Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression

Peroxiredoxin-5 is a negative survival predictor in ovarian cancer

(2019) Jacek Sienko et al.   Ginekologia Polska

Essential role of JunD in cell proliferation is mediated via MYC signaling in prostate cancer cells

(2019) Bethtrice Elliott et al.   CANCER LETTERS

Peroxiredoxin Involvement in the Initiation and Progression of Human Cancer

(2018) Mark B. Hampton et al.   ANTIOXIDANTS & REDOX SIGNALING

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment

(2018) Xiaoyan Liu et al.   Future Oncology

The Comparative Biology of Mitochondrial Function and the Rate of Aging

(2018) Steven N Austad   INTEGRATIVE AND COMPARATIVE BIOLOGY

Antioxidants and Cancer: Theories, Techniques, and Trials in Preventing Cancer

(2018) Gloria M. Calaf et al.   Oxidative Medicine and Cellular Longevity

Reactive oxygen species in cancer stem cells of head and neck squamous cancer

(2018) Xu Qian et al.   SEMINARS IN CANCER BIOLOGY

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Overexpression of peroxiredoxin-3 and -5 is a potential biomarker for prognosis in endometrial cancer

(2018) Jung Byun et al.   Oncology Letters

Peroxiredoxin5 controls vertebrate ciliogenesis by modulating mitochondrial ROS

(2018) Yurim Ji et al.   ANTIOXIDANTS & REDOX SIGNALING

The prognostic values of the peroxiredoxins family in ovarian cancer

(2018) Saisai Li et al.   BIOSCIENCE REPORTS

Genome-wide identification and analysis of Nrf2 binding sites – Antioxidant response elements in zebrafish

(2018) Azhwar Raghunath et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

(2018) Patrick A. Carroll et al.   Frontiers of Medicine

Mitochondrial dynamics, a key executioner in neurodegenerative diseases

(2018) Komal Panchal et al.   MITOCHONDRION

Chemoresistance and the Self-Maintaining Tumor Microenvironment

(2018) Gulcen Yeldag et al.   Cancers

Physiological role of reactive oxygen species as promoters of natural defenses

(2017) Jérôme Roy et al.   FASEB JOURNAL

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

FOXO transcription factors at the interface of metabolism and cancer

(2017) Wolfgang Link et al.   INTERNATIONAL JOURNAL OF CANCER

Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

(2017) Hoi-Shan Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

(2017) Yang Zhao et al.   Molecular Cancer

Role of oxidative stress and antioxidants in daily nutrition and human health

(2017) Geir Bjørklund et al.   NUTRITION

Antioxidants in the Treatment of Cancer

(2017) Kanthi Athreya et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells

(2017) S Ros et al.   ONCOGENE

The Role of Redox-Regulating Enzymes in Inoperable Breast Cancers Treated with Neoadjuvant Chemotherapy

(2017) Nelli Roininen et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise

(2017) Osvaldo C. Moreira et al.   Oxidative Medicine and Cellular Longevity

Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy

(2017) Hanna-Riikka Teppo et al.   Oxidative Medicine and Cellular Longevity

The Roles of ROS in Cancer Heterogeneity and Therapy

(2017) Paulo Luiz de Sá Junior et al.   Oxidative Medicine and Cellular Longevity

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment

(2017) Violetta Krajka-Kuźniak et al.   Pharmacological Reports

Bound by Fate: The Role of Reactive Oxygen Species in Receptor-Like Kinase Signaling

(2017) Sachie Kimura et al.   PLANT CELL

Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?

(2017) Yanqing Huang et al.   Science China-Life Sciences

Mitochondrial ROS control of cancer

(2017) María del Pilar Sosa Idelchik et al.   SEMINARS IN CANCER BIOLOGY

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

(2017) David Kung-Chun Chiu et al.   Nature Communications

Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor B signaling pathway

(2017) Fang Liu et al.   Oncotarget

Peroxiredoxin 3 maintains the survival of endometrial cancer stem cells by regulating oxidative stress

(2017) In-Sung Song et al.   Oncotarget

Peroxiredoxin1, a novel regulator of pronephros development, influences retinoic acid and Wnt signaling by controlling ROS levels

(2017) Soomin Chae et al.   Scientific Reports

SIRT3: Oncogene and Tumor Suppressor in Cancer

(2017) Margalida Torrens-Mas et al.   Cancers

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

Mitochondrial dynamics during cell cycling

(2016) Rostyslav Horbay et al.   APOPTOSIS

Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections

(2016) Zhenguang Li et al.   ARCHIVES OF VIROLOGY

Crystal structures of human peroxiredoxin 6 in different oxidation states

(2016) Kyung Hee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondria, redox signaling and cell death in cancer

(2016) Simone Fulda   BIOLOGICAL CHEMISTRY

Prediction of redox-sensitive cysteines using sequential distance and other sequence-based features

(2016) Ming-an Sun et al.   BMC BIOINFORMATICS

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Expression and function of peroxiredoxins in gynecological malignancies

(2016) Xueqiong Zhu   Frontiers in Bioscience-Landmark

Association between the expression of HIF-1α and VEGF and prognostic implications in primary liver cancer

(2016) L.Y. Guo et al.   GENETICS AND MOLECULAR RESEARCH

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

(2016) Yuhui Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Silencing PRDX3 Inhibits Growth and Promotes Invasion and Extracellular Matrix Degradation in Hepatocellular Carcinoma Cells

(2016) Zhilei Liu et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative tissue proteomic investigation of invasive ductal carcinoma of breast with luminal B HER2 positive and HER2 enriched subtypes towards potential diagnostic and therapeutic biomarkers

(2016) Namita Pendharkar et al.   Journal of Proteomics

Distribution and Features of the Six Classes of Peroxiredoxins

(2016)   MOLECULES AND CELLS

Reactive Oxygen Species in Cancer Biology and Anticancer Therapy

(2016) Alexandr V. Bazhin et al.   Oxidative Medicine and Cellular Longevity

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Distinctive interrelation of p53 with SCO2, COX, and TIGAR in human gastric cancer

(2016) Sang Hyun Kim et al.   PATHOLOGY RESEARCH AND PRACTICE

Cancer stem cells and chemoresistance: The smartest survives the raid

(2016) Jihe Zhao   PHARMACOLOGY & THERAPEUTICS

Reactive oxygen species, abiotic stress and stress combination

(2016) Feroza K. Choudhury et al.   PLANT JOURNAL

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

Mitochondrial dysfunction and oxidative stress in aging and cancer

(2016) Anna V. Kudryavtseva et al.   Oncotarget

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication

(2016) Constance Qiao Xin Yeo et al.   Cell Reports

Plasma Nuclear Factor Kappa B and Serum Peroxiredoxin 3 in Early Diagnosis of Hepatocellular Carcinoma

(2015) Saber Ismail et al.   Asian Pacific Journal of Cancer Prevention

Mitochondrial ROS metabolism: 10 Years later

(2015) A. Y. Andreyev et al.   BIOCHEMISTRY-MOSCOW

Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress

(2015) Gereon Poschmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Enzymatic control of cysteinyl thiol switches in proteins

(2015) Marcel Deponte et al.   BIOLOGICAL CHEMISTRY

Reactive oxygen species in redox cancer therapy

(2015) Lingying Tong et al.   CANCER LETTERS

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

FOXO transcription factors in cancer development and therapy

(2015) Alexandra Coomans de Brachène et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondria-targeted antioxidants

(2015) Anne O. Oyewole et al.   FASEB JOURNAL

FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function

(2015) In-Sung Song et al.   GASTROENTEROLOGY

NRF2/KEAP1 and Wnt/β-catenin in the multistep process of liver carcinogenesis in humans and rats

(2015) Jean-Charles Nault et al.   HEPATOLOGY

Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production?

(2015) Eliška Holzerová et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PI3K and AKT: Unfaithful Partners in Cancer

(2015) Seraina Faes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells

(2015) Lianqin Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Circadian Oscillation of Sulfiredoxin in the Mitochondria

(2015) In Sup Kil et al.   MOLECULAR CELL

Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

(2015) WEI ZHAO et al.   Molecular Medicine Reports

Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways

(2015) Tatiana V Mishanina et al.   Nature Chemical Biology

Redox Regulation in Cancer Stem Cells

(2015) Shijie Ding et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts

(2015) Tsutomu Shimura et al.   Oncotarget

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells

(2015) Yang Cui et al.   PLoS One

Serum Peroxiredoxin3 is a Useful Biomarker for Early Diagnosis and Assessemnt of Prognosis of Hepatocellular Carcinoma in Chinese Patients

(2014) Liang Shi et al.   Asian Pacific Journal of Cancer Prevention

Mitochondrial production of reactive oxygen species

(2014) V. G. Grivennikova et al.   BIOCHEMISTRY-MOSCOW

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Mitochondrial membrane potential and reactive oxygen species in cancer stem cells

(2014) Bei-bei Zhang et al.   Familial Cancer

Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells

(2014) Hao Xi et al.   FEBS LETTERS

The antioxidant paradox: what are antioxidants and how should they be used in a therapeutic context for cancer

(2014) Michael Y Bonner et al.   Future Medicinal Chemistry

Oxidative stress markers and mitochondrial antioxidant enzyme expression are increased in aggressive Hodgkin lymphomas

(2014) Hamid Bur et al.   HISTOPATHOLOGY

Peroxiredoxin proteins protect MCF-7 breast cancer cells from doxorubicin-induced toxicity

(2014) C. McDONALD et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Peroxiredoxins as multifunctional enzymes

(2014) M. G. Sharapov et al.   MOLECULAR BIOLOGY

Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway

(2014) Pan Wang   WORLD JOURNAL OF GASTROENTEROLOGY

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

A Paradoxical Chemoresistance and Tumor Suppressive Role of Antioxidant in Solid Cancer Cells: A Strange Case of Dr. Jekyll and Mr. Hyde

(2014) Jolie Kiemlian Kwee   Biomed Research International

Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells

(2014) Brian Cunniff et al.   Redox Biology

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

Thiol–Disulfide Exchange in Signaling: Disulfide Bonds As a Switch

(2013) Joris Messens et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox-Optimized ROS Balance and the relationship between mitochondrial respiration and ROS

(2013) Sonia Cortassa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress

(2013) H C Whitaker et al.   BRITISH JOURNAL OF CANCER

Keeping mitochondria in shape: a matter of life and death

(2013) Luca Scorrano   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Antioxidants as therapies: can we improve on nature?

(2013) Michael P. Murphy   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling

(2013) I S Harris et al.   ONCOGENE

MEK in cancer and cancer therapy

(2013) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Oxidants, antioxidants and the current incurability of metastatic cancers

(2013) J. Watson   Open Biology

MiR-383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3)

(2012) Kay Ka-Wai Li et al.   BRAIN PATHOLOGY

Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation

(2012) E. V. Kalinina et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

MicroRNA-23b downregulates peroxiredoxin III in human prostate cancer

(2012) Hui-chan He et al.   FEBS LETTERS

Peroxiredoxins 3 and 4 Are Overexpressed in Prostate Cancer Tissue and Affect the Proliferation of Prostate Cancer Cells in Vitro

(2012) Ramesh Ummanni et al.   JOURNAL OF PROTEOME RESEARCH

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Single Nucleotide Polymorphisms in the PRDX3 and RPS19 and Risk of HPV Persistence and Cervical Precancer/Cancer

(2012) Mahboobeh Safaeian et al.   PLoS One

From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

(2012) T. Finkel   Science Signaling

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer

(2012) SEULHEE HAN et al.   Oncology Letters

Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

(2011) Michael P. Murphy   ANTIOXIDANTS & REDOX SIGNALING

The role of mitochondria in apoptosis

(2011) Seon-Yong Jeong et al.   BMB Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Mitochondrial Peroxiredoxin III is a Potential Target for Cancer Therapy

(2011) In-Sung Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Structure-based Insights into the Catalytic Power and Conformational Dexterity of Peroxiredoxins

(2010) Andrea Hall et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 5: Structure, Mechanism, and Function of the Mammalian Atypical 2-Cys Peroxiredoxin

(2010) Bernard Knoops et al.   ANTIOXIDANTS & REDOX SIGNALING

Interaction of p53 with Tumor Suppressive and Oncogenic Signaling Pathways to Control Cellular Reactive Oxygen Species Production

(2010) María Fátima Ladelfa et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog

(2010) Nadezhda Usmanova et al.   BIOCHIMIE

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

(2010) Katerina I. Leonova et al.   CELL CYCLE

Mitochondria in cell death

(2010) Melissa J. Parsons et al.   Essays in Biochemistry

The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells

(2010) Xiang Liu et al.   FEBS LETTERS

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells

(2010) Ahmed Abdal Dayem et al.   Cancers

The oligomeric conformation of peroxiredoxins links redox state to function

(2009) Sergio Barranco-Medina et al.   FEBS LETTERS

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1

(2008) Masaki Shiota et al.   CANCER SCIENCE

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc

(2008) J. Anthony Graves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Candidate Diagnostic Markers and Tumor Suppressor Genes for Adrenocortical Carcinoma by Expression Profile of Genes on Chromosome 11q13

(2008) Gustavo G. Fernandez-Ranvier et al.   WORLD JOURNAL OF SURGERY