The glycocalyx and its significance in human medicine

Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases

(2015) Bernhard F. Becker et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Syndecan-1 in Acute Decompensated Heart Failure　– Association With Renal Function and Mortality –

(2015) Fernanda Macedo de Oliveira Neves et al.   CIRCULATION JOURNAL

A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3)

(2015) Xander M. van Wijk et al.   FASEB JOURNAL

Final results of a phase Ib study of gemcitabine plus PEGPH20 in patients with stage IV previously untreated pancreatic cancer.

(2015) Sunil R. Hingorani et al.   JOURNAL OF CLINICAL ONCOLOGY

Sympathoadrenal activation and endothelial damage in patients with varying degrees of acute infectious disease: An observational study

(2015) Sisse R. Ostrowski et al.   JOURNAL OF CRITICAL CARE

Dietary Supplement 4-Methylumbelliferone: An Effective Chemopreventive and Therapeutic Agent for Prostate Cancer

(2015) Travis J. Yates et al.   JNCI-Journal of the National Cancer Institute

Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients

(2015) Elaheh Rahbar et al.   Journal of Translational Medicine

Dietary Supplement 4-Methylumbelliferone: An Effective Chemopreventive and Therapeutic Agent for Prostate Cancer

(2015) Travis J. Yates et al.   JNCI-Journal of the National Cancer Institute

Modulation of CD44 Activity by A6-Peptide

(2015) Malcolm Finlayson   Frontiers in Immunology

Mechanosensing at the Vascular Interface

(2014) John M. Tarbell et al.   Annual Review of Biomedical Engineering

Damage of the endothelial glycocalyx in chronic kidney disease

(2014) Jan-Sören Padberg et al.   ATHEROSCLEROSIS

Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction

(2014) Raina Ramnath et al.   FASEB JOURNAL

MicroRNA regulation of proteoglycan function in cancer

(2014) Sherif A. Ibrahim et al.   FEBS Journal

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

(2014) Eno E. Ebong et al.   Integrative Biology

Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy

(2014) N. C. Singha et al.   MOLECULAR CANCER THERAPEUTICS

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma

(2014) Tord Hompland et al.   RADIOTHERAPY AND ONCOLOGY

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics

(2014) Edward Hammond et al.   Frontiers in Oncology

Interfering with UDP-GlcNAc Metabolism and Heparan Sulfate Expression Using a Sugar Analogue Reduces Angiogenesis

(2013) Xander M. van Wijk et al.   ACS Chemical Biology

Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding

(2013) Ye Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Endothelial Glycocalyx

(2013) Stephen R. Collins et al.   ANESTHESIA AND ANALGESIA

Fluid Mechanics, Arterial Disease, and Gene Expression

(2013) John M. Tarbell et al.   Annual Review of Fluid Mechanics

A Potential Gravity-Sensing Role of Vascular Smooth Muscle Cell Glycocalyx in Altered Gravitational Stimulation

(2013) Hongyan Kang et al.   ASTROBIOLOGY

The use of HA oligosaccharide-loaded nanoparticles to breach the endogenous hyaluronan glycocalyx for breast cancer therapy

(2013) Cuixia Yang et al.   BIOMATERIALS

Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation

(2013) Kristina M. Giantsos-Adams et al.   Cellular and Molecular Bioengineering

Sublingual Microvascular Glycocalyx Dimensions in Lacunar Stroke Patients

(2013) Remy J.H. Martens et al.   CEREBROVASCULAR DISEASES

Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion

(2013) Henry Qazi et al.   Integrative Biology

Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity

(2013) Yinghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Messengers without Borders: Mediators of Systemic Inflammatory Response in AKI

(2013) B. B. Ratliff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Alteration of the sublingual microvascular glycocalyx in critically ill patients

(2013) Abele Donati et al.   MICROVASCULAR RESEARCH

Vascular endothelium: a vulnerable transit zone for merciless sodium

(2013) H. Oberleithner   NEPHROLOGY DIALYSIS TRANSPLANTATION

Combined Anti-Inflammatory and Anti-AGE Drug Treatments Have a Protective Effect on Intervertebral Discs in Mice with Diabetes

(2013) Svenja Illien-Junger et al.   PLoS One

High Glucose Attenuates Shear-Induced Changes in Endothelial Hydraulic Conductivity by Degrading the Glycocalyx

(2013) Sandra V. Lopez-Quintero et al.   PLoS One

Mechano-sensing and transduction by endothelial surface glycocalyx: composition, structure, and function

(2013) Bingmei M. Fu et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis

(2013) Dong Ju Son et al.   Nature Communications

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

(2012) Andrew Koo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Proteoglycans in stem cells

(2012) Leyla Gasimli et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

The glycocalyx is present as soon as blood flow is initiated and is required for normal vascular development

(2012) Caitlin E. Henderson-Toth et al.   DEVELOPMENTAL BIOLOGY

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

A perivascular system releasing sirolimus prevented intimal hyperplasia in a rabbit model in a medium-term study

(2012) Ivo Skalský et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Damage of the Endothelial Glycocalyx in Dialysis Patients

(2012) C. A. Vlahu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of the Endothelial Glycocalyx Links Albuminuria and Vascular Dysfunction

(2012) A. H. J. Salmon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways

(2012) M Kesimer et al.   Mucosal Immunology

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

Nanomechanics and Sodium Permeability of Endothelial Surface Layer Modulated by Hawthorn Extract WS 1442

(2012) Wladimir Peters et al.   PLoS One

The Structural Stability of the Endothelial Glycocalyx after Enzymatic Removal of Glycosaminoglycans

(2012) Ye Zeng et al.   PLoS One

Glycocalyx Degradation Causes Microvascular Perfusion Failure in the Ex Vivo Perfused Mouse Lung

(2012) Mike Sebastian Strunden et al.   SHOCK

Vascular adhesion protein-1 and syndecan-1 in septic shock

(2011) M. SALLISALMI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Plasma Restoration of Endothelial Glycocalyx in a Rodent Model of Hemorrhagic Shock

(2011) Rosemary A. Kozar et al.   ANESTHESIA AND ANALGESIA

Fluid Flow Mechanotransduction in Vascular Smooth Muscle Cells and Fibroblasts

(2011) Zhong-Dong Shi et al.   ANNALS OF BIOMEDICAL ENGINEERING

A High Admission Syndecan-1 Level, A Marker of Endothelial Glycocalyx Degradation, Is Associated With Inflammation, Protein C Depletion, Fibrinolysis, and Increased Mortality in Trauma Patients

(2011) Pär I. Johansson et al.   ANNALS OF SURGERY

Imaging the Endothelial Glycocalyx In Vitro by Rapid Freezing/Freeze Substitution Transmission Electron Microscopy

(2011) Eno E. Ebong et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heparan sulfate proteoglycan mediates shear stress-induced endothelial gene expression in mouse embryonic stem cell-derived endothelial cells

(2011) Maria Nikmanesh et al.   BIOTECHNOLOGY AND BIOENGINEERING

Proteolytic Cleavage of the Red Blood Cell Glycocalyx in a Genetic Form of Hypertension

(2011) Cécile Pot et al.   Cellular and Molecular Bioengineering

An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes)

(2011) Sheldon Weinbaum et al.   Cellular and Molecular Bioengineering

β-d-Xylosides Stimulate GAG Synthesis in Chondrocyte Cultures Due to Elevation of the Extracellular GAG Domains, Accompanied by the Depletion of the Intra–pericellular GAG Pools, with Alterations in the GAG Profiles

(2011) Talia Weinstein et al.   CONNECTIVE TISSUE RESEARCH

Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo

(2011) Hiroshi Urakawa et al.   INTERNATIONAL JOURNAL OF CANCER

Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire ofN- andO-Glycans without Direct Incorporation

(2011) Steven R. Barthel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excessive erythrocytosis compromises the blood-endothelium interface in erythropoietin-overexpressing mice

(2011) Vincent Richter et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inhibition of Oesophageal Squamous Cell Carcinoma Progression by in vivo Targeting of Hyaluronan Synthesis

(2011) Sören Twarock et al.   Molecular Cancer

Standardized Extracts from Hawthorn Leaves and Flowers in the Treatment of Cardiovascular Disorders – Preclinical and Clinical Studies

(2011) Egon Koch et al.   PLANTA MEDICA

Heparan Sulfate Proteoglycans Mediate Interstitial Flow Mechanotransduction Regulating MMP-13 Expression and Cell Motility via FAK-ERK in 3D Collagen

(2011) Zhong-Dong Shi et al.   PLoS One

Endothelial glycocalyx and coronary vascular permeability: the fringe benefit

(2010) Bernhard F. Becker et al.   BASIC RESEARCH IN CARDIOLOGY

Study of the therapeutic benefit of cationic copolymer administration to vascular endothelium under mechanical stress

(2010) Kristina Giantsos-Adams et al.   BIOMATERIALS

Inhibition of Hyaluronan Synthesis Accelerates Murine Atherosclerosis

(2010) Nadine Nagy et al.   CIRCULATION

High glucose-mediated loss of cell surface heparan sulfate proteoglycan impairs the endothelial shear stress response

(2010) Jeremy B. Brower et al.   Cytoskeleton

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus

(2010) L. N. Broekhuizen et al.   DIABETOLOGIA

Endothelial function in individuals with coronary artery disease with and without type 2 diabetes mellitus

(2010) Gissette Reyes-Soffer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Low Molecular Weight Heparin Inhibits Experimental Metastasis in Mice Independently of the Endothelial Glycocalyx

(2010) Geerte L. Van Sluis et al.   PLoS One

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

(2010) S. Burra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan-1 shedding facilitates the resolution of neutrophilic inflammation by removing sequestered CXC chemokines

(2009) K. Hayashida et al.   BLOOD

Glycome and Transcriptome Regulation of Vasculogenesis

(2009) Rania Harfouche et al.   CIRCULATION

Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial Glycocalix

(2009) Jochen Steppan et al.   JOURNAL OF SURGICAL RESEARCH

The glycocalyx maintains a cell surface pH nanoenvironment crucial for integrin-mediated migration of human melanoma cells

(2009) Hermann Krähling et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate

(2009) Matthew J. Paszek et al.   PLoS Computational Biology

Impaired glycocalyx barrier properties contribute to enhanced intimal low-density lipoprotein accumulation at the carotid artery bifurcation in mice

(2008) Bernard M. van den Berg et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY