T cell triggering: insights from 2D kinetics analysis of molecular interactions

The T Cell Receptor's  -Chain Connecting Peptide Motif Promotes Close Approximation of the CD8 Coreceptor Allowing Efficient Signal Initiation

(2014) M. Mallaun et al.   JOURNAL OF IMMUNOLOGY

Mechanical Modulation of Receptor-Ligand Interactions at Cell-Cell Interfaces

(2012) Jun F. Allard et al.   BIOPHYSICAL JOURNAL

Kinetics and Mechanics of Two-Dimensional Interactions between T Cell Receptors and Different Activating Ligands

(2012) Philippe Robert et al.   BIOPHYSICAL JOURNAL

Computational modeling of cellular signaling processes embedded into dynamic spatial contexts

(2012) Bastian R Angermann et al.   NATURE METHODS

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses

(2012) R. A. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

Increased Sensitivity of Antigen-Experienced T Cells through the Enrichment of Oligomeric T Cell Receptor Complexes

(2011) Rashmi Kumar et al.   IMMUNITY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physical and Functional Bivalency Observed Among TCR/CD3 Complexes Isolated from Primary T Cells

(2011) A. G. Schrum et al.   JOURNAL OF IMMUNOLOGY

Mechanical Interactions between Dendritic Cells and T Cells Correlate with T Cell Responsiveness

(2011) T. S. Lim et al.   JOURNAL OF IMMUNOLOGY

Biomimetic Engineering of Modular Bispecific Antibodies for Biomolecule Immobilization

(2011) Hideki Watanabe et al.   LANGMUIR

An Integrated Stochastic Model of “Inside-Out” Integrin Activation and Selective T-Lymphocyte Recruitment

(2011) Michael T. Beste et al.   LANGMUIR

Transforming binding affinities from three dimensions to two with application to cadherin clustering

(2011) Yinghao Wu et al.   NATURE

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

Basic residues in the T-cell receptor   cytoplasmic domain mediate membrane association and modulate signaling

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Lived, High-Strength States of ICAM-1 Bonds to β2 Integrin, I: Lifetimes of Bonds to Recombinant αLβ2 Under Force

(2010) Evan Evans et al.   BIOPHYSICAL JOURNAL

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficient stochastic simulation of reaction–diffusion processes via direct compilation

(2009) Mieszko Lis et al.   BIOINFORMATICS

Structural alterations in peptide–MHC recognition by self-reactive T cell receptors

(2009) Kai W Wucherpfennig et al.   CURRENT OPINION IN IMMUNOLOGY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: Inhibitory Effects of CD4 and CD8 on T Cell Activation Induced by High-Affinity Noncognate Ligands

(2009) A. S. Chervin et al.   JOURNAL OF IMMUNOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3 

(2009) N. Martinez-Martin et al.   Science Signaling

A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

(2009) Omer Dushek et al.   PLoS Computational Biology

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

(2008) Philippa Marrack et al.   Annual Review of Immunology

Measuring Diffusion and Binding Kinetics by Contact Area FRAP

(2008) Timothy P. Tolentino et al.   BIOPHYSICAL JOURNAL

A Coupled Diffusion-Kinetics Model for Analysis of Contact-Area FRAP Experiment

(2008) Jianhua Wu et al.   BIOPHYSICAL JOURNAL

The Safety on the TCR Trigger

(2008) Michael S. Kuhns et al.   CELL

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Measuring Receptor–Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods

(2008) Wei Chen et al.   Cellular and Molecular Bioengineering

T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales. Talking Point on the involvement of lipid rafts in T-cell activation

(2008) Hai-Tao He et al.   EMBO REPORTS

Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

(2008) Arkadiusz G. Klopocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation

(2008) Olga Yakovenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

(2008) Rémi Lasserre et al.   Nature Chemical Biology

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY

Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

(2008) Zhengyu Ma et al.   PLOS BIOLOGY

Monitoring Receptor-Ligand Interactions between Surfaces by Thermal Fluctuations

(2007) Wei Chen et al.   BIOPHYSICAL JOURNAL