Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs)

(2018) Tim Sonntag et al.   FEBS Journal

Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities

(2017) John D Lapek et al.   NATURE BIOTECHNOLOGY

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

(2017) Ahmet Zehir et al.   NATURE MEDICINE

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes

(2017) Fan Xing et al.   Cell Reports

Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm

(2017) Krushna C Patra et al.   Clinical and Translational Gastroenterology

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

(2016) Fabrizio Miranda et al.   CANCER CELL

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

A genetic and molecular update on adrenocortical causes of Cushing syndrome

(2016) Maya Lodish et al.   Nature Reviews Endocrinology

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability

(2016) D. R. Pattabiraman et al.   SCIENCE

PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

(2016) Coralie Drelon et al.   Nature Communications

Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation

(2016) Lorissa J. Smulan et al.   Cell Reports

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis

(2016) Mahesh S. Padanad et al.   Cell Reports

Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A

(2015) Andrea Wilderman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

GNAS R201H and Kras G12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm

(2015) K Taki et al.   ONCOGENE

Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight

(2015) Yong-Qi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

SIK2 Is Critical in the Regulation of Lipid Homeostasis and Adipogenesis In Vivo

(2014) Jinyoung Park et al.   DIABETES

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas

(2014) Eliana Amato et al.   JOURNAL OF PATHOLOGY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

(2014) Guido von Figura et al.   NATURE CELL BIOLOGY

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog−driven medulloblastoma

(2014) Xuelian He et al.   NATURE MEDICINE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

(2014) J. N. Honeyman et al.   SCIENCE

Gαs regulates the post-endocytic sorting of G protein-coupled receptors

(2014) Stéphanie Rosciglione et al.   Nature Communications

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

(2014) Kashyap Patel et al.   Nature Communications

Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

(2013) Sharon M. Louie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Pancreatic Cystic Neoplasms: Management and Unanswered Questions

(2013) James J. Farrell et al.   GASTROENTEROLOGY

Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex

(2013) Ji-Hong Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatobiliary and Pancreatic Neoplasms in Patients With McCune-Albright Syndrome

(2013) Sébastien Gaujoux et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

(2013) Eduardo Dominguez et al.   Nature Chemical Biology

Isolation, culture and genetic manipulation of mouse pancreatic ductal cells

(2013) Maximilian Reichert et al.   Nature Protocols

Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity

(2013) D. I. Benjamin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

(2012) Meredith A. Collins et al.   JOURNAL OF CLINICAL INVESTIGATION

Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila

(2012) Michael C. Wehr et al.   NATURE CELL BIOLOGY

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

(2012) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

A Hormone-Dependent Module Regulating Energy Balance

(2011) Biao Wang et al.   CELL

Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes

(2011) M. Mino-Kenudson et al.   GUT

Glycerolipid/free fatty acid cycle and islet β-cell function in health, obesity and diabetes

(2011) Marc Prentki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

(2011) J. Wu et al.   Science Translational Medicine

Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice

(2010) Julien Bricambert et al.   JOURNAL OF CLINICAL INVESTIGATION

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL