Recent Progress in Lab-On-a-Chip Systems for the Monitoring of Metabolites for Mammalian and Microbial Cell Research

A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine

(2019) Jiesi Feng et al.   NEURON

Microfluidic platforms for cell cultures and investigations

(2019) Maria Laura Coluccio et al.   MICROELECTRONIC ENGINEERING

Automated Droplet-Based Microfluidic Platform for Multiplexed Analysis of Biochemical Markers in Small Volumes

(2019) Diana F. Cedillo-Alcantar et al.   ANALYTICAL CHEMISTRY

Enzymatic method of urea determination in LTCC microfluidic system based on absorption photometry

(2019) E. Remiszewska et al.   SENSORS AND ACTUATORS B-CHEMICAL

Current progress in long-term and continuous cell metabolite detection using microfluidics

(2019) Jiaming Shi et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Microfluidic Brain-on-a-Chip: Perspectives for Mimicking Neural System Disorders

(2019) Mirza Ali Mofazzal Jahromi et al.   MOLECULAR NEUROBIOLOGY

The Stress-Chip: A microfluidic platform for stress analysis in Caenorhabditis elegans

(2019) Stephen A. Banse et al.   PLoS One

Microfluidic-Based Nucleic Acid Amplification Systems in Microbiology

(2019) Lena Gorgannezhad et al.   Micromachines

Two-dimensional nuclear magnetic resonance spectroscopy with a microfluidic diamond quantum sensor

(2019) Janis Smits et al.   Science Advances

Systems Biology and Multi-Omics Integration: Viewpoints from the Metabolomics Research Community

(2019) Farhana R. Pinu et al.   Metabolites

A Complete Protocol for Rapid and Low-Cost Fabrication of Polymer Microfluidic Chips Containing Three-Dimensional Microstructures Used in Point-of-Care Devices

(2019) Trieu Nguyen et al.   Micromachines

Microengineered Bioartificial Liver Chip for Drug Toxicity Screening

(2018) Bahman Delalat et al.   ADVANCED FUNCTIONAL MATERIALS

Downstream Simultaneous Electrochemical Detection of Primary Reactive Oxygen and Nitrogen Species Released by Cell Populations in an Integrated Microfluidic Device

(2018) Yun Li et al.   ANALYTICAL CHEMISTRY

Recent advances in toner-based microfluidic devices for bioanalytical applications

(2018) Ellen F. M. Gabriel et al.   Analytical Methods

Cancer Energy Metabolism: Shutting Power off Cancer Factory

(2018) Soo-Youl Kim   Biomolecules & Therapeutics

Microfluidic devices for sample preparation and rapid detection of foodborne pathogens

(2018) Krishna Kant et al.   BIOTECHNOLOGY ADVANCES

Micro-optics for microfluidic analytical applications

(2018) Hui Yang et al.   CHEMICAL SOCIETY REVIEWS

Biomarker definitions and their applications

(2018) Robert M Califf   EXPERIMENTAL BIOLOGY AND MEDICINE

Microsensor systems for cell metabolism – from 2D culture to organ-on-chip

(2018) Jochen Kieninger et al.   LAB ON A CHIP

Microfluidics Approaches in Modern Developmental Biology

(2018) A. V. Spirov   Russian Journal of Developmental Biology

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

(2018) Khashayar Moshksayan et al.   SENSORS AND ACTUATORS B-CHEMICAL

Pushing nuclear magnetic resonance sensitivity limits with microfluidics and photo-chemically induced dynamic nuclear polarization

(2018) Miguel Mompeán et al.   Nature Communications

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth

(2018) Yonika Arum Larasati et al.   Scientific Reports

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution

(2018) Maria Cristina Letizia et al.   Microsystems & Nanoengineering

Lab-on-a-Chip Technology for Environmental Monitoring of Microorganisms

(2018) Bidhan Chandra Dhar et al.   BioChip Journal

A Multi-Sensor System for Measuring Bovine Embryo Metabolism

(2018) Yusra Obeidat et al.   BIOSENSORS & BIOELECTRONICS

Intracellular Electrochemical Sensing

(2018) Kosuke Ino et al.   ELECTROANALYSIS

Enhanced biosynthesis of phenazine-1-carboxamide by engineered Pseudomonas chlororaphis HT66

(2018) Huasong Peng et al.   Microbial Cell Factories

Different action of nanoencapsulated meso-tetraphenylporphyrin in breast spheroid co-culture and mono-culture under microfluidic conditions

(2018) Agnieszka Zuchowska et al.   SENSORS AND ACTUATORS B-CHEMICAL

An On-Chip SiC MEMS Device with Integrated Heating, Sensing, and Microfluidic Cooling Systems

(2018) Toan Dinh et al.   Advanced Materials Interfaces

Combining Mass Spectrometry and NMR Improves Metabolite Detection and Annotation

(2018) Fatema Bhinderwala et al.   JOURNAL OF PROTEOME RESEARCH

Dissecting the regulation and function of ATP at the single-cell level

(2018) Jianhan Zhang et al.   PLOS BIOLOGY

Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: A review

(2018) Zerong Liao et al.   BIOSENSORS & BIOELECTRONICS

Our microbes not only produce antibiotics, they also overproduce amino acids

(2017) Sergio Sanchez et al.   JOURNAL OF ANTIBIOTICS

Differential detection photothermal spectroscopy: towards ultra-fast and sensitive label-free detection in picoliter & femtoliter droplets

(2017) Richard M. Maceiczyk et al.   LAB ON A CHIP

Why microfluidics? Merits and trends in chemical synthesis

(2017) Yong Liu et al.   LAB ON A CHIP

Droplet-based microfluidic high-throughput screening of heterologous enzymes secreted by the yeast Yarrowia lipolytica

(2017) Thomas Beneyton et al.   Microbial Cell Factories

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lab-on-a-disc platform for screening of genetically modified E. coli cells via cell-free electrochemical detection of p -Coumaric acid

(2017) Kuldeep Sanger et al.   SENSORS AND ACTUATORS B-CHEMICAL

Microfluidic lab-on-a-chip platforms for environmental monitoring

(2017) Roberto Pol et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Point-of-Care Detection Devices for Food Safety Monitoring: Proactive Disease Prevention

(2017) Marie Yung-Chen Wu et al.   TRENDS IN BIOTECHNOLOGY

RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes

(2017) Joseph Abatemarco et al.   Nature Communications

Extractive Fermentation of Lactic Acid in Lactic Acid Bacteria Cultivation: A Review

(2017) Majdiah Othman et al.   Frontiers in Microbiology

Detecting cell-secreted growth factors in microfluidic devices using bead-based biosensors

(2017) Kyung Jin Son et al.   Microsystems & Nanoengineering

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

(2017) Fang Yu et al.   Scientific Reports

Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells

(2016) Kyung Jin Son et al.   ANALYST

Droplet Microfluidic Platform for the Determination of Single-Cell Lactate Release

(2016) Amy Mongersun et al.   ANALYTICAL CHEMISTRY

Multicolor Fluorescence Detection-Based Microfluidic Device for Single-Cell Metabolomics: Simultaneous Quantitation of Multiple Small Molecules in Primary Liver Cells

(2016) Qingling Li et al.   ANALYTICAL CHEMISTRY

Microfluidics for High-Throughput Quantitative Studies of Early Development

(2016) Thomas J. Levario et al.   Annual Review of Biomedical Engineering

Determination of cell metabolite VEGF 165 and dynamic analysis of protein–DNA interactions by combination of microfluidic technique and luminescent switch-on probe

(2016) Xuexia Lin et al.   BIOSENSORS & BIOELECTRONICS

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

(2016) Volker M. Lauschke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

(2016) Kathy K. Griendling et al.   CIRCULATION RESEARCH

Multi-chambers Microsystem for Simultaneous and Direct Electrochemical Detection of Reactive Oxygen and Nitrogen Species Released by Cell Populations

(2016) Yun Li et al.   ELECTROANALYSIS

Lab-on-chip systems for integrated bioanalyses

(2016) J. P. Conde et al.   Essays in Biochemistry

Electrochemical biosensors and nanobiosensors

(2016) J. L. Hammond et al.   Essays in Biochemistry

Microfluidics in microbiology: putting a magnifying glass on microbes

(2016) Sanya Siddiqui et al.   Integrative Biology

Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species

(2016) S. F. Moussavi-Harami et al.   Integrative Biology

An optimised detector for in-situ high-resolution NMR in microfluidic devices

(2016) Graeme Finch et al.   JOURNAL OF MAGNETIC RESONANCE

On-chip analysis, indexing and screening for chemical producing bacteria in a microfluidic static droplet array

(2016) Sungho Jang et al.   LAB ON A CHIP

New insights into ROS dynamics: a multi-layered microfluidic chip for ecotoxicological studies on aquatic microorganisms

(2016) Volodymyr B. Koman et al.   Nanotoxicology

Integrated multi-sensor system for parallel in-situ monitoring of cell nutrients, metabolites, cell density and pH in biotechnological processes

(2016) Stefan Mross et al.   SENSORS AND ACTUATORS B-CHEMICAL

ROS homeostasis and metabolism: a dangerous liason in cancer cells

(2016) E Panieri et al.   Cell Death & Disease

Electrochemical camera chip for simultaneous imaging of multiple metabolites in biofilms

(2016) Daniel L. Bellin et al.   Nature Communications

Broad-Host-Range ProUSER Vectors Enable Fast Characterization of Inducible Promoters and Optimization of p-Coumaric Acid Production in Pseudomonas putida KT2440

(2016) Patricia Calero et al.   ACS Synthetic Biology

Challenges and Opportunities of Centrifugal Microfluidics for Extreme Point-of-Care Testing

(2016) Issac Michael et al.   Micromachines

Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production

(2016) Chia-Wen Tsao   Micromachines

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

(2016) Patrick M. Misun et al.   Microsystems & Nanoengineering

A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments

(2016) Anthony C. Dona et al.   Computational and Structural Biotechnology Journal

Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers

(2016) Reza Riahi et al.   Scientific Reports

Consecutive Gated Injection-Based Microchip Electrophoresis for Simultaneous Quantitation of Superoxide Anion and Nitric Oxide in Single PC-12 Cells

(2015) Lu Li et al.   ANALYTICAL CHEMISTRY

Reconfigurable microfluidic device with integrated antibody arrays for capture, multiplexed stimulation, and cytokine profiling of human monocytes

(2015) Tam Vu et al.   Biomicrofluidics

Superoxide microsensor integrated into a Sensing Cell Culture Flask microsystem using direct oxidation for cell culture application

(2015) H. Flamm et al.   BIOSENSORS & BIOELECTRONICS

Detecting multiple cell-secreted cytokines from the same aptamer-functionalized electrode

(2015) Ying Liu et al.   BIOSENSORS & BIOELECTRONICS

A high sensitive electrochemical aptasensor for the determination of VEGF 165 in serum of lung cancer patient

(2015) Mahmoud Amouzadeh Tabrizi et al.   BIOSENSORS & BIOELECTRONICS

Electrochemistry, biosensors and microfluidics: a convergence of fields

(2015) Darius G. Rackus et al.   CHEMICAL SOCIETY REVIEWS

Microscale microbial culture

(2015) Anand Srinivasan et al.   Future Microbiology

A microsystem integrating photodegradable hydrogel microstructures and reconfigurable microfluidics for single-cell analysis and retrieval

(2015) Kyung Jin Son et al.   LAB ON A CHIP

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

Enzyme SU-8 microreactors: simple tools for cell-culture monitoring

(2015) Sara Talaei et al.   Microfluidics and Nanofluidics

Phenazine derivatives cause proteotoxicity and stress in C. elegans

(2015) Arpita Ray et al.   NEUROSCIENCE LETTERS

ZnO Nanostructure-Based Intracellular Sensor

(2015) Muhammad Asif et al.   SENSORS

CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation

(2015) X. Han et al.   Science Advances

Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer

(2014) Jong-Min Lim et al.   ACS Nano

Fabricating a reversible and regenerable electrochemical biosensor for quantitative detection of antibody by using “triplex-stem” DNA molecular switch

(2014) Wei Wei et al.   ANALYTICA CHIMICA ACTA

Continuous and Simultaneous Electrochemical Measurements of Glucose, Lactate, and Ascorbate in Rat Brain Following Brain Ischemia

(2014) Yuqing Lin et al.   ANALYTICAL CHEMISTRY

Detecting Transforming Growth Factor-β Release from Liver Cells Using an Aptasensor Integrated with Microfluidics

(2014) Zimple Matharu et al.   ANALYTICAL CHEMISTRY

Long-term microfluidic glucose and lactate monitoring in hepatic cell culture

(2014) Sebastian Prill et al.   Biomicrofluidics

Extracellular nucleotide and nucleoside signaling in vascular and blood disease

(2014) M. Idzko et al.   BLOOD

Electrochemical Detection of Nitric Oxide and Peroxynitrite Anion in Microchannels at Highly Sensitive Platinum-Black Coated Electrodes. Application to ROS and RNS Mixtures prior to Biological Investigations

(2014) Yun Li et al.   ELECTROCHIMICA ACTA

Reconfigurable microfluidics with integrated aptasensors for monitoring intercellular communication

(2014) Timothy Kwa et al.   LAB ON A CHIP

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Materials for Microfluidic Chip Fabrication

(2013) Kangning Ren et al.   ACCOUNTS OF CHEMICAL RESEARCH

Electrochemical Nanoprobes for Single-Cell Analysis

(2013) Paolo Actis et al.   ACS Nano

Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications

(2013) Lorenzo Capretto et al.   ADVANCED DRUG DELIVERY REVIEWS

Highly Sensitive Platinum-Black Coated Platinum Electrodes for Electrochemical Detection of Hydrogen Peroxide and Nitrite in Microchannel

(2013) Yun Li et al.   ELECTROANALYSIS

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

A microfluidic platform for chemical stimulation and real time analysis of catecholamine secretion from neuroendocrine cells

(2013) Igor A. Ges et al.   LAB ON A CHIP

High-throughput metabolic genotoxicity screening with a fluidic microwell chip and electrochemiluminescence

(2013) Dhanuka P. Wasalathanthri et al.   LAB ON A CHIP

Cell chips as new tools for cell biology – results, perspectives and opportunities

(2013) Elisabetta Primiceri et al.   LAB ON A CHIP

Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem

(2013) Andreas Weltin et al.   LAB ON A CHIP

On-chip regeneration of aptasensors for monitoring cell secretion

(2013) Qing Zhou et al.   LAB ON A CHIP

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

A vector-free microfluidic platform for intracellular delivery

(2013) A. Sharei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia

(2012) Xianchan Li et al.   ANALYTICAL CHEMISTRY

Miniature Enzyme-Based Electrodes for Detection of Hydrogen Peroxide Release from Alcohol-Injured Hepatocytes

(2012) Zimple Matharu et al.   ANALYTICAL CHEMISTRY

Potential of Mid-Infrared Spectroscopy for On-Line Monitoring of Mammalian Cell Culture Medium Components

(2012) Róisín Foley et al.   APPLIED SPECTROSCOPY

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

Effects of Redox Couple on the Response of Polypyrrole-Based Electrochemical DNA Sensors

(2012) Marsilea Adela Booth et al.   ELECTROANALYSIS

Real time culture and analysis of embryo metabolism using a microfluidic device with deformation based actuation

(2012) Yun Seok Heo et al.   LAB ON A CHIP

Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices

(2012) YongTae Kim et al.   NANO LETTERS

Simultaneous Optical Recording in Multiple Cells by Digital Holographic Microscopy of Chloride Current Associated to Activation of the Ligand-Gated Chloride Channel GABAA Receptor

(2012) Pascal Jourdain et al.   PLoS One

Electrochemical detection of catecholamine release using planar iridium oxide electrodes in nanoliter microfluidic cell culture volumes

(2011) Igor A. Ges et al.   BIOSENSORS & BIOELECTRONICS

Toxicity of nanomaterials

(2011) Shahriar Sharifi et al.   CHEMICAL SOCIETY REVIEWS

Electrokinetic gated injection-based microfluidic system for quantitative analysis of hydrogen peroxide in individual HepG2 cells

(2011) Xinyuan Zhang et al.   LAB ON A CHIP

Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations

(2011) L. K. Chin et al.   LAB ON A CHIP

Microfluidic devices as tools for mimicking the in vivo environment

(2011) Karina Ziółkowska et al.   NEW JOURNAL OF CHEMISTRY

Microfluidic analytical systems for food analysis

(2011) Yegermal T. Atalay et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

The Role of ATP in Sleep Regulation

(2011) Sachiko Chikahisa et al.   Frontiers in Neurology

Enzyme-coated microelectrodes to monitor lactate production in a nanoliter microfluidic cell culture device

(2010) Igor A. Ges et al.   BIOSENSORS & BIOELECTRONICS

Albumin and mammalian cell culture: implications for biotechnology applications

(2010) Geoffrey L. Francis   CYTOTECHNOLOGY

Long-term high-resolution imaging and culture of C. elegans in chip-gel hybrid microfluidic device for developmental studies

(2010) Jan Krajniak et al.   LAB ON A CHIP

Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species

(2010) Lih-Tyng Cheah et al.   LAB ON A CHIP

Review: Microfluidic applications in metabolomics and metabolic profiling

(2009) James R. Kraly et al.   ANALYTICA CHIMICA ACTA

Microfluidic chip: Next-generation platform for systems biology

(2009) Xiaojun Feng et al.   ANALYTICA CHIMICA ACTA

Simultaneous Determination of Superoxide and Hydrogen Peroxide in Macrophage RAW 264.7 Cell Extracts by Microchip Electrophoresis with Laser-Induced Fluorescence Detection

(2009) Hongmin Li et al.   ANALYTICAL CHEMISTRY

Detection of hormone active chemicals using genetically engineered yeast cells and microfluidic devices with interdigitated array electrodes

(2009) Kosuke Ino et al.   ELECTROPHORESIS

Noninvasive Metabolic Profiling Using Microfluidics for Analysis of Single Preimplantation Embryos

(2008) John Paul Urbanski et al.   ANALYTICAL CHEMISTRY

Microfluidics: Applications for analytical purposes in chemistry and biochemistry

(2008) Ken-ichi Ohno et al.   ELECTROPHORESIS

A microdevice for multiplexed detection of T-cell-secreted cytokines

(2008) He Zhu et al.   LAB ON A CHIP

Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation

(2008) Fei Zeng et al.   LAB ON A CHIP