Optical control of neuronal ion channels and receptors

Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation

(2019) Gisela Cabré et al.   Nature Communications

A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission

(2019) Qi Liu et al.   NEURON

Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses

(2019) Massimo Trusel et al.   NEURON

Locked-Azobenzene: Testing the Scope of a Unique Photoswitchable Scaffold for Cell Physiology

(2019) Ek Raj Thapaliya et al.   ACS Chemical Neuroscience

Multifunctional Fibers as Tools for Neuroscience and Neuroengineering

(2018) Andres Canales et al.   ACCOUNTS OF CHEMICAL RESEARCH

Optical Control of a Delayed Rectifier and a Two-Pore Potassium Channel with a Photoswitchable Bupivacaine

(2018) Philipp Leippe et al.   ACS Chemical Neuroscience

Optogenetic Control of Voltage-Gated Calcium Channels

(2018) Guolin Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex

(2018) John Simms et al.   BIOCHEMISTRY

Restoring Vision to the Blind with Chemical Photoswitches

(2018) Ivan Tochitsky et al.   CHEMICAL REVIEWS

In Vivo Photopharmacology

(2018) Katharina Hüll et al.   CHEMICAL REVIEWS

Design of a Highly Bistable Photoswitchable Tethered Ligand for Rapid and Sustained Manipulation of Neurotransmission

(2018) Wan-Chen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optical control of L-type Ca2+ channels using a diltiazem photoswitch

(2018) Timm Fehrentz et al.   Nature Chemical Biology

Photoactivatable drugs for nicotinic optopharmacology

(2018) Sambashiva Banala et al.   NATURE METHODS

Probing Ion Channel Structure and Function Using Light-Sensitive Amino Acids

(2018) Viktoria Klippenstein et al.   TRENDS IN BIOCHEMICAL SCIENCES

An Emerging Circuit Pharmacology of GABA A Receptors

(2018) Elif Engin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Optical functionalization of human Class A orphan G-protein-coupled receptors

(2018) Maurizio Morri et al.   Nature Communications

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand

(2018) Helen Farrants et al.   ACS Chemical Biology

Thermodynamically Stable, Photoreversible Pharmacology in Neurons with One- and Two-Photon Excitation

(2018) Stefan Passlick et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue

(2018) Stefan Passlick et al.   JOURNAL OF PHYSIOLOGY-LONDON

Restoring vision

(2018) Botond Roska et al.   NATURE

Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

(2018) Romain Durand-de Cuttoli et al.   eLife

A Light-Controlled Allosteric Modulator Unveils a Role for mGlu4 Receptors During Early Stages of Ischemia in the Rodent Cerebellar Cortex

(2018) Simon Bossi et al.   Frontiers in Cellular Neuroscience

A bright future: optogenetics to dissect the spatiotemporal control of cell behavior

(2018) Alexander G Goglia et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Photopharmacological control of bipolar cells restores visual function in blind mice

(2017) Laura Laprell et al.   JOURNAL OF CLINICAL INVESTIGATION

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

(2017) Prashant C. Donthamsetti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Near-Infrared Photoswitching of Azobenzenes under Physiological Conditions

(2017) Mingxin Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expanding and reprogramming the genetic code

(2017) Jason W. Chin   NATURE

Integration of optogenetics with complementary methodologies in systems neuroscience

(2017) Christina K. Kim et al.   NATURE REVIEWS NEUROSCIENCE

Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

(2017) Gunchul Shin et al.   NEURON

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

(2017) Daniel J. Foster et al.   NEURON

Optogenetic Control of Synaptic Composition and Function

(2017) Brooke L. Sinnen et al.   NEURON

Optogenetic Tools for Subcellular Applications in Neuroscience

(2017) Benjamin R. Rost et al.   NEURON

Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

(2017) Joshua Levitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the permeation of large organic cations through the pore of ATP-gated P2X receptors

(2017) Mahboubi Harkat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist

(2017) David M. Barber et al.   Chemical Science

Expanding the genetic code of Mus musculus

(2017) Songmi Han et al.   Nature Communications

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

(2017) Michael H. Berry et al.   Nature Communications

Restoring visual function to the blind retina with a potent, safe and long-lasting photoswitch

(2017) Ivan Tochitsky et al.   Scientific Reports

Optocontrol of glutamate receptor activity by single side-chain photoisomerization

(2017) Viktoria Klippenstein et al.   eLife

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

(2017) Joan Font et al.   eLife

Emerging Targets in Photopharmacology

(2016) Michael M. Lerch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Heritable expansion of the genetic code in mouse and zebrafish

(2016) Yuting Chen et al.   CELL RESEARCH

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

(2016) C Zussy et al.   MOLECULAR PSYCHIATRY

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

(2016) Nathan G. Hedrick et al.   NATURE

Optical inactivation of synaptic AMPA receptors erases fear memory

(2016) Kiwamu Takemoto et al.   NATURE BIOTECHNOLOGY

Genetic code expansion in the mouse brain

(2016) Russell J Ernst et al.   Nature Chemical Biology

Serotonin modulates spike probability in the axon initial segment through HCN channels

(2016) Kwang Woo Ko et al.   NATURE NEUROSCIENCE

How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina

(2016) Ivan Tochitsky et al.   NEURON

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

(2016) Joshua Levitz et al.   NEURON

Azogabazine; a photochromic antagonist of the GABAA receptor

(2016) Rosemary Huckvale et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stretchable multichannel antennas in soft wireless optoelectronic implants for optogenetics

(2016) Sung Il Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

(2016) David M. Barber et al.   Chemical Science

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

(2016) Mercè Izquierdo-Serra et al.   Nature Communications

Virus-Enabled Optimization and Delivery of the Genetic Machinery for Efficient Unnatural Amino Acid Mutagenesis in Mammalian Cells and Tissues

(2016) Yunan Zheng et al.   ACS Synthetic Biology

Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

(2016) Chloé Habermacher et al.   eLife

A family of photoswitchable NMDA receptors

(2016) Shai Berlin et al.   eLife

Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4

(2016) Christopher I Murray et al.   eLife

A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors

(2016) Joshua Levitz et al.   Frontiers in Molecular Neuroscience

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

(2016) Xavier Gómez-Santacana et al.   ACS Central Science

Allosteric regulation in NMDA receptors revealed by the genetically encoded photo-cross-linkers

(2016) Meilin Tian et al.   Scientific Reports

Red-Shifting Azobenzene Photoswitches for in Vivo Use

(2015) Mingxin Dong et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

AzoCholine Enables Optical Control of Alpha 7 Nicotinic Acetylcholine Receptors in Neural Networks

(2015) Arunas Damijonaitis et al.   ACS Chemical Neuroscience

Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist

(2015) L. Laprell et al.   ACS Chemical Neuroscience

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death

(2015) Malgorzata Borowiak et al.   CELL

Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

(2015) Jae-Woong Jeong et al.   CELL

Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential

(2015) Andreas Reiner et al.   CURRENT OPINION IN PHARMACOLOGY

An Optimized Glutamate Receptor Photoswitch with Sensitized Azobenzene Isomerization

(2015) Marta Gascón-Moya et al.   JOURNAL OF ORGANIC CHEMISTRY

In Situ Formation of an Azo Bridge on Proteins Controllable by Visible Light

(2015) Christian Hoppmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

(2015) P Li et al.   MOLECULAR PSYCHIATRY

Labelling and optical erasure of synaptic memory traces in the motor cortex

(2015) Akiko Hayashi-Takagi et al.   NATURE

An integrated microprobe for the brain

(2015) Carolina Gutierrez Herrera et al.   NATURE BIOTECHNOLOGY

Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

(2015) Sung Il Park et al.   NATURE BIOTECHNOLOGY

Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice

(2015) Kate L Montgomery et al.   NATURE METHODS

A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA A Receptors and Synaptic Inhibition

(2015) Wan-Chen Lin et al.   NEURON

Spatiotemporal Control of Opioid Signaling and Behavior

(2015) Edward R. Siuda et al.   NEURON

Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics

(2015) Elizabeth C. Carroll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of a light-gated potassium channel

(2015) C. Cosentino et al.   SCIENCE

Optodynamic simulation of β-adrenergic receptor signalling

(2015) Edward R. Siuda et al.   Nature Communications

Optical control of NMDA receptors with a diffusible photoswitch

(2015) Laura Laprell et al.   Nature Communications

Photoswitchable fatty acids enable optical control of TRPV1

(2015) James Allen Frank et al.   Nature Communications

Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool

(2015) Michiel van Wyk et al.   PLOS BIOLOGY

Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

(2015) Lian He et al.   eLife

Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand

(2015) Johannes Broichhagen et al.   ACS Central Science

Engineering a Light-Regulated GABAA Receptor for Optical Control of Neural Inhibition

(2014) Wan-Chen Lin et al.   ACS Chemical Biology

Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine

(2014) Matthias Schoenberger et al.   ACS Chemical Neuroscience

A Photochromic Agonist for μ-Opioid Receptors

(2014) Matthias Schönberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photomodulation of G Protein-Coupled Adenosine Receptors by a Novel Light-Switchable Ligand

(2014) María Isabel Bahamonde et al.   BIOCONJUGATE CHEMISTRY

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

(2014) A. Rullo et al.   CHEMICAL COMMUNICATIONS

Chemical Biology Methods for Investigating G Protein-Coupled Receptor Signaling

(2014) Thomas Huber et al.   CHEMISTRY & BIOLOGY

The in vivo chemistry of photoswitched tethered ligands

(2014) Johannes Broichhagen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Spatio-temporally precise activation of engineered receptor tyrosine kinases by light

(2014) M. Grusch et al.   EMBO JOURNAL

Caged compounds for multichromic optical interrogation of neural systems

(2014) Joseph M. Amatrudo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid

(2014) Louise Valentin-Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromophore-assisted laser inactivation - towards a spatiotemporal-functional analysis of proteins, and the ablation of chromatin, organelle and cell function

(2014) Y. Sano et al.   JOURNAL OF CELL SCIENCE

Photoinactivation of Glutamate Receptors by Genetically Encoded Unnatural Amino Acids

(2014) Viktoria Klippenstein et al.   JOURNAL OF NEUROSCIENCE

Two-Photon Neuronal and Astrocytic Stimulation with Azobenzene-Based Photoswitches

(2014) Mercè Izquierdo-Serra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration

(2014) Patrick R. O'Neill et al.   MOLECULAR BIOLOGY OF THE CELL

Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy

(2014) Andreas Reiner et al.   Nature Chemical Biology

An allosteric modulator to control endogenous G protein-coupled receptors with light

(2014) Silvia Pittolo et al.   Nature Chemical Biology

Controlling epithelial sodium channels with light using photoswitchable amilorides

(2014) Matthias Schönberger et al.   Nature Chemistry

Vertebrate Cone Opsins Enable Sustained and Highly Sensitive Rapid Control of G i/o Signaling in Anxiety Circuitry

(2014) Olivia A. Masseck et al.   NEURON

Restoring Visual Function to Blind Mice with a Photoswitch that Exploits Electrophysiological Remodeling of Retinal Ganglion Cells

(2014) Ivan Tochitsky et al.   NEURON

Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice

(2014) K. Spoida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces

(2014) S. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

(2014) Benjamin M. Gaub et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical time window for dopamine actions on the structural plasticity of dendritic spines

(2014) S. Yagishita et al.   SCIENCE

Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling

(2014) Ki-Young Chang et al.   Nature Communications

Photo-antagonism of the GABAA receptor

(2014) Martin Mortensen et al.   Nature Communications

A fully genetically encoded protein architecture for optical control of peptide ligand concentration

(2014) Daniel Schmidt et al.   Nature Communications

Optical control of insulin release using a photoswitchable sulfonylurea

(2014) Johannes Broichhagen et al.   Nature Communications

Bright Ion Channels and Lipid Bilayers

(2013) Wiktor SzymaŃski et al.   ACCOUNTS OF CHEMICAL RESEARCH

Wavelength-Selective One- and Two-Photon Uncaging of GABA

(2013) Joseph M. Amatrudo et al.   ACS Chemical Neuroscience

Two-Photon Optical Interrogation of Individual Dendritic Spines with Caged Dopamine

(2013) Roberto Araya et al.   ACS Chemical Neuroscience

Optical Control of TRPV1 Channels

(2013) Marco Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A chemist and biologist talk to each other about caged neurotransmitters

(2013) Graham CR Ellis-Davies   Beilstein Journal of Organic Chemistry

Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR

(2013) Irene Coin et al.   CELL

Design and functional evaluation of an optically active μ-opioid receptor

(2013) Philip A. Barish et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Photoaffinity Labeling of Nicotinic Receptors: Diversity of Drug Binding Sites!

(2013) Ayman K Hamouda et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Optically Selective Two-Photon Uncaging of Glutamate at 900 nm

(2013) Jeremy P. Olson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spectral Evolution of a Photochemical Protecting Group for Orthogonal Two-Color Uncaging with Visible Light

(2013) Jeremy P. Olson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Visible Light Control of an Ionotropic Glutamate Receptor

(2013) Michael A. Kienzler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoswitching Azo Compounds in Vivo with Red Light

(2013) Subhas Samanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photochemical activation of TRPA1 channels in neurons and animals

(2013) David Kokel et al.   Nature Chemical Biology

A propofol binding site on mammalian GABAA receptors identified by photolabeling

(2013) Grace M S Yip et al.   Nature Chemical Biology

GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling

(2013) Tatsuya Hayama et al.   NATURE NEUROSCIENCE

Optogenetic pharmacology for control of native neuronal signaling proteins

(2013) Richard H Kramer et al.   NATURE NEUROSCIENCE

Optical control of metabotropic glutamate receptors

(2013) Joshua Levitz et al.   NATURE NEUROSCIENCE

In Vivo Expression of a Light-Activatable Potassium Channel Using Unnatural Amino Acids

(2013) Ji-Yong Kang et al.   NEURON

Optogenetic Inhibition of Synaptic Release with Chromophore-Assisted Light Inactivation (CALI)

(2013) John Y. Lin et al.   NEURON

Optical control of trimeric P2X receptors and acid-sensing ion channels

(2013) L. E. Browne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid feedback regulation of synaptic efficacy during high-frequency activity at the Drosophila larval neuromuscular junction

(2013) G. Kauwe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical control of an ion channel gate

(2013) D. Lemoine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalization of GABAergic Inhibition by Dendritic Spines

(2013) C. Q. Chiu et al.   SCIENCE

Long-Distance Integration of Nuclear ERK Signaling Triggered by Activation of a Few Dendritic Spines

(2013) S. Zhai et al.   SCIENCE

Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

(2013) T.-i. Kim et al.   SCIENCE

Light at the end of the channel: optical manipulation of intrinsic neuronal excitability with chemical photoswitches

(2013) Alexandre Mourot et al.   Frontiers in Molecular Neuroscience

Water-Soluble, Donor-Acceptor Biphenyl Derivatives in the 2-(o-Nitrophenyl)propyl Series: Highly Efficient Two-Photon Uncaging of the Neurotransmitter γ-Aminobutyric Acid at λ=800 nm

(2012) Loïc Donato et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Azo-Propofols: Photochromic Potentiators of GABAAReceptors

(2012) Marco Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Photochromic Agonist of AMPA Receptors

(2012) Philipp Stawski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bidirectional Photocontrol of Peptide Conformation with a Bridged Azobenzene Derivative

(2012) Subhas Samanta et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition

(2012) Damien Lemoine et al.   CHEMICAL REVIEWS

Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release

(2012) Dongdong Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors

(2012) Ivan Tochitsky et al.   Nature Chemistry

Rapid optical control of nociception with an ion-channel photoswitch

(2012) Alexandre Mourot et al.   NATURE METHODS

Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons

(2012) David M Dietz et al.   NATURE NEUROSCIENCE

Photoactivatable Neuropeptides for Spatiotemporally Precise Delivery of Opioids in Neural Tissue

(2012) Matthew R. Banghart et al.   NEURON

Optical Control of Endogenous Proteins with a Photoswitchable Conditional Subunit Reveals a Role for TREK1 in GABAB Signaling

(2012) Guillaume Sandoz et al.   NEURON

Photochemical Restoration of Visual Responses in Blind Mice

(2012) Aleksandra Polosukhina et al.   NEURON

New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups

(2012) Francisco Palma-Cerda et al.   NEUROPHARMACOLOGY

Synaptic Neurotransmitter-Gated Receptors

(2012) T. G. Smart et al.   Cold Spring Harbor Perspectives in Biology

Robust photoregulation of GABAA receptors by allosteric modulation with a propofol analogue

(2012) Lan Yue et al.   Nature Communications

Tuning Photochromic Ion Channel Blockers

(2011) Alexandre Mourot et al.   ACS Chemical Neuroscience

Azobenzene photoswitches for biomolecules

(2011) Andrew A. Beharry et al.   CHEMICAL SOCIETY REVIEWS

Optogenetic photochemical control of designer K+ channels in mammalian neurons

(2011) Doris L. Fortin et al.   JOURNAL OF NEUROPHYSIOLOGY

In vivotwo-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice

(2011) Jun Noguchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

LiGluR Restores Visual Responses in Rodent Models of Inherited Blindness

(2011) Natalia Caporale et al.   MOLECULAR THERAPY

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

(2011) Hideji Murakoshi et al.   NATURE

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Two-photon uncaging: New prospects in neuroscience and cellular biology

(2010) D. Warther et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Substitution of 5-HT1AReceptor Signaling by a Light-activated G Protein-coupled Receptor

(2010) Eugene Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two-photon uncaging of γ-aminobutyric acid in intact brain tissue

(2010) Masanori Matsuzaki et al.   Nature Chemical Biology

A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing

(2010) Harald Janovjak et al.   NATURE NEUROSCIENCE

Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits

(2010) Yusuf Tufail et al.   NEURON

AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation

(2010) M. A. Patterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Discrimination of Temporal Input Sequences in Cortical Neurons

(2010) T. Branco et al.   SCIENCE

Photochromic Blockers of Voltage-Gated Potassium Channels

(2009) Matthew���R. Banghart et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Electrophysiology in the age of light

(2009) Massimo Scanziani et al.   NATURE

Activation of CaMKII in single dendritic spines during long-term potentiation

(2009) Seok-Jin R. Lee et al.   NATURE

Optogenetic dissection of a behavioural module in the vertebrate spinal cord

(2009) Claire Wyart et al.   NATURE

Two-color, two-photon uncaging of glutamate and GABA

(2009) Srinivas Kantevari et al.   NATURE METHODS

Photochemical control of endogenous ion channels and cellular excitability

(2008) Doris L Fortin et al.   NATURE METHODS

Optical induction of plasticity at single synapses reveals input-specific accumulation of  CaMKII

(2008) Y.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine

(2008) C. D. Harvey et al.   SCIENCE

Photorelease of GABA with visible light using an inorganic caging group

(2008) Emiliano M. Rial Verde   Frontiers in Neural Circuits