The anticonvulsive Phenhydan® suppresses extrinsic cell death

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

(2018) Emma J. Petrie et al.   Nature Communications

Sphingolipids and lipid rafts: Novel concepts and methods of analysis

(2018) Erhard Bieberich   CHEMISTRY AND PHYSICS OF LIPIDS

Kinase domain dimerization drives RIPK3-dependent necroptosis

(2018) Saravanan Raju et al.   Science Signaling

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

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(2016) M C Tanzer et al.   CELL DEATH AND DIFFERENTIATION

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(2016) Sudan He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

(2015) M. C. Tanzer et al.   BIOCHEMICAL JOURNAL

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

(2015) A Fauster et al.   Cell Death & Disease

RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis

(2014) Conor J. Kearney et al.   FEBS Journal

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Membrane Trafficking of Death Receptors: Implications on Signalling

(2013) Wulf Schneider-Brachert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The β-Subunit of Cholera Toxin has a High Affinity for Ganglioside GM1 Embedded into Solid Supported Lipid Membranes with a Lipid Raft-Like Composition

(2013) G. Margheri et al.   LIPIDS

Biomedical Importance of Indoles

(2013) Nagendra Kaushik et al.   MOLECULES

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

(2012) N Takahashi et al.   Cell Death & Disease

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiepileptic Drug Interactions - Principles and Clinical Implications

(2010) Svein I. Johannessen et al.   Current Neuropharmacology

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Gramicidin-based Fluorescence Assay; for Determining Small Molecules Potential for Modifying Lipid Bilayer Properties

(2010) Helgi I. Ingólfsson et al.   Jove-Journal of Visualized Experiments

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Identification of Flotillin-2, a Major Protein on Lipid Rafts, as a Novel Target of p53 Family Members

(2008) Y. Sasaki et al.   MOLECULAR CANCER RESEARCH