Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13

(2017) Stephanie L. Scherer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma

(2017) Vivian Chua et al.   MOLECULAR CANCER RESEARCH

Gene bivalency at Polycomb domains regulates cranial neural crest positional identity

(2017) Maryline Minoux et al.   SCIENCE

GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation

(2016) Young H. Lim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Metastatic disease from uveal melanoma: treatment options and future prospects

(2016) Richard D Carvajal et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

(2016) Jonathan M. L. Ostrem et al.   NATURE REVIEWS DRUG DISCOVERY

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer

(2015) Batoul Kaabi et al.   PATHOLOGY & ONCOLOGY RESEARCH

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Novel insights into G protein and G protein-coupled receptor signaling in cancer

(2014) Morgan O’Hayre et al.   CURRENT OPINION IN CELL BIOLOGY

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma

(2013) Katie A Matatall et al.   BMC CANCER

Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ

(2013) Matthew D. Shirley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein   subunits

(2013) P. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

(2013) Alan V. Smrcka   TRENDS IN PHARMACOLOGICAL SCIENCES

Epidemiology and Management of Uveal Melanoma

(2012) Yoshihiro Yonekawa et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Histone Deacetylase Inhibitors Induce Growth Arrest and Differentiation in Uveal Melanoma

(2011) S. Landreville et al.   CLINICAL CANCER RESEARCH

Dual-Color Click Beetle Luciferase Heteroprotein Fragment Complementation Assays

(2010) Victor Villalobos et al.   CHEMISTRY & BIOLOGY

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb–Hdm2 interaction and apoptosis

(2010) R B Delston et al.   ONCOGENE

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

Dissecting direct reprogramming through integrative genomic analysis

(2008) Tarjei S. Mikkelsen et al.   NATURE

Genome-scale DNA methylation maps of pluripotent and differentiated cells

(2008) Alexander Meissner et al.   NATURE

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Bcl-2 family proteins and cancer

(2008) K W Yip et al.   ONCOGENE