Cell matrix adhesion in cell migration

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability

(2019) Guillaume Jacquemet et al.   CURRENT BIOLOGY

Focal adhesions are essential to drive zebrafish heart valve morphogenesis

(2019) Felix Gunawan et al.   JOURNAL OF CELL BIOLOGY

Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle

(2019) Agathe Franck et al.   MOLECULAR BIOLOGY OF THE CELL

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

(2019) Maria Alieva et al.   Scientific Reports

YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility

(2019) Devon E. Mason et al.   JOURNAL OF CELL BIOLOGY

Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading

(2019) Joseph Mathew Kalappurakkal et al.   CELL

RAB6 and microtubules restrict protein secretion to focal adhesions

(2019) Lou Fourriere et al.   JOURNAL OF CELL BIOLOGY

Mutant p53 amplifies a dynamin-1/APPL1 endosome feedback loop that regulates recycling and migration

(2019) Ashley M. Lakoduk et al.   JOURNAL OF CELL BIOLOGY

Nuclear positioning facilitates amoeboid migration along the path of least resistance

(2019) Jörg Renkawitz et al.   NATURE

A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions

(2019) Nisha Bte Mohd Rafiq et al.   NATURE MATERIALS

Clathrin-containing adhesion complexes

(2019) John G. Lock et al.   JOURNAL OF CELL BIOLOGY

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intravital microscopy of collective invasion plasticity in breast cancer

(2018) Olga Ilina et al.   Disease Models & Mechanisms

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

(2018) David M. Graham et al.   JOURNAL OF CELL BIOLOGY

A systematic survey of conformational states in β1 and β4 integrins using negative-stain electron microscopy

(2018) Naoyuki Miyazaki et al.   JOURNAL OF CELL SCIENCE

Super-long single-molecule tracking reveals dynamic-anchorage-induced integrin function

(2018) Taka A. Tsunoyama et al.   Nature Chemical Biology

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

The cancer matrisome: From comprehensive characterization to biomarker discovery

(2018) Alexandra M. Socovich et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila

(2018) Hannah J Green et al.   eLife

Talin as a mechanosensitive signaling hub

(2018) Benjamin T. Goult et al.   JOURNAL OF CELL BIOLOGY

A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma

(2018) J. Matthew Barnes et al.   NATURE CELL BIOLOGY

Frustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structures

(2018) Francesco Baschieri et al.   Nature Communications

Mechanisms of integrin αVβ5 clustering in flat clathrin lattices

(2018) Alba Zuidema et al.   JOURNAL OF CELL SCIENCE

Integrin trafficking in cells and tissues

(2018) Paulina Moreno-Layseca et al.   NATURE CELL BIOLOGY

Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis

(2018) John G. Lock et al.   NATURE CELL BIOLOGY

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Talin Autoinhibition Regulates Cell-ECM Adhesion Dynamics and Wound Healing In Vivo

(2018) Amanda Haage et al.   Cell Reports

Signal transduction via integrin adhesion complexes

(2018) Jonathan D Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

FiloQuant reveals increased filopodia density during breast cancer progression

(2017) Guillaume Jacquemet et al.   JOURNAL OF CELL BIOLOGY

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors

(2017) James R.W. Conway et al.   METHODS

Force-Induced Calpain Cleavage of Talin Is Critical for Growth, Adhesion Development, and Rigidity Sensing

(2017) Mayur Saxena et al.   NANO LETTERS

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second

(2017) Nico Strohmeyer et al.   NATURE MATERIALS

ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

(2017) Alejandro E Mayorca-Guiliani et al.   NATURE MEDICINE

Atypical interactions of integrin αVβ8with pro-TGF-β1

(2017) Jianchuan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions

(2017) Vinay Swaminathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration

(2017) Nadia Elkhatib et al.   SCIENCE

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

Intermediate Filaments and the Plasma Membrane

(2017) Jonathan C.R. Jones et al.   Cold Spring Harbor Perspectives in Biology

Starved epithelial cells uptake extracellular matrix for survival

(2017) Taru Muranen et al.   Nature Communications

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

(2017) Pontus Nordenfelt et al.   Nature Communications

αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin

(2017) Mitasha Bharadwaj et al.   Nature Communications

Fibronectin-guided migration of carcinoma collectives

(2017) Sandeep Gopal et al.   Nature Communications

Shifting the optimal stiffness for cell migration

(2017) Benjamin L. Bangasser et al.   Nature Communications

Integrins as Therapeutic Targets: Successes and Cancers

(2017) Sabine Raab-Westphal et al.   Cancers

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia

(2016) Jeevisha Bajaj et al.   CANCER CELL

Multiple mechanisms of 3D migration: the origins of plasticity

(2016) Ryan J Petrie et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanosensing via cell-matrix adhesions in 3D microenvironments

(2016) Andrew D. Doyle et al.   EXPERIMENTAL CELL RESEARCH

Syndecans - key regulators of cell signaling and biological functions

(2016) Nikolaos A. Afratis et al.   FEBS Journal

Activating the nuclear piston mechanism of 3D migration in tumor cells

(2016) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

(2016) Abhishek Kumar et al.   JOURNAL OF CELL BIOLOGY

In vivoregulation of integrin turnover by outside-in activation

(2016) Pablo López-Ceballos et al.   JOURNAL OF CELL SCIENCE

The cytotoxic T lymphocyte immune synapse at a glance

(2016) Nele M. G. Dieckmann et al.   JOURNAL OF CELL SCIENCE

The glycocalyx and its significance in human medicine

(2016) J. M. Tarbell et al.   JOURNAL OF INTERNAL MEDICINE

FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly

(2016) Guilherme P. F. Nader et al.   NATURE CELL BIOLOGY

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2

(2016) Nicola De Franceschi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription

(2016) Riina Kaukonen et al.   Nature Communications

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis

(2016) Giulia Mana et al.   Nature Communications

Coordinated integrin activation by actin-dependent force during T-cell migration

(2016) Pontus Nordenfelt et al.   Nature Communications

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

(2016) M. J. Oudin et al.   Cancer Discovery

Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2

(2016) Nicola De Franceschi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion

(2016) Joseph H. R. Hetmanski et al.   PLoS Computational Biology

An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes

(2016) Hamdah Shafqat-Abbasi et al.   eLife

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

(2016) Benjamin P Bouchet et al.   eLife

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

(2015) Eishu Hirata et al.   CANCER CELL

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

Endocytic Trafficking of Integrins in Cell Migration

(2015) Nikki R. Paul et al.   CURRENT BIOLOGY

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3

(2015) Nikki R. Paul et al.   JOURNAL OF CELL BIOLOGY

Persistent cell migration and adhesion rely on retrograde transport of β1 integrin

(2015) Massiullah Shafaq-Zadah et al.   NATURE CELL BIOLOGY

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Force transmission during adhesion-independent migration

(2015) Martin Bergert et al.   NATURE CELL BIOLOGY

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

Talin determines the nanoscale architecture of focal adhesions

(2015) Jaron Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

(2015) Joseph Robertson et al.   Nature Communications

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

(2015) Adam Byron et al.   Nature Communications

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

(2015) Elena Rainero et al.   Cell Reports

F-Actin–Anchored Focal Adhesions Distinguish Endothelial Phenotypes of Human Arteries and Veins

(2014) Daphne van Geemen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrin Cytoplasmic Tail Interactions

(2014) Elizabeth M. Morse et al.   BIOCHEMISTRY

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Physical influences of the extracellular environment on cell migration

(2014) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

(2013) M. Nobis et al.   CANCER RESEARCH

Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer

(2013) P. Amornphimoltham et al.   CLINICAL CANCER RESEARCH

Role of adhesion receptor trafficking in 3D cell migration

(2013) Guillaume Jacquemet et al.   CURRENT OPINION IN CELL BIOLOGY

Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling

(2013) Mark R. Morgan et al.   DEVELOPMENTAL CELL

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex

(2013) Guillaume Jacquemet et al.   JOURNAL OF CELL BIOLOGY

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway

(2013) G. Jacquemet et al.   JOURNAL OF CELL SCIENCE

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mena binds α5 integrin directly and modulates α5β1 function

(2012) Stephanie L. Gupton et al.   JOURNAL OF CELL BIOLOGY

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

(2012) Florian Steinberg et al.   JOURNAL OF CELL BIOLOGY

Mechanical force regulates integrin turnover in Drosophila in vivo

(2012) Mary Pines et al.   NATURE CELL BIOLOGY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

Integrin Targeted Therapeutics

(2012) Melissa Millard et al.   Theranostics

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

(2011) P. Timpson et al.   CANCER RESEARCH

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)

(2010) Keefe T. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Reducing background fluorescence reveals adhesions in 3D matrices

(2010) Kristopher E. Kubow et al.   NATURE CELL BIOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices

(2010) Kathryn L. Butler et al.   PLoS One

Signal co-operation between integrins and other receptor systems

(2009) Charles H. Streuli et al.   BIOCHEMICAL JOURNAL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT

Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells

(2009) Ellen J. Ezratty et al.   JOURNAL OF CELL BIOLOGY

Linking integrin conformation to function

(2009) J. A. Askari et al.   JOURNAL OF CELL SCIENCE

Anti-integrin monoclonal antibodies

(2009) A. Byron et al.   JOURNAL OF CELL SCIENCE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Rapid leukocyte migration by integrin-independent flowing and squeezing

(2008) Tim Lämmermann et al.   NATURE