Emerging Targets in Photopharmacology

Photoswitchable anticancer activity via trans–cis isomerization of a combretastatin A-4 analog

(2016) Jonathon E. Sheldon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Red-Shifting Azobenzene Photoswitches for in Vivo Use

(2015) Mingxin Dong et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist

(2015) L. Laprell et al.   ACS Chemical Neuroscience

Optical Control of Insulin Secretion Using an Incretin Switch

(2015) Johannes Broichhagen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Activated Molecular Switches

(2015) David Bléger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ciprofloxacin–Photoswitch Conjugates: A Facile Strategy for Photopharmacology

(2015) Willem A. Velema et al.   BIOCONJUGATE CHEMISTRY

Mesoscopic and Macroscopic Optoacoustic Imaging of Cancer

(2015) A. Taruttis et al.   CANCER RESEARCH

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death

(2015) Malgorzata Borowiak et al.   CELL

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

(2015) J. Broichhagen et al.   CHEMICAL COMMUNICATIONS

Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy

(2015) Wiktor Szymanski et al.   CHEMISTRY-A EUROPEAN JOURNAL

Current Status of Photodynamic Therapy in Digestive Tract Carcinoma in Japan

(2015) Atsushi Nanashima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Photoreceptor Ablation Initiates the Immediate Loss of Glutamate Receptors in Postsynaptic Bipolar Cells in Retina

(2015) F. A. Dunn   JOURNAL OF NEUROSCIENCE

Molecular Fluorescence Endoscopy Targeting Vascular Endothelial Growth Factor A for Improved Colorectal Polyp Detection

(2015) J. J. Tjalma et al.   JOURNAL OF NUCLEAR MEDICINE

Multiple myeloma

(2015) Christoph Röllig et al.   LANCET

High-throughput optical sensing of nucleic acids in a nanopore array

(2015) Shuo Huang et al.   Nature Nanotechnology

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein–protein binding

(2015) Christoffer Karlsson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis, Characterization, and Bioactivity of the Photoisomerizable Tubulin Polymerization Inhibitor azo-Combretastatin A4

(2015) Ashton J. Engdahl et al.   ORGANIC LETTERS

Photodynamic therapy (PDT) for malignant brain tumors – Where do we stand?

(2015) Brendan J. Quirk et al.   Photodiagnosis and Photodynamic Therapy

Spotlighted Brains: Optogenetic Activation and Silencing of Neurons

(2015) Arash Kianianmomeni et al.   TRENDS IN BIOCHEMICAL SCIENCES

Photoswitchable fatty acids enable optical control of TRPV1

(2015) James Allen Frank et al.   Nature Communications

Design, Synthesis and Inhibitory Activity of Photoswitchable RET Kinase Inhibitors

(2015) Rubén Ferreira et al.   Scientific Reports

Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine

(2014) Matthias Schoenberger et al.   ACS Chemical Neuroscience

Acetylcholinesterase Inhibitors with Photoswitchable Inhibition of β-Amyloid Aggregation

(2014) Xinyu Chen et al.   ACS Chemical Neuroscience

Controlling Biological Activity with Light: Diarylethene-Containing Cyclic Peptidomimetics

(2014) Oleg Babii et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Photochromic Agonist for μ-Opioid Receptors

(2014) Matthias Schönberger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Saxitoxin

(2014) Arun P. Thottumkara et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optical Control of Acetylcholinesterase with a Tacrine Switch

(2014) Johannes Broichhagen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteasome Inhibitors with Photocontrolled Activity

(2014) Mickel J. Hansen et al.   CHEMBIOCHEM

Nanopore Sequencing: From Imagination to Reality

(2014) H. Bayley   CLINICAL CHEMISTRY

The in vivo chemistry of photoswitched tethered ligands

(2014) Johannes Broichhagen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging

(2014) Livia S. Eberlin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photopharmacology: Beyond Proof of Principle

(2014) Willem A. Velema et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An allosteric modulator to control endogenous G protein-coupled receptors with light

(2014) Silvia Pittolo et al.   Nature Chemical Biology

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts

(2014) Brian J Wainger et al.   NATURE NEUROSCIENCE

Restoring Visual Function to Blind Mice with a Photoswitch that Exploits Electrophysiological Remodeling of Retinal Ganglion Cells

(2014) Ivan Tochitsky et al.   NEURON

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

(2014) C. Falenczyk et al.   Chemical Science

Optical control of insulin release using a photoswitchable sulfonylurea

(2014) Johannes Broichhagen et al.   Nature Communications

Bright Ion Channels and Lipid Bilayers

(2013) Wiktor SzymaŃski et al.   ACCOUNTS OF CHEMICAL RESEARCH

Optical Control of TRPV1 Channels

(2013) Marco Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoswitching ofortho-Substituted Azonium Ions by Red Light in Whole Blood

(2013) Subhas Samanta et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors

(2013) Bernd Reisinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches

(2013) Wiktor Szymański et al.   CHEMICAL REVIEWS

Photochemical activation of TRPA1 channels in neurons and animals

(2013) David Kokel et al.   Nature Chemical Biology

A light switch for pain

(2013) Otto Fajardo et al.   Nature Chemical Biology

Optical control of antibacterial activity

(2013) Willem A. Velema et al.   Nature Chemistry

Multistep protein unfolding during nanopore translocation

(2013) David Rodriguez-Larrea et al.   Nature Nanotechnology

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Photoactivatable metal complexes: from theory to applications in biotechnology and medicine

(2013) N. A. Smith et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate

(2013) L. Harrington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Azo-Propofols: Photochromic Potentiators of GABAAReceptors

(2012) Marco Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Light-Controlled Tools

(2012) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers

(2012) Timm Fehrentz et al.   CHEMBIOCHEM

Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition

(2012) Damien Lemoine et al.   CHEMICAL REVIEWS

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

o-Fluoroazobenzenes as Readily Synthesized Photoswitches Offering Nearly Quantitative Two-Way Isomerization with Visible Light

(2012) David Bléger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reversible Low-Light Induced Photoswitching of Crowned Spiropyran-DO3A Complexed with Gadolinium(III) Ions

(2012) Klaus Kruttwig et al.   MOLECULES

Rapid optical control of nociception with an ion-channel photoswitch

(2012) Alexandre Mourot et al.   NATURE METHODS

Photochemical Restoration of Visual Responses in Blind Mice

(2012) Aleksandra Polosukhina et al.   NEURON

Photodynamic therapy in urology: What can we do now and where are we heading?

(2012) G. Bozzini et al.   Photodiagnosis and Photodynamic Therapy

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuning Photochromic Ion Channel Blockers

(2011) Alexandre Mourot et al.   ACS Chemical Neuroscience

Optochemical Genetics

(2011) Timm Fehrentz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

TRPV1 and TRPA1 channels in inflammatory pain: elucidating mechanisms

(2011) Susan D. Brain   Annals of the New York Academy of Sciences

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Theranostics: Combining Imaging and Therapy

(2011) Sneha S. Kelkar et al.   BIOCONJUGATE CHEMISTRY

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events

(2011) S. Arastu-Kapur et al.   CLINICAL CANCER RESEARCH

p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol

(2011) Deirdre S. Stewart et al.   JOURNAL OF MEDICINAL CHEMISTRY

Society's failure to protect a precious resource: antibiotics

(2011) Jean Carlet et al.   LANCET

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Tuberculosis

(2011) Stephen D Lawn et al.   LANCET

LiGluR Restores Visual Responses in Rodent Models of Inherited Blindness

(2011) Natalia Caporale et al.   MOLECULAR THERAPY

Bisubstrate specificity in histidine/tryptophan biosynthesis isomerase fromMycobacterium tuberculosisby active site metamorphosis

(2011) Anne V. Due et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions of AChE with A? Aggregates in Alzheimer?s Brain: Therapeutic Relevance of IDN 5706

(2011) Francisco J. Carvajal et al.   Frontiers in Molecular Neuroscience

Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid

(2011) María-Salud García-Ayllón   Frontiers in Molecular Neuroscience

Ocular Drug Delivery

(2010) Ripal Gaudana et al.   AAPS Journal

Light-Induced Control of Protein Translocation by the SecYEG Complex

(2010) Francesco Bonardi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tacrine Derivatives and Alzheimers Disease

(2010) V. Tumiatti et al.   CURRENT MEDICINAL CHEMISTRY

Recent advances in the prevention and treatment of skin cancer using photodynamic therapy

(2010) Baozhong Zhao et al.   Expert Review of Anticancer Therapy

Structured illumination enhances resolution and contrast in thick tissue fluorescence imaging

(2010) Amaan Mazhar et al.   JOURNAL OF BIOMEDICAL OPTICS

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family

(2010) L.-J. Wu et al.   PHARMACOLOGICAL REVIEWS

Photochromic Blockers of Voltage-Gated Potassium Channels

(2009) Matthew���R. Banghart et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

New photochemical tools for controlling neuronal activity

(2009) Richard H Kramer et al.   CURRENT OPINION IN NEUROBIOLOGY

Functional remodeling of glutamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration

(2009) Jacqueline Chua et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Phase II Trial of Fosbretabulin in Advanced Anaplastic Thyroid Carcinoma and Correlation of Baseline Serum-Soluble Intracellular Adhesion Molecule-1 with Outcome

(2009) Colin J. Mooney et al.   THYROID

Photodynamic Therapy: Standard of Care for Palliation of Cholangiocarcinoma?

(2008) Todd H. Baron   Clinical Gastroenterology and Hepatology

Photodynamic therapy of cervical intraepithelial neoplasia with hexaminolevulinate

(2008) Philipp Soergel et al.   LASERS IN SURGERY AND MEDICINE

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Antibiotics and Antibiotic Resistance Genes in Natural Environments

(2008) J. L. Martinez   SCIENCE

SAR studies of capsazepinoid bronchodilators 3: The thiourea part (coupling region) and the 2-(4-chlorophenyl)ethyl moiety (C-region)

(2007) Magnus Berglund et al.   BIOORGANIC & MEDICINAL CHEMISTRY