Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Mohammed Gamah, Murad Alahdal, Yu Zhang, Yiling Zhou, Qiaorong Ji, Zhouyang Yuan, Ying Han, Xiangqun Shen, Yanming Ren, Wei Zhang
Summary: This study found that high altitude hypoxia exacerbates the severity of ulcerative colitis in mice by activating the increase of inflammatory Th1 and Th17 lymphocytes.
Article
Gastroenterology & Hepatology
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang, Lei Shi
Summary: The study reveals the differential intestinal microbiota and metabolites in the pathogenesis of ulcerative colitis (UC), suggesting that different microbiota and metabolites may cause varying degrees of colitis. Some microbiota and metabolites may have protective roles against colitis, influencing the composition and function of intestinal mucus barrier under colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Plant Sciences
Huibiao Li, Xiaohong Chen, Jiayao Liu, Muyuan Chen, Ming Huang, Guoxin Huang, Xinlin Chen, Qin Du, Jiyan Su, Rongfeng Lin
Summary: The study found that Centella asiatica ethanol extract significantly reduced inflammation in mice with UC, alleviating symptoms of colitis and potentially serving as an effective treatment in clinical practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiahui Zheng, Huan Li, Pei Zhang, Shijun Yue, Bingtao Zhai, Junbo Zou, Jiangxue Cheng, Chongbo Zhao, Dongyan Guo, Jing Wang
Summary: This study investigated the effects of paeonol (Pae) on colonic inflammation in a mouse model of ulcerative colitis (UC). The results showed that Pae significantly improved the clinical symptoms of UC, restored the integrity of the intestinal epithelial barrier, and regulated the composition of the gut microbiota and metabolites.
Article
Immunology
Yizhuo Wang, Kunjian Liu, Zhiyong Qi, Tong Chen, Wei Yu, Yang Jiang, Guofeng Li, Huijie Xiao
Summary: Camptothecin (CPT) is a cytotoxic alkaloid derived from the bark and branches of the Chinese tree Camptotheca acuminata, with antitumor activities mainly used in colon, ovarian, liver, and bone cancers as well as leukemia treatment. CPT has been shown to protect against ulcerative colitis, reducing disease activity index and inflammatory cytokines, indicating its potential as a therapeutic agent for UC.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Hao Cheng, Juan Liu, Dandan Zhang, Jing Wang, Yuzhu Tan, Wuwen Feng, Cheng Peng
Summary: This study found that ginsenoside Rg1 has pharmacological effects in treating acute colitis mice, which can protect the intestinal barrier and alleviate colon inflammation. The underlying mechanism may be closely related to the regulation of gut microbiota composition and microbial tryptophan metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Do Yeong Kweon, Hee Jin Song, Ji Eun Kim, You Jeong Jin, Yu Jeong Roh, Ayun Seol, Ju Min Park, Eun Suk Lee, Won Sik Choi, Dae Youn Hwang
Summary: This study found that Aloe saponaria can improve clinical symptoms and attenuate inflammatory response in UC mice without significant hepatotoxicity or nephrotoxicity.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Huiqin Wang, Jin Huang, Yanan Ding, Jianwu Zhou, Guanzhen Gao, Huan Han, Jingru Zhou, Lijing Ke, Pingfan Rao, Tianbao Chen, Longxin Zhang
Summary: Food incidental nanoparticles may affect human health by regulating gastrointestinal tissue inflammation and gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Xuan-qing Chen, Xiang-yu Lv, Shi-jia Liu
Summary: BTW significantly improved the inflammatory symptoms of mice with acute colitis, and the latent mechanism of BTW may be related to various signaling pathways, including the modulation of intestinal microflora and inflammatory signaling pathways, such as IL-6/STAT3.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Xingwei Xiang, Qihong Jiang, Wan Shao, Jinhong Li, Yufang Zhou, Lin Chen, Shanggui Deng, Bin Zheng, Yufeng Chen
Summary: The study demonstrated the anti-inflammatory effects of shrimp peptide on a DSS-induced mouse model of UC, showing improvements in colitis severity, intestinal barrier integrity, inflammatory cytokines, antioxidant indices, and intestinal flora balance. These findings suggest that shrimp peptide has prophylactic and therapeutic effects on UC, indicating its broad medicinal applications.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemical Research Methods
Kun Liu, Bingjie Jia, Liping Zhou, Lei Xing, Lvying Wu, Yuanyuan Li, Jungang Lu, Lei Zhang, Su Guan
Summary: This study utilized metabolomics and lipidomics to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis, revealing potential mechanisms of treatment. Through serum metabolomics analysis, metabolites associated with treatment outcomes were discovered, alongside identification of dysregulated metabolic pathways in colitis.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Rong Ren, Ai-Qing Zhao, Li Chen, Shan Wu, Wei-Lun Hung, Bini Wang
Summary: In this study, Lactobacillus plantarum JS19 isolated from jiang-shui exhibited strong antioxidant activity. Oral administration of L. plantarum JS19 effectively prevented body weight loss, colon shortening and damage in mice with dextran sulfate sodium-induced colitis. Moreover, L. plantarum JS19 alleviated inflammatory responses, oxidative stress, and rebalanced dysbiosis of gut microbiota. Therefore, L. plantarum JS19 may serve as a promising probiotic for preventing inflammatory bowel disease, specifically ulcerative colitis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Immunology
Ting Liu, Zunxi Ning, Pengyu Liu, Huiyuan Gao
Summary: This study investigated the bioactivity of caesaldekarin e (CA), a cassane diterpenoid isolated from C. bonduc, in dextran sulfate sodium (DSS)-induced experimental colitis. The results showed that CA could ameliorate colitis symptoms, suppress inflammation, maintain intestinal barrier integrity, restore gut microbiota imbalance, and regulate tryptophan metabolism. Thus, CA has the potential to be used as a treatment option for ulcerative colitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Xinge Xu, Jingwei Wu, Yuxin Jin, Kunlun Huang, Yuanyuan Zhang, Zhihong Liang
Summary: This study investigated the effect of S. boulardii and its postbiotics on DSS-induced ulcerative colitis in mice. The results showed that S. boulardii and postbiotics intervention improved colonic shortening and tissue damage, increased the expression of intestinal tight junction protein, reduced the secretion of pro-inflammatory factors, increased the secretion of anti-inflammatory factors, and maintained the homeostasis of intestinal microorganisms. Postbiotics intervention was more effective than probiotics. In conclusion, S. boulardii and its postbiotics effectively alleviate DSS-induced colitis in mice by modulating host immunity and maintaining intestinal homeostasis. Postbiotics are promising next-generation biotherapeutics for ulcerative colitis treatment.