T cell activation requires force generation

Early T Cell Activation: Integrating Biochemical, Structural, and Biophysical Cues

(2015) Bernard Malissen et al.   Annual Review of Immunology

Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

(2015) Alex T. Ritter et al.   IMMUNITY

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Spatiotemporally and mechanically controlled triggering of mast cells using atomic force microscopy

(2014) Kenneth K. Hu et al.   IMMUNOLOGIC RESEARCH

Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells

(2014) S. Pryshchep et al.   JOURNAL OF IMMUNOLOGY

The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells

(2013) Francesco Marangoni et al.   IMMUNITY

Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells

(2012) P. T. Sage et al.   JOURNAL OF IMMUNOLOGY

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

(2012) Jason Yi et al.   MOLECULAR BIOLOGY OF THE CELL

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Force Measurements of TCR/pMHC Recognition at T Cell Surface

(2011) Pierre-Henri Puech et al.   PLoS One

CD4+ T-cell synapses involve multiple distinct stages

(2011) H. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

Mediation of T-Cell Activation by Actin Meshworks

(2010) P. Beemiller et al.   Cold Spring Harbor Perspectives in Biology

Microengineered Platforms for Cell Mechanobiology

(2009) Deok-Ho Kim et al.   Annual Review of Biomedical Engineering

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell antigen receptor signaling and immunological synapse stability require myosin IIA

(2009) Tal Ilani et al.   NATURE IMMUNOLOGY

Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy

(2009) B. H. Hosseini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor triggering by force

(2009) Zhengyu Ma et al.   TRENDS IN IMMUNOLOGY

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

(2008) Hao Yuan Kueh et al.   JOURNAL OF CELL BIOLOGY

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels

(2008) Christine Peinelt et al.   JOURNAL OF PHYSIOLOGY-LONDON

T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

(2008) Sarah E Henrickson et al.   NATURE IMMUNOLOGY