Journal
LAB ON A CHIP
Volume 15, Issue 3, Pages 637-641Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4lc00884g
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Funding
- NSF
- Research Investments in Science and Engineering from UC Davis
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We developed a micropatterned photodegradable hydrogel array integrated with reconfigurable microfluidics to enable cell secretion analysis and cell retrieval at the single-cell level. The activity of protease molecules secreted from single cells was monitored using FRET peptides entrapped inside microfabricated compartments. Antibody-modified gel islands tethering cells to the surface could be degraded by UV exposure to release specific single cells of interest.
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