Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

(2019) Davide Malfacini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)

(2018) Richard D. Carvajal et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting G protein-coupled receptor signalling by blocking G proteins

(2018) Adrian P. Campbell et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

(2018) Michael D. Onken et al.   Science Signaling

Atypical activation of the G protein Gαq by the oncogenic mutation Q209P

(2018) Marcin Maziarz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

(2018) Dominic Lapadula et al.   MOLECULAR CANCER RESEARCH

Metastatic disease from uveal melanoma: treatment options and future prospects

(2016) Richard D Carvajal et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model

(2016) Juan Luis Callejas-Valera et al.   CARCINOGENESIS

Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

(2016) Xiao-Feng Xiong et al.   Nature Chemistry

Driver Mutations in Uveal Melanoma

(2016) Christina L. Decatur et al.   JAMA Ophthalmology

Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQQ209L-driven melanoma

(2016) B R Patel et al.   Oncogenesis

Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice

(2015) J. L.-Y. Huang et al.   CANCER RESEARCH

Two-way communication between the metabolic and cell cycle machineries: the molecular basis

(2015) Joanna Kaplon et al.   CELL CYCLE

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

(2015) Peter Johansson et al.   Oncotarget

Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP

(2014) Fa-Xing Yu et al.   CANCER CELL

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

GNAQ/11 Mutations in Uveal Melanoma: Is YAP the Key to Targeted Therapy?

(2014) Matthew G. Field et al.   CANCER CELL

Gαq signalling: The new and the old

(2014) Guzmán Sánchez-Fernández et al.   CELLULAR SIGNALLING

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

Inhibition of Mutant GNAQ Signaling in Uveal Melanoma Induces AMPK-Dependent Autophagic Cell Death

(2013) G. Ambrosini et al.   MOLECULAR CANCER THERAPEUTICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations

(2013) X Chen et al.   ONCOGENE

Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location

(2013) Joachim Goedhart et al.   Scientific Reports

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Combination Small Molecule MEK and PI3K Inhibition Enhances Uveal Melanoma Cell Death in a Mutant GNAQ- and GNA11-Dependent Manner

(2012) J. S. Khalili et al.   CLINICAL CANCER RESEARCH

Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial

(2012) Gerald S Falchook et al.   LANCET ONCOLOGY

A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors

(2012) Jose P. Vaqué et al.   MOLECULAR CELL

Genetic and molecular characterization of uveal melanoma cell lines

(2012) K. G. Griewank et al.   Pigment Cell & Melanoma Research

Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes

(2011) T. Kendall Harden et al.   CHEMICAL REVIEWS

Uveal Melanoma: Trends in Incidence, Treatment, and Survival

(2011) Arun D. Singh et al.   OPHTHALMOLOGY

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Coordinating Speed and Amplitude in G-Protein Signaling

(2008) Elliott M. Ross   CURRENT BIOLOGY

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE