Insights fromin situanalysis of TCR-pMHC recognition: response of an interaction network

Kinetics and Mechanics of Two-Dimensional Interactions between T Cell Receptors and Different Activating Ligands

(2012) Philippe Robert et al.   BIOPHYSICAL JOURNAL

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

T cell antigen recognition at the cell membrane

(2012) Jun Huang et al.   MOLECULAR IMMUNOLOGY

T cell triggering: insights from 2D kinetics analysis of molecular interactions

(2012) Veronika Zarnitsyna et al.   PHYSICAL BIOLOGY

TCR Signaling Emerges from the Sum of Many Parts

(2012) Michael S. Kuhns et al.   Frontiers in Immunology

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

High prevalence of low affinity peptide–MHC II tetramer–negative effectors during polyclonal CD4+T cell responses

(2011) Joseph J. Sabatino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanical Interactions between Dendritic Cells and T Cells Correlate with T Cell Responsiveness

(2011) T. S. Lim et al.   JOURNAL OF IMMUNOLOGY

Transforming binding affinities from three dimensions to two with application to cadherin clustering

(2011) Yinghao Wu et al.   NATURE

Force Measurements of TCR/pMHC Recognition at T Cell Surface

(2011) Pierre-Henri Puech et al.   PLoS One

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Structural alterations in peptide–MHC recognition by self-reactive T cell receptors

(2009) Kai W Wucherpfennig et al.   CURRENT OPINION IN IMMUNOLOGY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

The molecular basis of TCR germline bias for MHC is surprisingly simple

(2009) K Christopher Garcia et al.   NATURE IMMUNOLOGY

T cell receptor triggering by force

(2009) Zhengyu Ma et al.   TRENDS IN IMMUNOLOGY

Evolutionarily Conserved Amino Acids That Control TCR-MHC Interaction

(2008) Philippa Marrack et al.   Annual Review of Immunology

Measuring Diffusion and Binding Kinetics by Contact Area FRAP

(2008) Timothy P. Tolentino et al.   BIOPHYSICAL JOURNAL

A Coupled Diffusion-Kinetics Model for Analysis of Contact-Area FRAP Experiment

(2008) Jianhua Wu et al.   BIOPHYSICAL JOURNAL

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Measuring Receptor–Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods

(2008) Wei Chen et al.   Cellular and Molecular Bioengineering

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

Replacing a Lectin Domain Residue in L-selectin Enhances Binding to P-selectin Glycoprotein Ligand-1 but Not to 6-Sulfo-sialyl Lewis x

(2008) Arkadiusz G. Klopocki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity

(2008) Zhengyu Ma et al.   PLOS BIOLOGY

Monitoring Receptor-Ligand Interactions between Surfaces by Thermal Fluctuations

(2007) Wei Chen et al.   BIOPHYSICAL JOURNAL

The receptor deformation model of TCR triggering

(2007) Zhengyu Ma et al.   FASEB JOURNAL