Probiotics: If It Does Not Help It Does Not Do Any Harm. Really?

Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study

(2019) H.X. Chong et al.   Beneficial Microbes

Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota

(2018) Aïda Bafeta et al.   ANNALS OF INTERNAL MEDICINE

Gut microbiota and probiotics: novel immune system modulators in myasthenia gravis?

(2018) Elena Rinaldi et al.   Annals of the New York Academy of Sciences

Probiotic intervention influences the salivary levels of Matrix Metalloproteinase (MMP)-9 and Tissue Inhibitor of metalloproteinases (TIMP)-1 in healthy adults

(2018) Heli Jäsberg et al.   ARCHIVES OF ORAL BIOLOGY

Effect of administration of a probiotic preparation on gut microbiota and immune response in healthy women in India: an open-label, single-arm pilot study

(2018) Ankita Singh et al.   BMC GASTROENTEROLOGY

Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature

(2018) Evangelo Boumis et al.   BMC INFECTIOUS DISEASES

The long and latent road to autoimmunity

(2018) Carlo Selmi et al.   Cellular & Molecular Immunology

The microbiome in autoimmune diseases

(2018) Fabrizio De Luca et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Recent advances in probiotics as live biotherapeutics against gastrointestinal diseases

(2018) Rohini Krishna Kota et al.   CURRENT PHARMACEUTICAL DESIGN

Efficacy of probiotics on anxiety-A meta-analysis of randomized controlled trials

(2018) Bangshan Liu et al.   DEPRESSION AND ANXIETY

Antibiotic resistance, biochemical typing, and PFGE typing of Bifidobacterium strains commonly used in probiotic health foods

(2018) Feili Xu et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Impacts of microbiome metabolites on immune regulation and autoimmunity

(2018) Stefanie Haase et al.   IMMUNOLOGY

Influence of Probiotics Administration on Gut Microbiota Core

(2018) Silvia Falcinelli et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Microbial occurrence and antibiotic resistance in ready-to-go food items

(2018) Mariah L. Cole et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease

(2018) Taekil Eom et al.   JOURNAL OF MICROBIOLOGY

Anti-hypertensive peptides released from milk proteins by probiotics

(2018) Fatah B Ahtesh et al.   MATURITAS

Microbiota potential for the treatment of sexual dysfunction

(2018) Hassan Tirandaz et al.   MEDICAL HYPOTHESES

Investigation of probiotics in multiple sclerosis

(2018) Stephanie K Tankou et al.   Multiple Sclerosis Journal

The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature

(2018) Daniel J. Reis et al.   PLoS One

Systematic review and meta-analysis investigating the efficacy and safety of probiotics in people with cancer

(2018) Hadeel Hassan et al.   SUPPORTIVE CARE IN CANCER

Expanding the reach of probiotics through social enterprises

(2018) G. Reid et al.   Beneficial Microbes

The ascent of the blessed: regulatory issues on health effects and health claims for probiotics in Europe and the rest of the world

(2018) T.M.G. Dronkers et al.   Beneficial Microbes

Probiotic Species in the Modulation of Gut Microbiota: An Overview

(2018) Md. Abul Kalam Azad et al.   Biomed Research International

Investigation of probiotics in multiple sclerosis

(2018) Stephanie K Tankou et al.   Multiple Sclerosis Journal

Prophylactic probiotics for cancer therapy-induced diarrhoea

(2018) Hannah R. Wardill et al.   Current Opinion in Supportive and Palliative Care

Antibiotic Resistance Genetic Markers and Integrons in White Soft Cheese: Aspects of Clinical Resistome and Potentiality of Horizontal Gene Transfer

(2018) Ana Caroline de Paula et al.   Genes

The Present and Future of Whole Genome Sequencing (WGS) and Whole Metagenome Sequencing (WMS) for Surveillance of Antimicrobial Resistant Microorganisms and Antimicrobial Resistance Genes across the Food Chain

(2018) Elena Oniciuc et al.   Genes

Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis

(2018) Satish S. C. Rao et al.   Clinical and Translational Gastroenterology

The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials

(2018) Seyed Mohammad Aqaeinezhad Rudbane et al.   INFLAMMOPHARMACOLOGY

Antimicrobial Susceptibility Testing and Tentative Epidemiological Cutoff Values for Five Bacillus Species Relevant for Use as Animal Feed Additives or for Plant Protection

(2018) Yvonne Agersø et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

(2018) Jotham Suez et al.   CELL

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Global Survey of Antibiotic Resistance Genes in Air

(2018) Jing Li et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Probiotics in Disease Prevention and Treatment

(2018) Yuying Liu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Probiotics supplementation in children with asthma: A systematic review and meta-analysis

(2018) Jilei Lin et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Systematic review and meta-analysis of the effect of probiotic supplementation on functional constipation in children

(2018) Lei Jin et al.   MEDICINE

Effect of a Probiotic Preparation on Ventilator-Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double-Blind Randomized Controlled Trial

(2018) Ata Mahmoodpoor et al.   NUTRITION IN CLINICAL PRACTICE

Lactobacillus rhamnosus GG in the Primary Prevention of Eczema in Children: A Systematic Review and Meta-Analysis

(2018) Hania Szajewska et al.   Nutrients

A Pilot Randomized Controlled Trial to Explore Cognitive and Emotional Effects of Probiotics in Fibromyalgia

(2018) Pablo Roman et al.   Scientific Reports

Are probiotics and prebiotics effective in the prevention of travellers’ diarrhea: A systematic review and meta-analysis

(2018) Lynne V. McFarland et al.   Travel Medicine and Infectious Disease

Microbial modulation of the gut microbiome for treating autoimmune diseases

(2018) Baskar Balakrishnan et al.   Expert Review of Gastroenterology & Hepatology

The Human Gut Microbiome – A Potential Controller of Wellness and Disease

(2018) Zhi Y. Kho et al.   Frontiers in Microbiology

Fermented Foods as a Dietary Source of Live Organisms

(2018) Shannon Rezac et al.   Frontiers in Microbiology

Characterization of a Prophage-Free Derivative Strain of Lactococcus lactis ssp. lactis IL1403 Reveals the Importance of Prophages for Phenotypic Plasticity of the Host

(2018) Anne Aucouturier et al.   Frontiers in Microbiology

Brain Fogginess and SIBO: A Link or Just a Mirage?

(2018) Sanjeev Sachdeva et al.   Clinical and Translational Gastroenterology

‘Brain Fogginess’ and D-Lactic Acidosis: Probiotics Are Not the Cause

(2018) Eamonn M. M. Quigley et al.   Clinical and Translational Gastroenterology

Prokaryotic horizontal gene transfer within the human holobiont: ecological-evolutionary inferences, implications and possibilities

(2018) Ramakrishnan Sitaraman   Microbiome

Probiotics as treatment for food allergies among pediatric patients: a meta-analysis

(2018) Carol Stephanie C. Tan-Lim et al.   World Allergy Organization Journal

Identification and antibiotic susceptibility of lactobacilli isolated from turkeys

(2018) Marta Dec et al.   BMC MICROBIOLOGY

Role of the intestinal microbiome in autoimmune diseases and its use in treatments

(2018) Eric Marietta et al.   CELLULAR IMMUNOLOGY

Do probiotics, prebiotics and synbiotics affect adiponectin and leptin in adults? A systematic review and meta-analysis of clinical trials

(2018) Mohammad Hossein Rouhani et al.   CLINICAL NUTRITION

Probiotics in human health and disease: from nutribiotics to pharmabiotics

(2018) Eun-Sook Lee et al.   JOURNAL OF MICROBIOLOGY

Effect of prebiotic and probiotic supplementation on neurodevelopment in preterm very low birth weight infants: findings from a meta-analysis

(2018) Ravi Prakash Upadhyay et al.   PEDIATRIC RESEARCH

Filling the Gaps: Current Research Directions for a Rational Use of Probiotics in Preterm Infants

(2018) Arianna Aceti et al.   Nutrients

Probiotics in Autoimmune and Inflammatory Disorders

(2018) Yuying Liu et al.   Nutrients

Targeting the microbiome: from probiotics to fecal microbiota transplantation

(2018) Alexander Khoruts   Genome Medicine

Probiotics can Cause D-Lactic Acidosis and Brain Fogginess: Reply to Quigley et al.

(2018) Satish S. C. Rao et al.   Clinical and Translational Gastroenterology

Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages

(2018) Luis Vitetta et al.   Frontiers in Immunology

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity

(2018) Amy Proal et al.   Frontiers in Pediatrics

Microbial Transglutaminase Is Immunogenic and Potentially Pathogenic in Pediatric Celiac Disease

(2018) Matthias Torsten et al.   Frontiers in Pediatrics

Butyrate Producers as Potential Next-Generation Probiotics: Safety Assessment of the Administration of Butyricicoccus pullicaecorum to Healthy Volunteers

(2018) Leen Boesmans et al.   mSystems

Intestinal dysbiosis and probiotic applications in autoimmune diseases

(2017) Gislane Lelis Vilela de Oliveira et al.   IMMUNOLOGY

Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases

(2017) Beidi Chen et al.   JOURNAL OF AUTOIMMUNITY

Characterization of Antibiotic Resistance Genes fromLactobacillusIsolated from Traditional Dairy Products

(2017) Huiling Guo et al.   JOURNAL OF FOOD SCIENCE

Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials

(2017) H. Borgeraas et al.   Obesity Reviews

Prenatal and postnatal administration of prebiotics and probiotics

(2017) Kristin Sohn et al.   Seminars in Fetal & Neonatal Medicine

The human gut microbiome as source of innovation for health: Which physiological and therapeutic outcomes could we expect?

(2017) Joël Doré et al.   THERAPIE

Bacteriophages in the human gut: Our fellow travelers throughout life and potential biomarkers of heath or disease

(2017) Babak Bakhshinejad et al.   VIRUS RESEARCH

Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens

(2017) Moloko Gloria Mathipa et al.   Gut Pathogens

Microbiota and Probiotics in Health and HIV Infection

(2017) et al.   Nutrients

A review of dose-responses of probiotics in human studies

(2017) A.C. Ouwehand   Beneficial Microbes

A Functional Metagenomic Analysis of Tetracycline Resistance in Cheese Bacteria

(2017) Ana B. Flórez et al.   Frontiers in Microbiology

Prion-Like Domains in Phagobiota

(2017) George Tetz et al.   Frontiers in Microbiology

Transglutaminases in Dysbiosis As Potential Environmental Drivers of Autoimmunity

(2017) Aaron Lerner et al.   Frontiers in Microbiology

Assessing the Risk of Probiotic Dietary Supplements in the Context of Antibiotic Resistance

(2017) Min Zheng et al.   Frontiers in Microbiology

Revisiting Antibiotic Resistance Spreading in Wastewater Treatment Plants – Bacteriophages as a Much Neglected Potential Transmission Vehicle

(2017) Rolf Lood et al.   Frontiers in Microbiology

Potential Effects of Horizontal Gene Exchange in the Human Gut

(2017) Aaron Lerner et al.   Frontiers in Immunology

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

(2017) Paul W. O’Toole et al.   Nature Microbiology

Expression of prophage-encoded endolysins contributes to autolysis of Lactococcus lactis

(2016) Ganesh Ram R. Visweswaran et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The industrial food additive, microbial transglutaminase, mimics tissue transglutaminase and is immunogenic in celiac disease patients

(2016) T. Matthias et al.   AUTOIMMUNITY REVIEWS

Induction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity

(2016) Mitesh Dwivedi et al.   AUTOIMMUNITY REVIEWS

The cell aggregating propensity of probiotic actinobacterial isolates: isolation and characterization of the aggregation inducing peptide pheromone

(2016) Ramu Muthu Selvam et al.   BIOFOULING

Liver abscess and bacteremia caused by lactobacillus: role of probiotics? Case report and review of the literature

(2016) Muhammed Sherid et al.   BMC GASTROENTEROLOGY

Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters

(2016) Elisa Santocchi et al.   BMC Psychiatry

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome

(2016) María X. Maldonado-Gómez et al.   Cell Host & Microbe

The Variable Regions ofLactobacillus rhamnosusGenomes Reveal the Dynamic Evolution of Metabolic and Host-Adaptation Repertoires

(2016) Corina Ceapa et al.   Genome Biology and Evolution

Probiotic supplementation can positively affect anxiety and depressive symptoms: a systematic review of randomized controlled trials

(2016) Meysam Pirbaglou et al.   NUTRITION RESEARCH

Transkingdom control of viral infection and immunity in the mammalian intestine

(2016) J. K. Pfeiffer et al.   SCIENCE

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

(2016) Nadja B. Kristensen et al.   Genome Medicine

Addressing the Antibiotic Resistance Problem with Probiotics: Reducing the Risk of Its Double-Edged Sword Effect

(2016) Ivan C. V. J. Imperial et al.   Frontiers in Microbiology

Dysbiosis May Trigger Autoimmune Diseases via Inappropriate Post-Translational Modification of Host Proteins

(2016) Aaron Lerner et al.   Frontiers in Microbiology

Probiotics in dietary guidelines and clinical recommendations outside the European Union

(2016) Stephan Ebner et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Genomic Diversity of Phages Infecting Probiotic Strains of Lactobacillus paracasei

(2015) Diego J. Mercanti et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

(2015) Aaron Lerner et al.   AUTOIMMUNITY REVIEWS

Risk and Safety of Probiotics

(2015) Shira Doron et al.   CLINICAL INFECTIOUS DISEASES

New insights in antibiotic resistance of Lactobacillus species from fermented foods

(2015) Hikmate Abriouel et al.   FOOD RESEARCH INTERNATIONAL

Functional and Structural Characterization of the Antiphagocytic Properties of a Novel Transglutaminase fromStreptococcus suis

(2015) Jie Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Probiotics in Crohn’s Disease and in Pouchitis

(2015) Mario Guslandi   JOURNAL OF CLINICAL GASTROENTEROLOGY

Detection of antibiotic resistance in probiotics of dietary supplements

(2015) Aloysius Wong et al.   Nutrition Journal

Possible association between celiac disease and bacterial transglutaminase in food processing: a hypothesis

(2015) Aaron Lerner et al.   NUTRITION REVIEWS

Fate, activity, and impact of ingested bacteria within the human gut microbiota

(2015) Muriel Derrien et al.   TRENDS IN MICROBIOLOGY

Safety of probiotics and synbiotics in children under 18 years of age

(2015) M. van den Nieuwboer et al.   Beneficial Microbes

The history of probiotics: the untold story

(2015) M. Ozen et al.   Beneficial Microbes

The administration of probiotics and synbiotics in immune compromised adults: is it safe?

(2015) M. Van den Nieuwboer et al.   Beneficial Microbes

Effects of genetic, processing, or product formulation changes on efficacy and safety of probiotics

(2014) Mary Ellen Sanders et al.   Annals of the New York Academy of Sciences

Spontaneously Induced Prophages in Lactobacillus gasseri Contribute to Horizontal Gene Transfer

(2014) J. L. Baugher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Classification and quantification of bacteriophage taxa in human gut metagenomes

(2014) Alison S Waller et al.   ISME Journal

Yoghurt and probiotic bacteria in dietary guidelines of the member states of the European Union

(2014) L.N. Smug et al.   Beneficial Microbes

Probiotic and synbiotic safety in infants under two years of age

(2014) M. van den Nieuwboer et al.   Beneficial Microbes

Functional Screening of Antibiotic Resistance Genes from a Representative Metagenomic Library of Food Fermenting Microbiota

(2014) Chiara Devirgiliis et al.   Biomed Research International

Supra-organismal interactions in the human intestine

(2014) Laura Glendinning et al.   Frontiers in Cellular and Infection Microbiology

Antibiotic Resistance Genes in the Bacteriophage DNA Fraction of Human Fecal Samples

(2013) Pablo Quirós et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Association between funding source, methodological quality and research outcomes in randomized controlled trials of synbiotics, probiotics and prebiotics added to infant formula: A Systematic Review

(2013) Mary N Mugambi et al.   BMC Medical Research Methodology

Antimicrobial activity, antibiotic susceptibility and virulence factors of Lactic Acid Bacteria of aquatic origin intended for use as probiotics in aquaculture

(2013) Estefanía Muñoz-Atienza et al.   BMC MICROBIOLOGY

Potential impact of environmental bacteriophages in spreading antibiotic resistance genes

(2013) Maite Muniesa et al.   Future Microbiology

Role of probiotics as memory enhancer

(2013) Bikash Medhi et al.   INDIAN JOURNAL OF PHARMACOLOGY

What a Difference a Dalton Makes: Bacterial Virulence Factors Modulate Eukaryotic Host Cell Signaling Systems via Deamidation

(2013) E. J. Washington et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Antibiotic resistance in probiotic bacteria

(2013) Miguel Gueimonde et al.   Frontiers in Microbiology

Update on antibiotic resistance in foodborne Lactobacillus and Lactococcus species

(2013) Chiara Devirgiliis et al.   Frontiers in Microbiology

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

(2012) Dapeng Zhang et al.   Biology Direct

Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartment

(2012) Dapeng Zhang et al.   CELL CYCLE

Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis

(2012) Nahuel Fittipaldi et al.   Future Microbiology

Anaphylactic reaction to probiotics. Cow’s milk and hen’s egg allergens in probiotic compounds

(2012) María Flora Martín-Muñoz et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Antibiotic resistance and virulence traits in clinical and environmental Enterococcus faecalis and Enterococcus faecium isolates

(2012) I.U. Rathnayake et al.   SYSTEMATIC AND APPLIED MICROBIOLOGY

Why the European Food Safety Authority was right to reject health claims for probiotics

(2012) M.B. Katan   Beneficial Microbes

Health claim regulation of probiotics in the USA and the EU: is there a middle way?

(2012) D.E. Hoffmann   Beneficial Microbes

Immunology and probiotic impact of the newborn and young children intestinal microflora

(2011) Eugenia Bezirtzoglou et al.   ANAEROBE

Novel Probiotic Bifidobacterium longum subsp. infantis CECT 7210 Strain Active against Rotavirus Infections

(2011) José Antonio Moreno Muñoz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The last two millennias echo-catastrophes are the driving forces for the potential genetic advantage mechanisms in celiac disease

(2011) Lerner Aaron   MEDICAL HYPOTHESES

Meta-analysis: targeting the intestinal microbiota in prophylaxis for post-operative Crohn’s disease

(2010) G. A. DOHERTY et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Horizontal gene transfer amongst probiotic lactic acid bacteria and other intestinal microbiota: what are the possibilities? A review

(2010) Carol A. van Reenen et al.   ARCHIVES OF MICROBIOLOGY

Transferability of a tetracycline resistance gene from probiotic Lactobacillus reuteri to bacteria in the gastrointestinal tract of humans

(2009) Maria Egervärn et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

A case of D-lactic acid encephalopathy associated with use of probiotics

(2009) Shun Munakata et al.   BRAIN & DEVELOPMENT

Bacteriophages of Lactobacillus

(2009) Manuela Villion   Frontiers in Bioscience-Landmark

Susceptibility to tetracycline and erythromycin of Lactobacillus paracasei strains isolated from traditional Italian fermented foods

(2009) Roberta Comunian et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Identification and characterization of antibiotic resistance genes inLactobacillus reuteriandLactobacillus plantarum

(2009) M. Egervärn et al.   JOURNAL OF APPLIED MICROBIOLOGY

Probiotics for Preventive Health

(2009) Anil Minocha   NUTRITION IN CLINICAL PRACTICE

Cycle Inhibiting Factors (CIFs) Are a Growing Family of Functional Cyclomodulins Present in Invertebrate and Mammal Bacterial Pathogens

(2009) Grégory Jubelin et al.   PLoS One

Urinary D-Lactate Excretion in Infants Receiving Lactobacillus johnsonii with Formula

(2008) Elisabeth Haschke-Becher et al.   ANNALS OF NUTRITION AND METABOLISM

Removal of Antibiotic Resistance Gene-Carrying Plasmids from Lactobacillus reuteri ATCC 55730 and Characterization of the Resulting Daughter Strain, L. reuteri DSM 17938

(2008) A. Rosander et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Clinical Indications for Probiotics: An Overview

(2008) B. R. Goldin et al.   CLINICAL INFECTIOUS DISEASES

Probiotic Formulations and Applications, the Current Probiotics Market, and Changes in the Marketplace: A European Perspective

(2008) Maija Saxelin   CLINICAL INFECTIOUS DISEASES

Predictable and unpredictable evolution of antibiotic resistance

(2008) P. Courvalin   JOURNAL OF INTERNAL MEDICINE

Randomized, Double-Blind, Placebo-Controlled Trial of Probiotics for Primary Prevention: No Clinical Effects of Lactobacillus GG Supplementation

(2008) M. V. Kopp et al.   PEDIATRICS