New opportunities in drug design of metalloproteinase inhibitors: combination between structure–function experimental approaches and systems biology

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

(2010) Marie Kveiborg et al.   BIOCHEMICAL JOURNAL

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

Proteomic techniques and activity-based probes for the system-wide study of proteolysis

(2010) Ulrich auf dem Keller et al.   BIOCHIMIE

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Protective roles of matrix metalloproteinases: From mouse models to human cancer

(2010) Carlos López-Otín et al.   CELL CYCLE

A matrix metalloproteinase mediates airway remodeling in Drosophila

(2010) Bernadette M. Glasheen et al.   DEVELOPMENTAL BIOLOGY

Tumour-targeting properties of antibodies specific to MMP-1A, MMP-2 and MMP-3

(2010) Stefanie Pfaffen et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Internal Cleavages of the Autoinhibitory Prodomain Are Required for Membrane Type 1 Matrix Metalloproteinase Activation, although Furin Cleavage Alone Generates Inactive Proteinase

(2010) Vladislav S. Golubkov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Disintegrin and Metalloproteinase-10 (ADAM-10) Mediates DN30 Antibody-induced Shedding of the Met Surface Receptor

(2010) Florian Schelter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases

(2010) Matthieu Rouffet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Joy of a Career in Cell Biology

(2010) Zena Werb   MOLECULAR BIOLOGY OF THE CELL

Direct Visualization of Protease Action on Collagen Triple Helical Structure

(2010) Gabriel Rosenblum et al.   PLoS One

The metzincins - Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc-peptidases

(2010) Walter Stöcker et al.   PROTEIN SCIENCE

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

(2009) Vijaykumar M. Baragi et al.   ARTHRITIS AND RHEUMATISM

Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

(2009) Netta Sela-Passwell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Avoiding spam in the proteolytic internet: Future strategies for anti-metastatic MMP inhibition

(2009) Achim Krüger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Repeated hepatocyte growth factor neutralizing antibody treatment leads to HGF/SF unresponsiveness in human glioblastoma multiforme cells

(2009) Ping Zhao et al.   CANCER LETTERS

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Characterisation of the MMP-12-Elastin Adduct

(2009) Ivano Bertini et al.   CHEMISTRY-A EUROPEAN JOURNAL

Intra- and Interdomain Flexibility in Matrix Metalloproteinases: Functional Aspects and Drug Design

(2009) Ivano Bertini et al.   CURRENT PHARMACEUTICAL DESIGN

Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3

(2009) Stefanie Pfaffen et al.   EXPERIMENTAL CELL RESEARCH

Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants

(2009) Dorothea Piecha et al.   INFLAMMATION RESEARCH

Identification of Specific Hemopexin-like Domain Residues That Facilitate Matrix Metalloproteinase Collagenolytic Activity

(2009) Janelle L. Lauer-Fields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interdomain Flexibility in Full-length Matrix Metalloproteinase-1 (MMP-1)

(2009) Ivano Bertini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Key Sequence Determinants for the Inhibitory Function of the Prodomain of TACE†

(2008) Patricia E. Gonzales et al.   BIOCHEMISTRY

β-Hematin Interaction with the Hemopexin Domain of Gelatinase B/MMP-9 Provokes Autocatalytic Processing of the Propeptide, Thereby Priming Activation by MMP-3†

(2008) Nathalie Geurts et al.   BIOCHEMISTRY

Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells

(2008) Signe Ingvarsen et al.   BIOLOGICAL CHEMISTRY

Functional genetic mouse models: promising tools for investigation of the proteolytic internet

(2008) Achim Krüger   BIOLOGICAL CHEMISTRY

Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in bacteria

(2008) Steven R. Van Doren et al.   BIOPOLYMERS

Matrix Metalloproteinase-8 Functions as a Metastasis Suppressor through Modulation of Tumor Cell Adhesion and Invasion

(2008) A. Gutierrez-Fernandez et al.   CANCER RESEARCH

Zinc-Binding Groups Modulate Selective Inhibition of MMPs

(2008) Arpita Agrawal et al.   ChemMedChem

Structural Bases for Substrate and Inhibitor Recognition by Matrix Metalloproteinases

(2008) Loretta Aureli et al.   CURRENT MEDICINAL CHEMISTRY

Plasminogen Activator Inhibitor-2, but Not Cystatin C, Inhibits the Prometastatic Activity of Tissue Inhibitor of Metalloproteinases-1 in the Liver

(2008) Charlotte Kopitz et al.   HUMAN GENE THERAPY

MMP-12 Catalytic Domain Recognizes Triple Helical Peptide Models of Collagen V with Exosites and High Activity

(2008) Rajagopalan Bhaskaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition

(2008) Janelle L. Lauer-Fields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibody-mediated Targeting of the Urokinase-type Plasminogen Activator Proteolytic Function Neutralizes Fibrinolysisin Vivo

(2008) Ida K. Lund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quinazolinones and Pyrido[3,4-d]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis

(2008) Jie Jack Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Determinants of the ADAM Inhibition by TIMP-3: Crystal Structure of the TACE-N-TIMP-3 Complex

(2008) Magdalena Wisniewska et al.   JOURNAL OF MOLECULAR BIOLOGY

The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase B

(2008) Magda Gioia et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence of Reciprocal Reorientation of the Catalytic and Hemopexin-Like Domains of Full-Length MMP-12

(2008) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic active site-directed inhibitors of metzincins: Achievement and perspectives

(2008) A YIOTAKIS et al.   MOLECULAR ASPECTS OF MEDICINE

Protease proteomics: Revealing protease in vivo functions using systems biology approaches

(2008) A DOUCET et al.   MOLECULAR ASPECTS OF MEDICINE

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Distinct Functions of Natural ADAM-15 Cytoplasmic Domain Variants in Human Mammary Carcinoma

(2008) J. L. Zhong et al.   MOLECULAR CANCER RESEARCH

Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-α-converting enzyme

(2007) Irit Sagi et al.   ANALYTICAL BIOCHEMISTRY