Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

Lmna knockout mouse embryonic fibroblasts are less contractile than their wild-type counterparts

(2017) I. A. E. W. van Loosdregt et al.   Integrative Biology

Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA

(2017) Ketan Thakar et al.   MOLECULAR BIOLOGY OF THE CELL

Shifting the optimal stiffness for cell migration

(2017) Benjamin L. Bangasser et al.   Nature Communications

Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension

(2016) Paul T. Arsenovic et al.   BIOPHYSICAL JOURNAL

Mechanotransduction and nuclear function

(2016) David M Graham et al.   CURRENT OPINION IN CELL BIOLOGY

Activating the nuclear piston mechanism of 3D migration in tumor cells

(2016) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks

(2015) Nadine R. Lang et al.   Acta Biomaterialia

Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions

(2015) Rachel M. Stewart et al.   JOURNAL OF CELL BIOLOGY

The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts

(2015) S. G. Alam et al.   JOURNAL OF CELL SCIENCE

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus

(2015) Gunes Uzer et al.   STEM CELLS

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues

(2014) Keefe T. Chan et al.   JOURNAL OF CELL BIOLOGY

Both contractile axial and lateral traction force dynamics drive amoeboid cell motility

(2014) Effie Bastounis et al.   JOURNAL OF CELL BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Cell dipole behaviour revealed by ECM sub-cellular geometry

(2014) Kalpana Mandal et al.   Nature Communications

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Arp2/3 Is Critical for Lamellipodia and Response to Extracellular Matrix Cues but Is Dispensable for Chemotaxis

(2012) Congying Wu et al.   CELL

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

Samp1 is a component of TAN lines and is required for nuclear movement

(2012) J. Borrego-Pinto et al.   JOURNAL OF CELL SCIENCE

MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function

(2012) Thomas Metzger et al.   NATURE

Thermoresponsive Micropatterned Substrates for Single Cell Studies

(2012) Kalpana Mandal et al.   PLoS One

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

(2012) Dong-Hwee Kim et al.   Scientific Reports

Orientation and function of the nuclear–centrosomal axis during cell migration

(2011) GW Gant Luxton et al.   CURRENT OPINION IN CELL BIOLOGY

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization

(2011) Christopher M. Hale et al.   JOURNAL OF CELL SCIENCE

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Actomyosin Tension Exerted on the Nucleus through Nesprin-1 Connections Influences Endothelial Cell Adhesion, Migration, and Cyclic Strain-Induced Reorientation

(2010) T.J. Chancellor et al.   BIOPHYSICAL JOURNAL

Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei

(2010) Heidi N. Fridolfsson et al.   JOURNAL OF CELL BIOLOGY

Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

(2010) E. S. Folker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Golgi polarity does not correlate with speed or persistence of freely migrating fibroblasts

(2009) Andrea C. Uetrecht et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

One-dimensional topography underlies three-dimensional fibrillar cell migration

(2009) Andrew D. Doyle et al.   JOURNAL OF CELL BIOLOGY

Myosin II Is Essential for the Spatiotemporal Organization of Traction Forces during Cell Motility

(2009) Ruedi Meili et al.   MOLECULAR BIOLOGY OF THE CELL

SUN1/2 and Syne/Nesprin-1/2 Complexes Connect Centrosome to the Nucleus during Neurogenesis and Neuronal Migration in Mice

(2009) Xiaochang Zhang et al.   NEURON

Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization

(2009) K. J. Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hard life of soft cells

(2009) Paul A. Janmey et al.   CELL MOTILITY AND THE CYTOSKELETON

Dysfunctional Connections Between the Nucleus and the Actin and Microtubule Networks in Laminopathic Models

(2008) Christopher M. Hale et al.   BIOPHYSICAL JOURNAL

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton

(2008) F. C. Nery et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE