The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

(2014) Ondrej Stepanek et al.   CELL

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

TCR Microclusters Pre-Exist and Contain Molecules Necessary for TCR Signal Transduction

(2014) T. J. Crites et al.   JOURNAL OF IMMUNOLOGY

Improved Ligand Discrimination by Force-Induced Unbinding of the T Cell Receptor from Peptide-MHC

(2013) Enrico Klotzsch et al.   BIOPHYSICAL JOURNAL

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system

(2013) Baoyu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Major Histocompatibility Complex (MHC) Class II-Peptide Complexes Arrive at the Plasma Membrane in Cholesterol-rich Microclusters

(2013) Berta Bosch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

(2013) S. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Determination of Interaction Kinetics between the T Cell Receptor and Peptide-Loaded MHC Class II via Single-Molecule Diffusion Measurements

(2012) Markus Axmann et al.   BIOPHYSICAL JOURNAL

Mechanical Modulation of Receptor-Ligand Interactions at Cell-Cell Interfaces

(2012) Jun F. Allard et al.   BIOPHYSICAL JOURNAL

Kinetics and Mechanics of Two-Dimensional Interactions between T Cell Receptors and Different Activating Ligands

(2012) Philippe Robert et al.   BIOPHYSICAL JOURNAL

Insights fromin situanalysis of TCR-pMHC recognition: response of an interaction network

(2012) Cheng Zhu et al.   IMMUNOLOGICAL REVIEWS

T cell triggering: insights from 2D kinetics analysis of molecular interactions

(2012) Veronika Zarnitsyna et al.   PHYSICAL BIOLOGY

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

(2011) Rashmi Kumar et al.   IMMUNITY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transforming binding affinities from three dimensions to two with application to cadherin clustering

(2011) Yinghao Wu et al.   NATURE

Pre-clustered TCR complexes

(2010) Eszter Molnár et al.   FEBS LETTERS

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increasing functional avidity of TCR-redirected T cells by removing definedN-glycosylation sites in the TCR constant domain

(2009) Jürgen Kuball et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness

(2009) A. S. Chervin et al.   JOURNAL OF IMMUNOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

(2009) Omer Dushek et al.   PLoS Computational Biology

Measuring Receptor–Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods

(2008) Wei Chen et al.   Cellular and Molecular Bioengineering

Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

(2008) Arkadiusz G. Klopocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monitoring Receptor-Ligand Interactions between Surfaces by Thermal Fluctuations

(2007) Wei Chen et al.   BIOPHYSICAL JOURNAL