Review
Pharmacology & Pharmacy
Yanyu Jiang, Shuaishuai Ni, Biying Xiao, Lijun Jia
Summary: This review summarizes the functions, clinical significance, and regulatory mechanisms of Ub and Ubl pathways in tumorigenesis, as well as the current progress of small-molecular drug discovery.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Mark A. Nakasone, Karolina A. Majorek, Mads Gabrielsen, Gary J. Sibbet, Brian O. Smith, Danny T. Huang
Summary: This study elucidates the mechanism of processive K48-linked polyUb chain formation by UBE2K, including acceptor Ub recognition and multivalent Ub-binding feature.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kazhaleh Mohammadi, Mahdieh Salimi, S. Abdolhamid Angaji, Arthur Saniotis, Foroozandeh Mahjoobi
Summary: This study investigated the relationship between Bif-1 gene expression levels and hormone receptor status in breast cancer patients and found that there was no significant association between Bif-1 gene expression and hormone receptors (ER, PR, and HER2).
Article
Astronomy & Astrophysics
Yu-Kuo Hsiao, Yao Yu
Summary: In the B+ -> D(+)D(-)K(+) decay, LHCb has reported the observation of open-charm exotic states with four different quark flavors, proposing a process to confirm this discovery. The estimates suggest that these states are accessible to the LHCb experiment, paving the way for further research in b-baryon decays.
Article
Pharmacology & Pharmacy
Yaoyun Niu, Yuehui Zhang, Wanqiu Zhang, Jinghua Lu, Yang Chen, Wenhui Hao, Jin Zhou, Lijun Wang, Weidong Xie
Summary: This study found that canagliflozin inhibits the activation of the NLRP3 inflammasome and inflammation by upregulating Bif-1 and autophagy in a non-hypoglycemic manner. This discovery provides new insights for the treatment of pneumonia patients with concurrent diabetes.
FRONTIERS IN PHARMACOLOGY
(2022)
News Item
Biochemistry & Molecular Biology
Sven M. Lange, Yogesh Kulathu
Summary: Different types of ubiquitin chains serve as distinct cellular signals, with the new synthetic antigen-binding fragment sAB-K29 specifically recognizing K29-linked diubiquitin and linking K29 chains to proteotoxic stress and their accumulation in midbodies during mitosis.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Vikash Chandra, Hazem Ibrahim, Clementine Halliez, Rashmi B. Prasad, Federica Vecchio, Om Prakash Dwivedi, Jouni Kvist, Diego Balboa, Jonna Saarimaki-Vire, Hossam Montaser, Tom Barsby, Vaino Lithovius, Isabella Artner, Swetha Gopalakrishnan, Leif Groop, Roberto Mallone, Decio L. Eizirik, Timo Otonkoski
Summary: The TYK2 gene is crucial in the development of type 1 diabetes. In this study, the researchers demonstrate that TYK2 regulates the development of beta-cells and inhibiting TYK2 in the islets enhances their survival against CD8(+) T-cell cytotoxicity. This finding highlights TYK2 as a potential therapeutic target to halt the progression of type 1 diabetes.
NATURE COMMUNICATIONS
(2022)
Review
Geosciences, Multidisciplinary
Franco Pirajno, Hao-Cheng Yu
Summary: This contribution explores the consistent banding of chemical sediments from Fe-rich to silica-rich associated with venting, specifically focusing on Algoma-type iron formation. The banding of these chemical sediments in terms of Fe oxides and silica reflects their unusual characteristics and potential association with sulphide-bearing mineral systems.
Review
Biochemistry & Molecular Biology
Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Circadian clocks are internal timing systems that enable organisms to adjust their behavioral and physiological rhythms to daily changes in the environment. Post-translational modifications, including ubiquitination and deubiquitination, play key roles in regulating the stability, activity, localization, and interactions of clock proteins, ultimately influencing the pace of circadian clocks and their responses to external cues.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Cameron Williams, Ken C. Dong, Connor Arkinson, Andreas Martin
Summary: AAA+ ATPase Cdc48 utilizes the cofactor Ufd1/Npl4 to bind and thread polyubiquitinated substrates for their extraction and subsequent degradation. FRET-based assays reveal the mechanisms and kinetics of ubiquitin unfolding, insertion, and substrate unfolding. Cdc48 uses Ufd1's UT3 domain to bind a K48-linked ubiquitin on the initiator's proximal side, directing it towards rapid unfolding and engagement by Cdc48. Ubiquitins on the distal side increase substrate affinity and unfolding but hinder substrate release from Cdc48-Ufd1/Npl4.
Article
Chemistry, Multidisciplinary
Huasong Ai, Zebin Tong, Zhiheng Deng, Jiakun Tian, Liying Zhang, Maoshen Sun, Yunxiang Du, Ziyu Xu, Qiang Shi, Lujun Liang, Qingyun Zheng, Jia-Bin Li, Man Pan, Lei Liu
Summary: This study describes a practical chemical synthesis of E2-Ub-nucleosome conjugates that can trap the transient intermediates of E3-mediated Ub transfer from E2 to nucleosomes. The characterization and structure determination of these complexes reveal how different E3-E2 modules establish a specific architecture to orient the Ub towards the target lysine. This work provides the first example of using a chemical trapping strategy to study E3-mediated Ub transferring mechanisms on full-length and folded proteins.
Article
Geochemistry & Geophysics
Qiming Ma, Yuqing Wang, Yile Ao, Qi Wang, Wenkai Lu
Summary: Seismic inversion aims to map low-resolution seismic data to high-resolution impedance data. Traditional methods have good interpretability, while deep learning-based methods lack interpretability. This article proposes a new deep learning model called uncertainty backpropagation network (UB-Net) that can predict impedance and epistemic uncertainty simultaneously, and it demonstrates advanced inversion accuracy on both synthetic and real examples.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Gastroenterology & Hepatology
Kishor Pant, Estanislao Peixoto, Seth Richard, Aalekhya Biswas, M. Gerard O'Sullivan, Nasra Giama, Yeonjung Ha, Jun Yin, Pietro Carotenuto, Massimiliano Salati, Yanan Ren, Rendong Yang, Brunella Franco, Lewis R. Roberts, Sergio A. Gradilone
Summary: The study revealed that SIRT1 is overexpressed in cholangiocarcinoma and plays a tumorigenic role by modulating primary cilia formation. Targeting SIRT1 may provide a potential therapeutic approach for cholangiocarcinoma.
Article
Endocrinology & Metabolism
Cheng Luo, Can Hou, Danyi Yang, Tingting Tan, Chen Chao
Summary: UC improves pancreatic beta-cell function by activating Nrf2 signaling, thereby alleviating T1D progression.
NUTRITION & DIABETES
(2023)
Article
Cell Biology
Meilin Ye, Ting Liu, Shanshan Liu, Rong Tang, Hongrui Liu, Fan Zhang, Shenglei Luo, Minqi Li
Summary: This study found elevated expression of Prdx1 in oral squamous cell carcinoma (OSCC) and demonstrated its role in promoting tumor cell proliferation and metastasis. Additionally, Prdx1 silencing increased intracellular ROS levels and activated pyroptosis.
CELL DEATH DISCOVERY
(2023)
