Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

(2016) Luís C Santos et al.   IMMUNOLOGY AND CELL BIOLOGY

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse

(2016) Sricharan Murugesan et al.   JOURNAL OF CELL BIOLOGY

T cell activation requires force generation

(2016) Kenneth H. Hu et al.   JOURNAL OF CELL BIOLOGY

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

(2016) Sophie V. Pageon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

(2016) Catherine A Hartzell et al.   eLife

Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse

(2016) Claire Hivroz et al.   Frontiers in Immunology

Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse

(2016) William A. Comrie et al.   Frontiers in Immunology

Molecular Force Spectroscopy on Cells

(2015) Baoyu Liu et al.   Annual Review of Physical Chemistry

The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex

(2015) Baoyu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse

(2015) Bo-Ra Na et al.   JOURNAL OF CELL BIOLOGY

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Imaging the immunological synapse between dendritic cells and T cells

(2015) Kate A. Markey et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+T Cells

(2015) Jinsung Hong et al.   JOURNAL OF IMMUNOLOGY

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics

(2015) D. Li et al.   SCIENCE

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

para-Nitroblebbistatin, the Non-Cytotoxic and Photostable Myosin II Inhibitor

(2014) Miklós Képiró et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Nonmuscle Myosin II Isoforms Coassemble in Living Cells

(2014) Jordan R. Beach et al.   CURRENT BIOLOGY

Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation

(2014) Alexander Babich et al.   IMMUNOLOGICAL REVIEWS

Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells

(2014) S. Pryshchep et al.   JOURNAL OF IMMUNOLOGY

FibrilTool, an ImageJ plug-in to quantify fibrillar structures in raw microscopy images

(2014) Arezki Boudaoud et al.   Nature Protocols

CD28 and CD3 have complementary roles in T-cell traction forces

(2014) Keenan T. Bashour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force and affinity in ligand discrimination by the TCR

(2014) David Depoil et al.   TRENDS IN IMMUNOLOGY

T cell antigen receptor activation and actin cytoskeleton remodeling

(2013) Sudha Kumari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Controversy and consensus regarding myosin II function at the immunological synapse

(2013) John A Hammer et al.   CURRENT OPINION IN IMMUNOLOGY

B cell receptor-induced Ca2+ mobilization mediates F-actin rearrangements and is indispensable for adhesion and spreading of B lymphocytes

(2013) Máté Maus et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

(2012) Fang Zhao et al.   IMMUNITY

F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

(2012) Alexander Babich et al.   JOURNAL OF CELL BIOLOGY

Characterization of dynamic actin associations with T-cell receptor microclusters in primary T cells

(2012) A. A. Smoligovets et al.   JOURNAL OF CELL SCIENCE

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Integration of the movement of signaling microclusters with cellular motility in immunological synapses

(2012) Peter Beemiller et al.   NATURE IMMUNOLOGY

Myosin IIA Modulates T Cell Receptor Transport and CasL Phosphorylation during Early Immunological Synapse Formation

(2012) Yan Yu et al.   PLoS One

Affinity Thresholds for Naive CD8+ CTL Activation by Peptides and Engineered Influenza A Viruses

(2011) A. E. Denton et al.   JOURNAL OF IMMUNOLOGY

Formins filter modified actin subunits during processive elongation

(2011) Qian Chen et al.   JOURNAL OF STRUCTURAL BIOLOGY

Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

(2010) Jennifer L. Cannons et al.   IMMUNITY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Altered Actin Centripetal Retrograde Flow in Physically Restricted Immunological Synapses

(2010) Cheng-han Yu et al.   PLoS One

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell antigen receptor signaling and immunological synapse stability require myosin IIA

(2009) Tal Ilani et al.   NATURE IMMUNOLOGY

Cluster size regulates protein sorting in the immunological synapse

(2009) N. C. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor triggering by force

(2009) Zhengyu Ma et al.   TRENDS IN IMMUNOLOGY

T Cell Receptor Microcluster Transport through Molecular Mazes Reveals Mechanism of Translocation

(2008) Andrew L. DeMond et al.   BIOPHYSICAL JOURNAL

Stochastic effects and bistability in T cell receptor signaling

(2008) Tomasz Lipniacki et al.   JOURNAL OF THEORETICAL BIOLOGY

Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

(2008) Zhengyu Ma et al.   PLOS BIOLOGY