Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies

Citrate Synthase Is a Novel In Vivo Matrix Metalloproteinase-9 Substrate That Regulates Mitochondrial Function in the Postmyocardial Infarction Left Ventricle

(2014) Lisandra E. de Castro Brás et al.   ANTIOXIDANTS & REDOX SIGNALING

Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site

(2014) Hiroshi Nara et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro

(2014) Timothy P. Spicer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer

(2013) R. Kaimal et al.   CANCER RESEARCH

Development of a Neutralizing Antibody Specific for the Active Form of Matrix Metalloproteinase-13

(2012) Shoichi Naito et al.   BIOCHEMISTRY

Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: A randomised controlled trial

(2012) Ronald Dahl et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds

(2011) Joshua Roth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

(2011) Diego Sbardella et al.   MOLECULAR ASPECTS OF MEDICINE

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

(2011) Netta Sela-Passwell et al.   NATURE MEDICINE

Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy: Ready for prime time?

(2010) Stanley Zucker et al.   CANCER BIOLOGY & THERAPY

Temporal and Spatial Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Following Myocardial Infarction

(2010) Merry L. Lindsey et al.   Cardiovascular Therapeutics

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

(2009) Vijaykumar M. Baragi et al.   ARTHRITIS AND RHEUMATISM

To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition

(2009) Jennifer A. Jacobsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Matrix metalloproteinase proteomics: substrates, targets, and therapy

(2009) Charlotte J Morrison et al.   CURRENT OPINION IN CELL BIOLOGY

Quinazolinones and Pyrido[3,4-d]pyrimidin-4-ones as Orally Active and Specific Matrix Metalloproteinase-13 Inhibitors for the Treatment of Osteoarthritis

(2008) Jie Jack Li et al.   JOURNAL OF MEDICINAL CHEMISTRY