Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons
Authors
Keywords
-
Journal
HUMAN MOLECULAR GENETICS
Volume -, Issue -, Pages ddw418
Publisher
Oxford University Press (OUP)
Online
2016-12-16
DOI
10.1093/hmg/ddw418
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations
- (2016) Clément A. Gautier et al. HUMAN MOLECULAR GENETICS
- Mitochondrial Protein Quality Control: The Mechanisms Guarding Mitochondrial Health
- (2015) Iryna Bohovych et al. ANTIOXIDANTS & REDOX SIGNALING
- PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane
- (2015) Stephan Gehrke et al. Cell Metabolism
- Measuring In Vivo Mitophagy
- (2015) Nuo Sun et al. MOLECULAR CELL
- Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress
- (2015) Alicia M. Pickrell et al. NEURON
- Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling
- (2015) Riccardo Filadi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration
- (2015) Daniel A. Stevens et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria
- (2015) Brigit E. Riley et al. PLoS Genetics
- Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
- (2014) Gian-Luca McLelland et al. EMBO JOURNAL
- Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
- (2014) Konstantinos Palikaras et al. EXPERIMENTAL GERONTOLOGY
- Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase
- (2014) Nicol Birsa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MFN2 Couples Glutamate Excitotoxicity and Mitochondrial Dysfunction in Motor Neurons
- (2014) Wenzhang Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
- (2014) Lesley A. Kane et al. JOURNAL OF CELL BIOLOGY
- PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s
- (2014) Juan Carlos Corona et al. NEUROCHEMICAL RESEARCH
- Tissue- and Cell-Specific Mitochondrial Defect in Parkin-Deficient Mice
- (2014) Maria Damiano et al. PLoS One
- Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
- (2014) Kahori Shiba-Fukushima et al. PLoS Genetics
- MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
- (2014) Jina Yun et al. eLife
- Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
- (2013) Shireen A. Sarraf et al. NATURE
- Pharmacological approaches to restore mitochondrial function
- (2013) Pénélope A. Andreux et al. NATURE REVIEWS DRUG DISCOVERY
- The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
- (2013) E. S. Vincow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
- (2013) Y. Chen et al. SCIENCE
- The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease
- (2013) Eleftheria K. Pissadaki et al. Frontiers in Computational Neuroscience
- Modeling Parkinson's Disease in Primates: The MPTP Model
- (2013) G. Porras et al. Cold Spring Harbor Perspectives in Medicine
- Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons
- (2012) Qian Cai et al. CURRENT BIOLOGY
- Parkin in the regulation of fat uptake and mitochondrial biology
- (2012) Kye-Young Kim et al. CURRENT OPINION IN LIPIDOLOGY
- Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons
- (2012) Seungmin Lee et al. HUMAN MOLECULAR GENETICS
- A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset†
- (2012) Selma M. Soyal et al. HUMAN MOLECULAR GENETICS
- Sustained expression of PGC-1 in the rat nigrostriatal system selectively impairs dopaminergic function
- (2012) C. Ciron et al. HUMAN MOLECULAR GENETICS
- PINK1- and Parkin-mediated mitophagy at a glance
- (2012) Seok Min Jin et al. JOURNAL OF CELL SCIENCE
- Living on the edge with too many mouths to feed: Why dopamine neurons die
- (2012) J. Paul Bolam et al. MOVEMENT DISORDERS
- Endoplasmic reticulum–mitochondria contacts: function of the junction
- (2012) Ashley A. Rowland et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf
- (2012) Joanne Clark et al. PLoS One
- PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
- (2011) Joo-Ho Shin et al. CELL
- A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery
- (2011) Hiroyuki Katayama et al. CHEMISTRY & BIOLOGY
- The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
- (2011) Wendou Yu et al. HUMAN MOLECULAR GENETICS
- Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes
- (2011) K. N. Papanicolaou et al. MOLECULAR AND CELLULAR BIOLOGY
- Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
- (2011) F. H. Sterky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization
- (2010) Victor S. Van Laar et al. HUMAN MOLECULAR GENETICS
- Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
- (2010) Matthew E. Gegg et al. HUMAN MOLECULAR GENETICS
- Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
- (2010) Atsushi Tanaka et al. JOURNAL OF CELL BIOLOGY
- Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex
- (2010) A. Misko et al. JOURNAL OF NEUROSCIENCE
- The role of parkin in familial and sporadic Parkinson's disease
- (2010) Ted M. Dawson et al. MOVEMENT DISORDERS
- PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease
- (2010) B. Zheng et al. Science Translational Medicine
- Regulation of DNA repair by parkin
- (2009) Shyan-Yuan Kao BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mitochondrial dysfunction in Parkinson's disease
- (2009) Konstanze F. Winklhofer et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair
- (2009) Oliver Rothfuss et al. HUMAN MOLECULAR GENETICS
- Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission
- (2009) Ruben K. Dagda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease
- (2009) Julien Dusonchet et al. NEUROBIOLOGY OF DISEASE
- Oxidative stress induces degradation of mitochondrial DNA
- (2009) Inna Shokolenko et al. NUCLEIC ACIDS RESEARCH
- Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
- (2009) Suzana Gispert et al. PLoS One
- Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts
- (2008) Heather Mortiboys et al. ANNALS OF NEUROLOGY
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Mitofusin 2 tethers endoplasmic reticulum to mitochondria
- (2008) Olga Martins de Brito et al. NATURE
- Paradoxical effects of increased expression of PGC-1 on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
- (2008) C. S. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
- (2008) C. A. Gautier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The PINK1/Parkin pathway regulates mitochondrial morphology
- (2008) A. C. Poole et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
- (2008) H. Deng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started