcoholic Fatty Liver Disease: A Prospective Observational Study

(2010) Chengfu Xu et al.   PLoS One

Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes

(2009) Kim-Anne Lê et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of a short-term overfeeding with fructose or glucose in healthy young males

(2009) Emilienne Tudor Ngo Sock et al.   BRITISH JOURNAL OF NUTRITION

Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction

(2009) Erik Kirk et al.   GASTROENTEROLOGY

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans

(2009) Kimber L. Stanhope et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study

(2009) Youming Li et al.   JOURNAL OF HEPATOLOGY

Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis

(2009) Michael K. Pickens et al.   JOURNAL OF LIPID RESEARCH

Sugar-Sweetened Beverages, Serum Uric Acid, and Blood Pressure in Adolescents

(2009) Stephanie Nguyen et al.   JOURNAL OF PEDIATRICS

Fructose and carbonyl metabolites as endogenous toxins

(2008) O. Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Causes and Metabolic Consequences of Fatty Liver

(2008) Norbert Stefan et al.   ENDOCRINE REVIEWS

Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease

(2008) Hironori Mitsuyoshi et al.   HEPATOLOGY RESEARCH

Fructose consumption as a risk factor for non-alcoholic fatty liver disease

(2008) Xiaosen Ouyang et al.   JOURNAL OF HEPATOLOGY

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE