PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation

Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

(2017) Samina Shaheen et al.   eLife

Tapping out a mechanical code for T cell triggering

(2016) Michael L. Dustin et al.   JOURNAL OF CELL BIOLOGY

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

(2016) Katelyn M. Spillane et al.   JOURNAL OF CELL BIOLOGY

Development of nanoscale structure in LAT-based signaling complexes

(2016) Valarie A. Barr et al.   JOURNAL OF CELL SCIENCE

Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232

(2016) Liling Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defining Single Molecular Forces Required for Notch Activation Using Nano Yoyo

(2016) Farhan Chowdhury et al.   NANO LETTERS

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

Utilization of a photoactivatable antigen system to examine B-cell probing termination and the B-cell receptor sorting mechanisms during B-cell activation

(2016) Jing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Antigen Receptor Nanoclusters: Small Units with Big Functions

(2016) Wanli Liu et al.   TRENDS IN IMMUNOLOGY

Total chemical synthesis of photoactivatable proteins for light-controlled manipulation of antigen–antibody interactions

(2016) Shan Tang et al.   Chemical Science

Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D

(2016) E. Nicholas Petersen et al.   Nature Communications

Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo

(2015) Yingyue Zeng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

(2015) Mark S. Lee et al.   IMMUNITY

The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules

(2015) Liling Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor

(2015) Xiangjun Chen et al.   Nature Communications

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

(2015) Zhengpeng Wan et al.   eLife

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

(2014) Yinsheng Xu et al.   CELL RESEARCH

Regulation of EGFR nanocluster formation by ionic protein-lipid interaction

(2014) Ye Wang et al.   CELL RESEARCH

Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity

(2014) Marianne Burbage et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA-based digital tension probes reveal integrin forces during early cell adhesion

(2014) Yun Zhang et al.   Nature Communications

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

(2013) Pieta K. Mattila et al.   IMMUNITY

B Cell Activation Is Regulated by the Stiffness Properties of the Substrate Presenting the Antigens

(2013) Z. Wan et al.   JOURNAL OF IMMUNOLOGY

Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells

(2013) F. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of the B Cell Receptor Leads to Increased Membrane Proximity of the Igα Cytoplasmic Domain

(2013) Wing-Yiu Lee et al.   PLoS One

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Intrinsic Differences in the Initiation of B Cell Receptor Signaling Favor Responses of Human IgG+ Memory B Cells over IgM+ Naive B Cells

(2012) A. M. Davey et al.   JOURNAL OF IMMUNOLOGY

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

The Scaffolding Protein Synapse-Associated Protein 97 Is Required for Enhanced Signaling Through Isotype-Switched IgG Memory B Cell Receptors

(2012) W. Liu et al.   Science Signaling

The growth of B cell receptor microcluster is a universal response of B cells encountering antigens with different motion features

(2012) Zhengpeng Wan et al.   Protein & Cell

FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling

(2011) H. W. Sohn et al.   BLOOD

B Cell Receptor-Mediated Antigen Gathering Requires Ubiquitin Ligase Cbl and Adaptors Grb2 and Dok-3 to Recruit Dynein to the Signaling Microcluster

(2011) Tim Schnyder et al.   IMMUNITY

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity

(2011) Bebhinn Treanor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Essential Role for Phosphatidylinositol 4,5-Bisphosphate in the Expression, Regulation, and Gating of the Slow Afterhyperpolarization Current in the Cerebral Cortex

(2011) C. Villalobos et al.   JOURNAL OF NEUROSCIENCE

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

Intrinsic Properties of immunoglobulin IgG1 Isotype-Switched B Cell Receptors Promote Microclustering and the Initiation of Signaling

(2010) Wanli Liu et al.   IMMUNITY

PALM imaging and cluster analysis of protein heterogeneity at the cell surface

(2010) Dylan M. Owen et al.   Journal of Biophotonics

Antigen affinity discrimination is an intrinsic function of the B cell receptor

(2010) Wanli Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen-Induced Oligomerization of the B Cell Receptor Is an Early Target of FcγRIIB Inhibition

(2010) Wanli Liu et al.   JOURNAL OF IMMUNOLOGY

SYMPOSIUM REVIEW: Phosphoinositides: lipid regulators of membrane proteins

(2010) Björn H. Falkenburger et al.   JOURNAL OF PHYSIOLOGY-LONDON

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Single-Molecule Fluorescence Studies of a PH Domain: New Insights into the Membrane Docking Reaction

(2009) Jefferson D. Knight et al.   BIOPHYSICAL JOURNAL

The Constant Region of the Membrane Immunoglobulin Mediates B Cell-Receptor Clustering and Signaling in Response to Membrane Antigens

(2009) Pavel Tolar et al.   IMMUNITY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PLC-γ2 is essential for formation and maintenance of memory B cells

(2009) Masaki Hikida et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells

(2009) Niklas Engels et al.   NATURE IMMUNOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

(2008) Michele Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE