Why microfluidics? Merits and trends in chemical synthesis

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

(2017) Josef J. Heiland et al.   LAB ON A CHIP

On-chip integration of droplet microfluidics and nanostructure-initiator mass spectrometry for enzyme screening

(2017) Joshua Heinemann et al.   LAB ON A CHIP

An automated and portable microfluidic chemiluminescence immunoassay for quantitative detection of biomarkers

(2017) Binfeng Hu et al.   LAB ON A CHIP

High-throughput screening of microchip-synthesized genes in programmable double-emulsion droplets

(2017) H. F. Chan et al.   Nanoscale

High thermal conductivity in soft elastomers with elongated liquid metal inclusions

(2017) Michael D. Bartlett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

(2017) Yifeng Lei et al.   Nature Communications

Feedback in Flow for Accelerated Reaction Development

(2016) Brandon J. Reizman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Superamphiphobic Silicon-Nanowire-Embedded Microsystem and In-Contact Flow Performance of Gas and Liquid Streams

(2016) Dong-Hyeon Ko et al.   ACS Nano

Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification

(2016) Can Xu et al.   ADVANCED MATERIALS

Simple Spinning of Heterogeneous Hollow Microfibers on Chip

(2016) Yue Yu et al.   ADVANCED MATERIALS

Nonspecific Organelle-Targeting Strategy with Core–Shell Nanoparticles of Varied Lipid Components/Ratios

(2016) Lu Zhang et al.   ANALYTICAL CHEMISTRY

Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes

(2016) Stefan Roesner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3D-Printed Microfluidics

(2016) Anthony K. Au et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Taming hazardous chemistry by continuous flow technology

(2016) M. Movsisyan et al.   CHEMICAL SOCIETY REVIEWS

The fabrication and characterization of a PLGA nanoparticle–Pheroid® combined drug delivery system

(2016) Madichaba P. Chelopo et al.   JOURNAL OF MATERIALS SCIENCE

Compartmentalized Droplets for Continuous Flow Liquid–Liquid Interface Catalysis

(2016) Ming Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On-chip automation of cell-free protein synthesis: new opportunities due to a novel reaction mode

(2016) V. Georgi et al.   LAB ON A CHIP

Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip

(2016) Carsten Lotter et al.   LAB ON A CHIP

Synthesis of Cesium Lead Halide Perovskite Nanocrystals in a Droplet-Based Microfluidic Platform: Fast Parametric Space Mapping

(2016) Ioannis Lignos et al.   NANO LETTERS

Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications

(2016) Qiang Feng et al.   Nanoscale

Flow chemistry and polymer-supported pseudoenantiomeric acylating agents enable parallel kinetic resolution of chiral saturated N-heterocycles

(2016) Imants Kreituss et al.   Nature Chemistry

Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing

(2016) H. Kim et al.   SCIENCE

Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening

(2016) Zhuofa Chen et al.   SENSORS

One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance

(2016) Qiang Feng et al.   Small

Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry

(2016) Ajay K. Singh et al.   Nature Communications

Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

(2016) Sudip Mondal et al.   Nature Communications

Combinatorial microfluidic droplet engineering for biomimetic material synthesis

(2016) L. A. Bawazer et al.   Science Advances

Suzuki–Miyaura cross-coupling optimization enabled by automated feedback

(2016) Brandon J. Reizman et al.   Reaction Chemistry & Engineering

Optofluidic UV-Vis spectrophotometer for online monitoring of photocatalytic reactions

(2016) Ning Wang et al.   Scientific Reports

Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell–Nanoparticle Interaction

(2015) Lu Zhang et al.   ACS Nano

A Versatile and Robust Microfluidic Platform Toward High Throughput Synthesis of Homogeneous Nanoparticles with Tunable Properties

(2015) Dongfei Liu et al.   ADVANCED MATERIALS

A High-Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors

(2015) Yang Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microfluidic Synthesis of Rigid Nanovesicles for Hydrophilic Reagents Delivery

(2015) Lu Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters

(2015) Qiang Feng et al.   Biomicrofluidics

On-chip monitoring of chemical syntheses in microdroplets via surface-enhanced Raman spectroscopy

(2015) T.-A. Meier et al.   CHEMICAL COMMUNICATIONS

Morphology-controlled synthesis of Ag nanoparticle decorated poly(o-phenylenediamine) using microfluidics and its application for hydrogen peroxide detection

(2015) Lei Wang et al.   CHEMICAL ENGINEERING JOURNAL

On-Demand One-Step Synthesis of Monodisperse Functional Polymeric Microspheres with Droplet Microfluidics

(2015) Xu Yu et al.   LANGMUIR

High-Throughput Continuous Flow Production of Nanoscale Liposomes by Microfluidic Vertical Flow Focusing

(2015) Renee R. Hood et al.   Small

A Versatile Microfluidic Device for Automating Synthetic Biology

(2015) Steve C. C. Shih et al.   ACS Synthetic Biology

Strategic Application of Residence-Time Control in Continuous-Flow Reactors

(2015) István M. Mándity et al.   ChemistryOpen

Online detection and automation methods in microfluidic nanomaterial synthesis

(2015) Richard M Maceiczyk et al.   Current Opinion in Chemical Engineering

Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer

(2014) Jong-Min Lim et al.   ACS Nano

Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake

(2014) Jiashu Sun et al.   ADVANCED MATERIALS

Integrated One-Flow Synthesis of Heterocyclic Thioquinazolinones through Serial Microreactions with Two Organolithium Intermediates

(2014) Heejin Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactions of Difunctional Electrophiles with Functionalized Aryllithium Compounds: Remarkable Chemoselectivity by Flash Chemistry

(2014) Aiichiro Nagaki et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Point-of-care biochemical assays using gold nanoparticle-implemented microfluidics

(2014) Jiashu Sun et al.   CHEMICAL SOCIETY REVIEWS

Flow approaches towards sustainability

(2014) Luigi Vaccaro et al.   GREEN CHEMISTRY

In Situ IR and X-ray High Spatial-Resolution Microspectroscopy Measurements of Multistep Organic Transformation in Flow Microreactor Catalyzed by Au Nanoclusters

(2014) Elad Gross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Research highlights: microfluidics meets big data

(2014) Peter Tseng et al.   LAB ON A CHIP

Three-dimensional flash flow microreactor for scale-up production of monodisperse PEG–PLGA nanoparticles

(2014) Kyoung-Ik Min et al.   LAB ON A CHIP

A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

(2014) Jidong Wang et al.   LAB ON A CHIP

Nanometer precise adjustment of the silver shell thickness during automated Au–Ag core–shell nanoparticle synthesis in micro fluid segment sequences

(2014) Andrea Knauer et al.   Nanoscale

Organic synthesis: The robo-chemist

(2014) Mark Peplow   NATURE

Microfluidic Synthesis of Barcode Particles for Multiplex Assays

(2014) Yuanjin Zhao et al.   Small

Controlled multistep synthesis in a three-phase droplet reactor

(2014) Adrian M. Nightingale et al.   Nature Communications

Materials for Microfluidic Chip Fabrication

(2013) Kangning Ren et al.   ACCOUNTS OF CHEMICAL RESEARCH

Microfluidic Platform for Combinatorial Synthesis and Optimization of Targeted Nanoparticles for Cancer Therapy

(2013) Pedro M. Valencia et al.   ACS Nano

Surface Patterning Using Two-Phase Laminar Flow and In Situ Formation of Aryldiazonium Salts

(2013) Andrew J. Gross et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Basic Design Concept of a Microreactor for Isothermal Operation Including Heat Conductivity

(2013) T. Fukuda et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Membrane Microreactors: Gas-Liquid Reactions Made Easy

(2013) Timothy Noël et al.   ChemSusChem

New materials for microfluidics in biology

(2013) Kangning Ren et al.   CURRENT OPINION IN BIOTECHNOLOGY

An automated Teflon microfluidic peptide synthesizer

(2013) Hui Zheng et al.   LAB ON A CHIP

Microfluidic origami: a new device format for in-line reaction monitoring by nanoelectrospray ionization mass spectrometry

(2013) Andrea E. Kirby et al.   LAB ON A CHIP

Scaled-up production of plasmonic nanoparticles using microfluidics: from metal precursors to functionalized and sterilized nanoparticles

(2013) Leyre Gomez et al.   LAB ON A CHIP

A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles

(2013) Jiashu Sun et al.   Nanoscale

A High-Output, Continuous Selective and Heterogeneous Nitration of p-Difluorobenzene

(2013) Zhiqun Yu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Microfluidics-based continuous flow formation of triangular silver nanoprisms with tuneable surface plasmon resonance

(2013) Michele Carboni et al.   Journal of Materials Chemistry C

Organic Reaction Systems: Using Microcapsules and Microreactors to Perform Chemical Synthesis

(2012) Ashley R. Longstreet et al.   ACCOUNTS OF CHEMICAL RESEARCH

Numbered-up gas–liquid micro/milli channels reactor with modular flow distributor

(2012) M. Al-Rawashdeh et al.   CHEMICAL ENGINEERING JOURNAL

Infrared imaging of temperature profiles in microreactors for fast and exothermic reactions

(2012) J. Haber et al.   CHEMICAL ENGINEERING JOURNAL

Efficient and catalyst-free condensation of acid chlorides and alcohols using continuous flow

(2012) Frederik E. A. Van Waes et al.   GREEN CHEMISTRY

Microfluidic platform for combinatorial synthesis in picolitre droplets

(2012) Ashleigh B. Theberge et al.   LAB ON A CHIP

Microfluidics for Manipulating Cells

(2012) Xuan Mu et al.   Small

Sequential Immobilization of Enzymes in Microfluidic Channels for Cascade Reactions

(2012) Sara Fornera et al.   ChemPlusChem

Kinetics research on fast exothermic reaction between cyclohexanecarboxylic acid and oleum in microreactor

(2011) K. Wang et al.   CHEMICAL ENGINEERING JOURNAL

Design and evaluation of an easily fabricated micromixer with three-dimensional periodic perturbation

(2011) Ying Lin et al.   CHEMICAL ENGINEERING JOURNAL

Microfluidic Mixing: A Review

(2011) Chia-Yen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Continuous Flow Enzyme-Catalyzed Polymerization in a Microreactor

(2011) Santanu Kundu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microfluidic Generation of Multifunctional Quantum Dot Barcode Particles

(2011) Yuanjin Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Artificial photosynthesis on a chip: microfluidic cofactor regeneration and photoenzymatic synthesis under visible light

(2011) Joon Seok Lee et al.   LAB ON A CHIP

Low Pressure Ethenolysis of Renewable Methyl Oleate in a Microchemical System

(2011) Chan Pil Park et al.   ORGANIC LETTERS

A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds

(2011) Heejin Kim et al.   Nature Communications

Nucleation and Growth of Gold Nanoparticles Studied via in situ Small Angle X-ray Scattering at Millisecond Time Resolution

(2010) Jörg Polte et al.   ACS Nano

Microfluidic Western Blot

(2010) Wenying Pan et al.   ANALYTICAL CHEMISTRY

An Integrated Microreactor System for Self-Optimization of a Heck Reaction: From Micro- to Mesoscale Flow Systems

(2010) Jonathan P. McMullen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

(2010) Fernando E. Valera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monolithic and Flexible Polyimide Film Microreactors for Organic Microchemical Applications Fabricated by Laser Ablation

(2010) Kyoung-Ik Min et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intelligent Microflow: Development of Self-Optimizing Reaction Systems

(2010) Munawwer Rasheed et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

(2010) Anastasios Polyzos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structured catalytic wall microreactor for efficient performance of exothermic reactions

(2010) Lioubov Kiwi-Minsker et al.   CHEMICAL ENGINEERING AND PROCESSING

Numbering-up and mass transfer studies of liquid–liquid two-phase microstructured reactors

(2010) M.N. Kashid et al.   CHEMICAL ENGINEERING JOURNAL

Flash Chemistry Extensively Optimized: High-Temperature Swern-Moffatt Oxidation in an Automated Microreactor Platform

(2010) Pieter J. Nieuwland et al.   Chemistry-An Asian Journal

Synthesis and Kinetics of Highly Energetic Intermediates by Micromixers: Direct Multistep Synthesis of Sodium Nitrotetrazolate

(2010) Nikolay Zaborenko et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Evolution of Catalysts Directed by Genetic Algorithms in a Plug-Based Microfluidic Device Tested with Oxidation of Methane by Oxygen

(2010) Jason E. Kreutz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Three-dimensionally crossing manifold micro-mixer for fast mixing in a short channel length

(2010) Tae Woo Lim et al.   LAB ON A CHIP

Plasmonic Nanoshell Synthesis in Microfluidic Composite Foams

(2010) Suhanya Duraiswamy et al.   NANO LETTERS

Reproducible, High-Throughput Synthesis of Colloidal Nanocrystals for Optimization in Multidimensional Parameter Space

(2010) Emory M. Chan et al.   NANO LETTERS

Aminolysis of Epoxides in a Microreactor System: A Continuous Flow Approach to β-Amino Alcohols

(2010) Matthew W. Bedore et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Thermal assisted ultrasonic bonding method for poly(methyl methacrylate) (PMMA) microfluidic devices

(2010) Zongbo Zhang et al.   TALANTA

Synthesis of Goethite by Separation of the Nucleation and Growth Processes of Ferrihydrite Nanoparticles Using Microfluidics

(2009) Ali Abou-Hassan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselectivity and the Curious Reactivity Preferences of Functional Groups

(2009) Nicholas A. Afagh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microreactor numbering-up in multi-scale networks for industrial-scale applications: Impact of flow maldistribution on the reactor performances

(2009) M. Saber et al.   CHEMICAL ENGINEERING SCIENCE

An integrated microfluidic device for large-scale in situ click chemistry screening

(2009) Yanju Wang et al.   LAB ON A CHIP

Integrated microfluidic reactors

(2009) Wei-Yu Lin et al.   Nano Today

SNOBFIT -- Stable Noisy Optimization by Branch and Fit

(2008) Waltraud Huyer et al.   ACM TRANSACTIONS ON MATHEMATICAL SOFTWARE