Bcl-2-regulated cell death signalling in the prevention of autoimmunity

Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis

(2010) John C. Scatizzi et al.   ARTHRITIS AND RHEUMATISM

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

A Novel TCR Transgenic Model Reveals That Negative Selection Involves an Immediate, Bim-Dependent Pathway and a Delayed, Bim-Independent Pathway

(2010) Damian Kovalovsky et al.   PLoS One

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

Critical roles of Bim in T cell activation and T cell–mediated autoimmune inflammation in mice

(2009) Maciej W. Ludwinski et al.   JOURNAL OF CLINICAL INVESTIGATION

Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens

(2009) Q. Hu et al.   JOURNAL OF IMMUNOLOGY

Analysis of Adhesion Molecules, Target Cells, and Role of IL-2 in Human FOXP3+ Regulatory T Cell Suppressor Function

(2009) D. Q. Tran et al.   JOURNAL OF IMMUNOLOGY

The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity

(2009) P. D. Bardwell et al.   JOURNAL OF IMMUNOLOGY

Functional Cooperation of the Proapoptotic Bcl2 Family Proteins Bmf and Bim In Vivo

(2009) A. Hubner et al.   MOLECULAR AND CELLULAR BIOLOGY

Checkpoints in lymphocyte development and autoimmune disease

(2009) Harald von Boehmer et al.   NATURE IMMUNOLOGY

Interleukin 17 acts in synergy with B cell–activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus

(2009) Agnès Doreau et al.   NATURE IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Function of CD4+,CD25+ Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells

(2008) Véronique Parietti et al.   ARTHRITIS AND RHEUMATISM

The control of CD4+CD25+Foxp3+ regulatory T cell survival

(2008) Pushpa Pandiyan et al.   Biology Direct

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

(2008) Peter D. Hughes et al.   IMMUNITY

Apoptosis Regulators Bim and Fas Function Concurrently to Control Autoimmunity and CD8+ T Cell Contraction

(2008) Ashley E. Weant et al.   IMMUNITY

Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity

(2008) Jack Hutcheson et al.   IMMUNITY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

No requirement for TRAIL in intrathymic negative selection

(2008) Erika Cretney et al.   INTERNATIONAL IMMUNOLOGY

During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain

(2008) Jennifer Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

(2008) Verena Labi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expansion and evolution of cell death programmes

(2008) Alexei Degterev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection

(2008) S. F. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

(2008) Jerry E. Chipuk et al.   TRENDS IN CELL BIOLOGY

Bcl-2 Protein Family Members: Versatile Regulators of Calcium Signaling in Cell Survival and Apoptosis

(2007) Yiping Rong et al.   Annual Review of Physiology

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY