PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment

CD147 functions as the signaling receptor for extracellular divalent copper in hepatocellular carcinoma cells

(2017) Pengfei Ding et al.   Oncotarget

EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism

(2017) Xing-Chen Chen et al.   Oncotarget

Macrophage PI3K  Drives Pancreatic Ductal Adenocarcinoma Progression

(2016) M. M. Kaneda et al.   Cancer Discovery

Idelalisib-associated Colitis

(2015) Anna-Sophie Weidner et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Management of adverse events associated with idelalisib treatment: expert panel opinion

(2015) Steven E. Coutré et al.   LEUKEMIA & LYMPHOMA

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Increased Expression of Phosphatidylinositol 3-Kinase p110α and Gene Amplification of PIK3CA in Nasopharyngeal Carcinoma

(2015) Wai Kien Yip et al.   PATHOLOGY & ONCOLOGY RESEARCH

Formononetin Inhibits Migration and Invasion of MDA-MB-231 and 4T1 Breast Cancer Cells by Suppressing MMP-2 and MMP-9 Through PI3K/AKT Signaling Pathways

(2014) R. Zhou et al.   HORMONE AND METABOLIC RESEARCH

PIK3CA Gene Amplification and PI3K p110α Protein Expression in Breast Carcinoma

(2014) Mohammad Firoozinia et al.   International Journal of Medical Sciences

Selective Regulation of CD8 Effector T Cell Migration by the p110  Isoform of Phosphatidylinositol 3-Kinase

(2014) A. L. Martin et al.   JOURNAL OF IMMUNOLOGY

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

(2014) Khaled Ali et al.   NATURE

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

(2013) Klaus Okkenhaug   Annual Review of Immunology

PIK3R1 underexpression is an independent prognostic marker in breast cancer

(2013) Magdalena Cizkova et al.   BMC CANCER

Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer

(2013) Xiongyan Wu et al.   CANCER LETTERS

SnapShot: Class I PI3K Isoform Signaling

(2013) Ralph Fritsch et al.   CELL

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing

(2012) Pengyuan Liu et al.   CARCINOGENESIS

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

(2012) Kazuaki Yoshioka et al.   NATURE MEDICINE

PI3Kδ Is Essential for Tumor Clearance Mediated by Cytotoxic T Lymphocytes

(2012) Eva Maria Putz et al.   PLoS One

p85  phosphoinositide 3-kinase subunit regulates tumor progression

(2012) I. Cortes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking

(2011) Paul Mellor et al.   BIOCHEMICAL JOURNAL

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

(2011) Michael C. Schmid et al.   CANCER CELL

A class IA PI3K controls inflammatory cytokine production in human neutrophils

(2011) Carl F. Fortin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MHC Class II Engagement by Its Ligand LAG-3 (CD223) Contributes to Melanoma Resistance to Apoptosis

(2011) P. Hemon et al.   JOURNAL OF IMMUNOLOGY

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

(2011) A. C. Benitez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

(2011) Lydia W.T. Cheung et al.   Cancer Discovery

Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGF 1 in Melanoma Enhances Tumor Infiltration and Immunosuppression

(2010) N. Diaz-Valdes et al.   CANCER RESEARCH

The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

(2010) C. M. Taniguchi et al.   CANCER RESEARCH

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation

(2010) M. Haidinger et al.   JOURNAL OF IMMUNOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

(2009) Olga V Efimova et al.   BMC IMMUNOLOGY

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

(2009) Bijay S. Jaiswal et al.   CANCER CELL

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9

(2009) Jing-song Chen et al.   HEPATOLOGY RESEARCH

PI3K Links NKG2D Signaling to a CrkL Pathway Involved in Natural Killer Cell Adhesion, Polarity, and Granule Secretion

(2009) C. M. Segovis et al.   JOURNAL OF IMMUNOLOGY

A survey of glioblastoma genomic amplifications and deletions

(2009) Shailaja K. Rao et al.   JOURNAL OF NEURO-ONCOLOGY

Leukemic challenge unmasks a requirement for PI3K  in NK cell-mediated tumor surveillance

(2008) E. Zebedin et al.   BLOOD

Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging

(2008) C. R. Schnell et al.   CANCER RESEARCH

Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells

(2008) Regine Heller et al.   CARDIOVASCULAR RESEARCH

Phosphatidylinositol-3-Kinase-γ Is Integral to Homing Functions of Progenitor Cells

(2008) Emmanouil Chavakis et al.   CIRCULATION RESEARCH

Deletion of PI3K-p85α gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells

(2008) A Awasthi et al.   GENES AND IMMUNITY

The p110γ isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites

(2008) Molly S. Thomas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Class I PI3K in oncogenic cellular transformation

(2008) L Zhao et al.   ONCOGENE

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

(2008) T. L. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helical domain and kinase domain mutations in p110  of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

(2008) L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions

(2007) Paolo Madeddu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY