Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

(2019) Suvi Annala et al.   Science Signaling

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

(2019) Xiaodong Feng et al.   CANCER CELL

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP

(2018) Qi Hu et al.   CELL

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

GPCRs: Emerging anti-cancer drug targets

(2018) Ainhoa Nieto Gutierrez et al.   CELLULAR SIGNALLING

Blockade of CCR5-mediated myeloid derived suppressor cell accumulation enhances anti-PD1 efficacy in gastric cancer

(2018) Liu Yang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)

(2018) Richard D. Carvajal et al.   JOURNAL OF CLINICAL ONCOLOGY

Next generation of immune checkpoint therapy in cancer: new developments and challenges

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

(2018) Krushna C. Patra et al.   NATURE CELL BIOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Arrestins as rheostats of GPCR signalling

(2018) J. Silvio Gutkind et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets

(2018) Paul A. Insel et al.   Frontiers in Pharmacology

Role of Dopamine Receptors in the Anticancer Activity of ONC201

(2018) Christina Leah B. Kline et al.   NEOPLASIA

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

(2018) Kyle Ellrott et al.   Cell Systems

Propranolol for Off-label Treatment of Patients With Melanoma

(2018) Vincenzo De Giorgi et al.   JAMA Oncology

GNAS, GNAQ, and GNA11 Alterations in Patients With Diverse Cancers

(2018) Austin J. Parish et al.   CANCER

Structural insights into G-protein-coupled receptor allostery

(2018) David M. Thal et al.   NATURE

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

(2018) Michael D. Onken et al.   Science Signaling

Frizzleds as GPCRs – More Conventional Than We Thought!

(2018) Gunnar Schulte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling

(2018) Noboru Ideno et al.   GASTROENTEROLOGY

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

(2018) Dominic Lapadula et al.   MOLECULAR CANCER RESEARCH

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers

(2017) Suhail Ahmed Kabeer Rasheed et al.   ONCOGENE

Cancer and nerves: A tuf(t) partnership

(2017) Paula A. Kiberstis   SCIENCE

Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers

(2017) Monique B. Nilsson et al.   Science Translational Medicine

Activation of PGE2/EP2 and PGE2/EP4 signaling pathways positively regulate the level of PD‑1 in infiltrating CD8+ T cells in patients with lung cancer

(2017) Jinhong Wang et al.   Oncology Letters

A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma

(2017) Isabel Arrillaga-Romany et al.   Oncotarget

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

(2017) Grace R. Anderson et al.   Cell Reports

Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma

(2016) Ugur M. Ayturk et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hijacking GPCRs by viral pathogens and tumor

(2016) Junjie Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hedgehog signalling

(2016) Raymond Teck Ho Lee et al.   DEVELOPMENT

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

(2016) Amanda R Moore et al.   NATURE GENETICS

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

(2016) Maicol Mancini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

(2016) A Maiga et al.   Blood Cancer Journal

GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth

(2016) N S Bayin et al.   Oncogenesis

Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status

(2016) Naitao Wang et al.   Stem Cell Reports

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Akio Ohta   Frontiers in Immunology

Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities

(2015) Pranav Mathur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt

(2015) N. Wang et al.   CLINICAL CANCER RESEARCH

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells

(2015) M O'Hayre et al.   ONCOGENE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

GNA13 as a prognostic factor and mediator of gastric cancer progression

(2015) Jia-Xing Zhang et al.   Oncotarget

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

(2015) Robert D. Leone et al.   Computational and Structural Biotechnology Journal

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Novel insights into G protein and G protein-coupled receptor signaling in cancer

(2014) Morgan O’Hayre et al.   CURRENT OPINION IN CELL BIOLOGY

GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type

(2014) Ryosuke Nomura et al.   HUMAN PATHOLOGY

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance

(2014) Akinori Yoda et al.   NATURE MEDICINE

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin

(2014) Hakan Alakus et al.   Genome Medicine

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

(2014) Glenn S Cowley et al.   Scientific Data

Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors

(2013) Stefan Offermanns   Annual Review of Pharmacology and Toxicology

G13 Controls Angiogenesis through Regulation of VEGFR-2 Expression

(2013) Kishor Kumar Sivaraj et al.   DEVELOPMENTAL CELL

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

(2013) Cory M. Johannessen et al.   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ

(2013) Matthew D. Shirley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy

(2013) Christel Devaud et al.   OncoImmunology

Protease-activated receptor-2 (PAR2) mediates VEGF production through the ERK1/2 pathway in human glioblastoma cell lines

(2012) Angélica Dutra-Oliveira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and characterization of alternative exon usage linked glioblastoma multiforme survival

(2012) Ahmed Sadeque et al.   BMC Medical Genomics

Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis

(2012) M. Nagahashi et al.   CANCER RESEARCH

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Tumor-Infiltrating Monocytic Myeloid-Derived Suppressor Cells Mediate CCR5-Dependent Recruitment of Regulatory T Cells Favoring Tumor Growth

(2012) E. Schlecker et al.   JOURNAL OF IMMUNOLOGY

A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors

(2012) Jose P. Vaqué et al.   MOLECULAR CELL

The genetic landscape of mutations in Burkitt lymphoma

(2012) Cassandra Love et al.   NATURE GENETICS

Activation of Protease-Activated Receptor 2 Induces VEGF Independently of HIF-1

(2012) Jeppe Grøndahl Rasmussen et al.   PLoS One

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

(2012) J. G. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compensatory Pathways in Oncogenic Kinase Signaling and Resistance to Targeted Therapies: Six Degrees of Separation: Figure 1.

(2012) Livio Trusolino et al.   Cancer Discovery

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Key role of the positive feedback between PGE2and COX2 in the biology of myeloid-derived suppressor cells

(2012) Nataša Obermajer et al.   OncoImmunology

Molecular Mechanisms Deployed by Virally Encoded G Protein–Coupled Receptors in Human Diseases

(2011) Silvia Montaner et al.   Annual Review of Pharmacology and Toxicology

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer

(2011) Cecilia L. Speyer et al.   BREAST CANCER RESEARCH AND TREATMENT

PI3Kγ Mediates Kaposi's Sarcoma-Associated Herpesvirus vGPCR-Induced Sarcomagenesis

(2011) Daniel Martin et al.   CANCER CELL

Coxibs and Other Nonsteroidal Anti-Inflammatory Drugs in Animal Models of Cancer Chemoprevention

(2011) S. M. Fischer et al.   Cancer Prevention Research

GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression

(2011) L. Yang et al.   CANCER RESEARCH

Prostaglandin E2 and T cells: friends or foes?

(2011) Vinatha Sreeramkumar et al.   IMMUNOLOGY AND CELL BIOLOGY

Expression and histopathological correlation of CCR9 and CCL25 in ovarian cancer

(2011) Shailesh Singh   INTERNATIONAL JOURNAL OF ONCOLOGY

CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion

(2011) Lillard   INTERNATIONAL JOURNAL OF ONCOLOGY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice

(2011) K. Y. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COX-2 and PGE2-dependent immunomodulation in breast cancer

(2011) Edward P. Chen et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

(2011) J. Wu et al.   Science Translational Medicine

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

S1P2, the G Protein-Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice

(2010) W. Du et al.   CANCER RESEARCH

Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts

(2010) K. Walter et al.   CLINICAL CANCER RESEARCH

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells

(2010) Nick Barker et al.   GASTROENTEROLOGY

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way

(2010) Tobias Pukrop et al.   GLIA

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival

(2010) Lin   ONCOLOGY REPORTS

Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer

(2009) Hiraku Itadani et al.   BMC GENOMICS

G 12-Mediated Pathway Promotes Invasiveness of Nasopharyngeal Carcinoma by Modulating Actin Cytoskeleton Reorganization

(2009) S.-C. Liu et al.   CANCER RESEARCH

Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis

(2009) Hideki Amano et al.   CANCER SCIENCE

Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology

(2009) Richard M. Ransohoff   IMMUNITY

New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC

(2009) Leszek Rybaczyk et al.   INFLAMMATORY BOWEL DISEASES

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration

(2009) S Su et al.   ONCOGENE

G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation

(2008) Keiji Tanese et al.   AMERICAN JOURNAL OF PATHOLOGY

Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation

(2008) Kunrong Cheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

Activation of CCR9/CCL25 in Cutaneous Melanoma Mediates Preferential Metastasis to the Small Intestine

(2008) F. F. Amersi et al.   CLINICAL CANCER RESEARCH

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE