Synaptic Dysfunction in Alzheimer’s Disease: Aβ, Tau, and Epigenetic Alterations

Pyruvate Prevents the Inhibition of the Long-term Potentiation Induced by Amyloid-β through Protein Phosphatase 2A Inactivation

(2018) Xiaonan Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-β are Associated with Autophagic Defects in Alzheimer's Disease

(2018) Irina Lonskaya et al.   JOURNAL OF ALZHEIMERS DISEASE

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

(2017) Eleanor K. Pickett et al.   SYNAPSE

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Early effects of Aβ 1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways

(2016) Fabiana Morroni et al.   BEHAVIOURAL BRAIN RESEARCH

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

(2016) Evgenia Salta et al.   EMBO Molecular Medicine

Local and Use-Dependent Effects of β-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis

(2016) Brooke L. Sinnen et al.   JOURNAL OF NEUROSCIENCE

MicroRNA abundance is altered in synaptoneurosomes during prion disease

(2016) Amrit S. Boese et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice

(2016) Julia Hernandez-Rapp et al.   Scientific Reports

Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway

(2015) Yan-Si Xiong et al.   AGING CELL

The microRNAs Let7c and miR21 are recognized by neuronal Toll-like receptor 7 to restrict dendritic growth of neurons

(2015) Hsin-Yu Liu et al.   EXPERIMENTAL NEUROLOGY

Computational identification of epigenetically regulated lncRNAs and their associated genes based on integrating genomic data

(2015) Tingting Zhao et al.   FEBS LETTERS

Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity

(2015) Takashi Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Immunotherapy Modulates Both Pathological Tau and Upstream Amyloid Pathology in an Alzheimer's Disease Mouse Model

(2015) D. L. Castillo-Carranza et al.   JOURNAL OF NEUROSCIENCE

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

Cnga2 Knockout Mice Display Alzheimer’s-Like Behavior Abnormities and Pathological Changes

(2015) Ao-Ji Xie et al.   MOLECULAR NEUROBIOLOGY

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

(2015) Xintian You et al.   NATURE NEUROSCIENCE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons

(2015) Yu Gao et al.   STEM CELLS

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

(2015) F. F. Wagner et al.   Chemical Science

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

(2015) Josiane Budni et al.   Aging and Disease

Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers

(2015) Giovanni Lugli et al.   PLoS One

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

(2014) J. Banzhaf-Strathmann et al.   EMBO JOURNAL

MicroRNA-138 is a potential regulator of memory performance in humans

(2014) Julia Schröder et al.   Frontiers in Human Neuroscience

Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals

(2014) S. Washietl et al.   GENOME RESEARCH

microRNA-9 attenuates amyloidβ-induced synaptotoxicity by targeting calcium/calmodulin-dependent protein kinase kinase 2

(2014) FEI CHANG et al.   Molecular Medicine Reports

Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5

(2014) Ke Li et al.   MOLECULAR NEUROBIOLOGY

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

The evolution of lncRNA repertoires and expression patterns in tetrapods

(2014) Anamaria Necsulea et al.   NATURE

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

(2014) Meredith A. Chabrier et al.   NEUROBIOLOGY OF DISEASE

The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity

(2014) N. R. Smalheiser   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

MicroRNA-9 controls dendritic development by targeting REST

(2014) Sebastian A Giusti et al.   eLife

Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer’s disease

(2014) Hwan-Ching Tai et al.   Acta Neuropathologica Communications

The role of ATM and DNA damage in neurons: Upstream and downstream connections

(2013) Karl Herrup et al.   DNA REPAIR

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

(2013) Christine E. Holt et al.   NEURON

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

miR-153 Regulates SNAP-25, Synaptic Transmission, and Neuronal Development

(2013) Chunyao Wei et al.   PLoS One

Tauopathy Differentially Affects Cell Adhesion Molecules in Mouse Brain: Early Down-Regulation of Nectin-3 in Stratum Lacunosum Moleculare

(2013) Hervé Maurin et al.   PLoS One

Developmental and Activity-Dependent miRNA Expression Profiling in Primary Hippocampal Neuron Cultures

(2013) Myrrhe van Spronsen et al.   PLoS One

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Are Tau Aggregates Toxic or Protective in Tauopathies?

(2013) Catherine M. Cowan et al.   Frontiers in Neurology

Circular RNA (circRNA) in Alzheimer's disease (AD)

(2013) Walter J. Lukiw   Frontiers in Genetics

Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target

(2012) G. Shaltiel et al.   Brain Structure & Function

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

(2012) Richard Sando et al.   CELL

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation

(2012) Farzaneh Modarresi et al.   NATURE BIOTECHNOLOGY

microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons

(2012) Federico Dajas-Bailador et al.   NATURE NEUROSCIENCE

miR-212/132 expression and functions: within and beyond the neuronal compartment

(2012) A. Wanet et al.   NUCLEIC ACIDS RESEARCH

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc

(2012) Karin Wibrand et al.   PLoS One

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

(2012) J S Rao et al.   Translational Psychiatry

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

microRNA-34c is a novel target to treat dementias

(2011) Athanasios Zovoilis et al.   EMBO JOURNAL

Age-associated decrease of SIRT1 expression in rat hippocampus

(2011) Ana Quintas et al.   EXPERIMENTAL GERONTOLOGY

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Linking Amyloid-ß and Tau: Amyloid-ß Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton

(2011) Hans Zempel et al.   Neurodegenerative Diseases

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease

(2011) Marong Fang et al.   TOXICOLOGY LETTERS

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse

(2010) Erika Chung et al.   BMC NEUROSCIENCE

Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau

(2010) Dara L. Dickstein et al.   Brain Structure & Function

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

(2010) Delphine Bernard et al.   EMBO JOURNAL

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

(2010) Dieter Edbauer et al.   NEURON

Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3

(2010) M. Shioya et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

MicroRNA miR-137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb-1

(2010) Richard D. Smrt et al.   STEM CELLS

Synaptic degeneration in Alzheimer’s disease

(2009) Thomas Arendt   ACTA NEUROPATHOLOGICA

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

(2009) Xiaoying Wang et al.   BRAIN RESEARCH BULLETIN

MAPK, β-amyloid and synaptic dysfunction: the role of RAGE

(2009) Nicola Origlia et al.   Expert Review of Neurotherapeutics

Accumulation of tau induced in neurites by microglial proinflammatory mediators

(2009) Philipp Gorlovoy et al.   FASEB JOURNAL

Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo

(2009) Aaron S. Nudelman et al.   HIPPOCAMPUS

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity

(2009) Vijay Chandrasekar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling

(2009) Soren Impey et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

(2009) Gabriele Siegel et al.   NATURE CELL BIOLOGY

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

(2009) Priyamvada Rajasethupathy et al.   NEURON

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of the microRNA network cause neurodegenerative disease

(2009) Sébastien S. Hébert et al.   TRENDS IN NEUROSCIENCES

Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes

(2008) Jeffrey A. Fein et al.   AMERICAN JOURNAL OF PATHOLOGY

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

The epigenetic effects of amyloid-β1–40 on global DNA and neprilysin genes in murine cerebral endothelial cells

(2008) Kun-Lin Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

(2008) Reisuke H. Takahashi et al.   NEUROBIOLOGY OF AGING

An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP

(2008) Gary A. Wayman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA