Mitochondrial production of reactive oxygen species

SkQ1 treatment and food restriction — two ways to retard an aging program of organisms

(2016) Vladimir P. Skulachev   Aging-US

Partitioning of superoxide and hydrogen peroxide production by mitochondrial respiratory complex I

(2013) Vera G. Grivennikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Insight to the Interaction of the Dihydrolipoamide Acetyltransferase (E2) Core with the Peripheral Components in theEscherichia coliPyruvate Dehydrogenase Complex via Multifaceted Structural Approaches

(2013) Krishnamoorthy Chandrasekhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

The role of mitochondrial dehydrogenases in the generation of oxidative stress

(2013) Vera Adam-Vizi et al.   NEUROCHEMISTRY INTERNATIONAL

Oxygen dependent electron transfer in the cytochrome bc1 complex

(2012) Fei Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial hydrogen peroxide production as determined by the pyridine nucleotide pool and its redox state

(2012) Alexandra V. Kareyeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain

(2012) Eduardo Balsa et al.   Cell Metabolism

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

(2012) M. G. Rosca et al.   DIABETES

Hypoxia-inducible factors and their roles in energy metabolism

(2012) Nobuhito Goda et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

A Refined Analysis of Superoxide Production by Mitochondrialsn-Glycerol 3-Phosphate Dehydrogenase

(2012) Adam L. Orr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxoferryl-Porphyrin Radical Catalytic Intermediate in CytochromebdOxidases Protects Cells from Formation of Reactive Oxygen Species

(2012) Angela Paulus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergetic inhibition of the brain mitochondrial NADH: Ubiquinone oxidoreductase (Complex I) by fatty acids and Ca2+

(2011) D. S. Kalashnikov et al.   BIOCHEMISTRY-MOSCOW

X-ray structure of the dimeric cytochrome bc1 complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution

(2011) Thomas Kleinschroth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Brown adipose tissue mitochondria oxidizing fatty acids generate high levels of reactive oxygen species irrespective of the uncoupling protein-1 activity state

(2011) Peter Schönfeld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial-Targeted Plastoquinone Derivatives. Effect on Senescence and Acute Age-Related Pathologies

(2011) M. V. Skulachev et al.   CURRENT DRUG TARGETS

Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

(2011) Huali Zhang et al.   FASEB JOURNAL

Superoxide dismutases: Ancient enzymes and new insights

(2011) Anne-Frances Miller   FEBS LETTERS

Redox signaling in cardiac myocytes

(2011) Celio X.C. Santos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence for Two Sites of Superoxide Production by Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)

(2011) Jason R. Treberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of myocardial growth and death by NADPH oxidase

(2011) Yasuhiro Maejima et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells

(2011) Guy C. Brown et al.   MITOCHONDRION

Structure of the membrane domain of respiratory complex I

(2011) Rouslan G. Efremov et al.   NATURE

Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme

(2011) Crystal M. Cordes et al.   PLoS One

Functional Dissection of the Proton Pumping Modules of Mitochondrial Complex I

(2011) Stefan Dröse et al.   PLOS BIOLOGY

Discrimination between two possible reaction sequences that create potential risk of generation of deleterious radicals by cytochrome bc1

(2010) Marcin Sarewicz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

What are the sources of hydrogen peroxide production by heart mitochondria?

(2010) Vera G. Grivennikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The electron transfer flavoprotein: Ubiquinone oxidoreductases

(2010) Nicholas J. Watmough et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): The significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals

(2010) S. Tsuyoshi Ohnishi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury

(2010) Nina Kaludercic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production

(2010) Alexandra V. Kareyeva et al.   FEBS LETTERS

Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis

(2010) Numsen Hail et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reaction Mechanism of Superoxide Generation during Ubiquinol Oxidation by the Cytochromebc1Complex

(2010) Ying Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The architecture of respiratory complex I

(2010) Rouslan G. Efremov et al.   NATURE

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Modules and Structural Basis of Conformational Coupling in Mitochondrial Complex I

(2010) C. Hunte et al.   SCIENCE

Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine Oxidases

(2009) Dale E. Edmondson et al.   BIOCHEMISTRY

Site-directed mutagenesis of cytochrome c: Reactions with respiratory chain components and superoxide radical

(2009) T. Yu. Pepelina et al.   BIOCHEMISTRY-MOSCOW

Moonlighting protein in Starkeyomyces koorchalomoides: Characterization of dihydrolipoamide dehydrogenase as a protein acetyltransferase utilizing acetoxycoumarin as the acetyl group donor

(2009) Tapesh K. Tyagi et al.   BIOCHIMIE

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Direct Demonstration of Half-of-the-sites Reactivity in the Dimeric Cytochromebc1Complex

(2009) Michela Castellani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2Emission during Long-chain Fatty Acid Oxidation

(2009) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Potential Greatly Enhances Superoxide Generation by the Cytochromebc1Complex Reconstituted into Phospholipid Vesicles

(2009) Hagai Rottenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure of eukaryotic and prokaryotic complex I

(2009) T. Clason et al.   JOURNAL OF STRUCTURAL BIOLOGY

High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria

(2008) Tomáš Mráček et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Movement of the Iron−Sulfur Head Domain of Cytochromebc1Transiently Opens the Catalytic QoSite for Reaction with Oxygen†

(2008) Arkadiusz Borek et al.   BIOCHEMISTRY

Production of Reactive Oxygen Species by Complex I (NADH:Ubiquinone Oxidoreductase) from Escherichia coli and Comparison to the Enzyme from Mitochondria†

(2008) Daria Esterházy et al.   BIOCHEMISTRY

NADH/NAD+ interaction with NADH: Ubiquinone oxidoreductase (complex I)

(2008) Andrei D. Vinogradov   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The dimeric structure of the cytochrome bc1 complex prevents center P inhibition by reverse reactions at center N

(2008) Raul Covian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulatory interactions in the dimeric cytochrome bc1 complex: The advantages of being a twin

(2008) Raul Covian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Subunit mass fingerprinting of mitochondrial complex I

(2008) Nina Morgner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ammonium-dependent hydrogen peroxide production by mitochondria

(2008) Vera G. Grivennikova et al.   FEBS LETTERS

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of Mitochondrial Superoxide Production by the Cytochromebc1Complex

(2008) Stefan Dröse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism

(2008) J. I. Yeh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the role of oxygen pressure in tissue function

(2007) David F. Wilson   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

ΔΨm-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

(2003) Tatyana V. Votyakova et al.   JOURNAL OF NEUROCHEMISTRY