Mitophagy and Oxidative Stress in Cancer and Aging: Focus on Sirtuins and Nanomaterials

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

miR-346 functions as a pro-survival factor under ER stress by activating mitophagy

(2018) Junfei Guo et al.   CANCER LETTERS

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

(2018) Paul K. Ziegler et al.   CELL

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

(2018) Liming Wang et al.   CELL RESEARCH

SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy

(2018) Jianxun Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hybrid Compounds & Oxidative Stress Induced Apoptosis In Cancer Therapy

(2018) Aysegul Hanikoglu et al.   CURRENT MEDICINAL CHEMISTRY

SIRT3 deficiency exacerbates p53/Parkin‑mediated mitophagy inhibition and promotes mitochondrial dysfunction: Implication for aged hearts

(2018) Yan Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy

(2018) Jianfeng Wang et al.   International Journal of Nanomedicine

Toxicity and mechanisms of action of titanium dioxide nanoparticles in living organisms

(2018) Jing Hou et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity

(2018) Heather N. Carter et al.   JOURNAL OF PHYSIOLOGY-LONDON

Liraglutide repairs the infarcted heart: The role of the SIRT1/Parkin/mitophagy pathway

(2018) Huiying Qiao et al.   Molecular Medicine Reports

Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy

(2018) Hongzhu Yan et al.   ONCOLOGY REPORTS

Short-Duration Swimming Exercise after Myocardial Infarction Attenuates Cardiac Dysfunction and Regulates Mitochondrial Quality Control in Aged Mice

(2018) Dajun Zhao et al.   Oxidative Medicine and Cellular Longevity

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

The Hippo pathway in normal development and cancer

(2018) Marcello Maugeri-Saccà et al.   PHARMACOLOGY & THERAPEUTICS

Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders

(2018) Asem Alageel et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma

(2018) Zhi-qiang Yao et al.   Cell Death & Disease

Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy

(2018) Ruibing Li et al.   Redox Biology

Aging aggravates hepatic ischemia-reperfusion injury in mice by impairing mitophagy with the involvement of the EIF2α-parkin pathway

(2018) Yang Li et al.   Aging-US

Mitochondrial dynamics in cancer-induced cachexia

(2018) Miranda van der Ende et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Titanium dioxide nanoparticles induce proteostasis disruption and autophagy in human trophoblast cells

(2018) Yuqing Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Disruption of the Superoxide Anions-Mitophagy Regulation Axis Mediates Copper Oxide Nanoparticles-Induced Vascular Endothelial Cell Death

(2018) Jun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

FUNDC1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation

(2018) Wenhui Li et al.   HEPATOLOGY

Nanoparticles in Daily Life: Applications, Toxicity and Regulations

(2018) Ritu Gupta et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

The ROS-Mitophagy Signalling Pathway Regulates Liver Endothelial Cell Survival during Ischaemia-Reperfusion Injury

(2018) Ricky H. Bhogal et al.   LIVER TRANSPLANTATION

High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment

(2018) Chengyong He et al.   Nanomedicine-Nanotechnology Biology and Medicine

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy

(2018) Wuzheng Zhu et al.   Cell Death & Disease

Vincristine ablation of Sirt2 induces cell apoptosis and mitophagy via Hsp70 acetylation in MDA-MB-231 cells

(2018) Fanghui Sun et al.   BIOCHEMICAL PHARMACOLOGY

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

(2018) Yanjun Li et al.   EMBO JOURNAL

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury

(2018) Qiang Li et al.   Frontiers in Neuroscience

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons

(2017) Lu Zheng et al.   HUMAN MOLECULAR GENETICS

Current applications and future prospects of nanomaterials in tumor therapy

(2017) Yu Huang et al.   International Journal of Nanomedicine

Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells

(2017) Limin Wei et al.   International Journal of Nanomedicine

Mesoporous silica nanoparticles trigger mitophagy in endothelial cells and perturb neuronal network activity in a size- and time-dependent manner

(2017) Antonina Orlando et al.   International Journal of Nanomedicine

Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells

(2017) Sunkui Ke et al.   International Journal of Nanomedicine

Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3

(2017) Sanghoon Kwon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

(2017) Bin Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into autophagosome–lysosome fusion

(2017) Shuhei Nakamura et al.   JOURNAL OF CELL SCIENCE

SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide

(2017) Ilaria Carnevale et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans

(2017) Miyuki Sato et al.   NATURE CELL BIOLOGY

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

(2017) Bin Xiao et al.   Cell Death & Disease

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Methylation of BNIP3 in pancreatic cancer inhibits the induction of mitochondrial-mediated tumor cell apoptosis

(2017) Ye Li et al.   Oncotarget

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy

(2017) Anne-Sophie Benischke et al.   Scientific Reports

Muscle immobilization activates mitophagy and disrupts mitochondrial dynamics in mice

(2016) C. Kang et al.   Acta Physiologica

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

(2016) Mohammed Dany et al.   BLOOD

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

(2016) S. Agnihotri et al.   CANCER RESEARCH

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

(2016) V E Kagan et al.   CELL DEATH AND DIFFERENTIATION

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia

(2016) MASAAKI SHIDA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Parkin Regulates the Activity of Pyruvate Kinase M2

(2016) Kun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Alterations in Mitochondrial Quality Control in Alzheimer’s Disease

(2016) Qian Cai et al.   Frontiers in Cellular Neuroscience

Sirt3-mediated mitophagy protects tumor cells against apoptosis under hypoxia

(2016) Aimin Qiao et al.   Oncotarget

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

(2016) Yongmei Qi et al.   Scientific Reports

Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria

(2015) Gabriele Di Sante et al.   AMERICAN JOURNAL OF PATHOLOGY

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

(2015) Jie Li et al.   Autophagy

SIRT5 regulation of ammonia-induced autophagy and mitophagy

(2015) Lucia Polletta et al.   Autophagy

Autophagy and oxidative stress in cardiovascular diseases

(2015) Yu Mei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitophagy induced by nanoparticle–peptide conjugates enabling an alternative intracellular trafficking route

(2015) Zhaolei Zhang et al.   BIOMATERIALS

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

(2015) Aaron N Long et al.   BMC Neurology

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

(2015) Sara Salatin et al.   CELL BIOLOGY INTERNATIONAL

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

(2015) K Palikaras et al.   CELL DEATH AND DIFFERENTIATION

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

(2015) A. H. Chourasia et al.   EMBO REPORTS

Copper nanoclusters trigger muscle cell apoptosis and atrophyin vitroandin vivo

(2015) Yayun Liu et al.   JOURNAL OF APPLIED TOXICOLOGY

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases

(2015) Dong Hyun Jo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Enhanced reactive oxygen species overexpression by CuO nanoparticles in poorly differentiated hepatocellular carcinoma cells

(2015) Mei-Lang Kung et al.   Nanoscale

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma

(2015) F Radogna et al.   ONCOGENE

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

(2015) Veikko Linko et al.   TRENDS IN BIOTECHNOLOGY

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

p62/SQSTM1 but not LC3 is accumulated in sarcopenic muscle of mice

(2015) Kunihiro Sakuma et al.   Journal of Cachexia Sarcopenia and Muscle

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

PGC-1α modulates denervation-induced mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   Skeletal Muscle

MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury

(2014) Praveen Mannam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

A critical role of superoxide anion in selenite-induced mitophagic cell death

(2014) Eun Hee Kim et al.   Autophagy

PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation

(2014) Norihiko Furuya et al.   Autophagy

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Toxicity of Nanoparticles

(2014) Maria Zoroddu et al.   CURRENT MEDICINAL CHEMISTRY

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

The vacuolar-type H+-ATPase at a glance - more than a proton pump

(2014) M. E. Maxson et al.   JOURNAL OF CELL SCIENCE

Mechanisms of nanotoxicity: Generation of reactive oxygen species

(2014) Peter P. Fu et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Pharmacokinetics of metallic nanoparticles

(2014) Zhoumeng Lin et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

A dual role for autophagy in a murine model of lung cancer

(2014) Shuan Rao et al.   Nature Communications

Sirtuins and Resveratrol-Derived Compounds: A Model for Understanding the Beneficial Effects of the Mediterranean Diet

(2014) Matteo Russo et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures

(2013) Jiang Li et al.   ADVANCED MATERIALS

The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease

(2013) T. Jayasena et al.   AGEING RESEARCH REVIEWS

Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia

(2013) Fabio Penna et al.   AMERICAN JOURNAL OF PATHOLOGY

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: Differences between primary and cancer cells

(2013) Jaganmohan Reddy Jangamreddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy

(2013) Y. Takahashi et al.   BLOOD

Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes

(2013) Anna Biason-Lauber et al.   Cell Metabolism

Sirtuins and ageing—new findings

(2013) Leonard Guarente   EMBO REPORTS

Molecular signaling toward mitophagy and its physiological significance

(2013) Du Feng et al.   EXPERIMENTAL CELL RESEARCH

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway

(2013) K.-S. Lee et al.   GENES & DEVELOPMENT

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Recent advances in Parkinson’s disease genetics

(2013) Steven Lubbe et al.   JOURNAL OF NEUROLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle

(2012) Michael F. O'Leary et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy

(2012) Ricky H. Bhogal et al.   Autophagy

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging

(2012) Debapriya Dutta et al.   CIRCULATION RESEARCH

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Inhibition of cardiomyocyte lysosomal activity in hydroxychloroquine cardiomyopathy

(2012) Andrea Frustaci et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation

(2012) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper(ii) oxide nanoparticles penetrate into HepG2 cells, exert cytotoxicity via oxidative stress and induce pro-inflammatory response

(2012) Jean-Pascal Piret et al.   Nanoscale

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

(2012) James P White et al.   Skeletal Muscle

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

Down-Regulation of Bax-Interacting Factor 1 in Human Pancreatic Ductal Adenocarcinoma

(2011) Domenico Coppola et al.   PANCREAS

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

(2010) S Michiorri et al.   CELL DEATH AND DIFFERENTIATION

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

(2009) J. M. McClung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy

(2009) Melanie Schwarten et al.   Autophagy

Expression of BNIP3 in invasive breast cancer: correlations with the hypoxic response and clinicopathological features

(2009) Esther A Koop et al.   BMC CANCER

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy: Principles and significance in health and disease

(2008) Virginia Todde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Parkin as a tumor suppressor gene for hepatocellular carcinoma

(2008) M Fujiwara et al.   ONCOGENE

Decreased expression of Bax-interacting factor-1 (Bif-1) in invasive urinary bladder and gallbladder cancers

(2008) Su Young Kim et al.   PATHOLOGY

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE