Journal
JOURNAL OF CELL BIOLOGY
Volume 215, Issue 6, Pages 757-759Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201611177
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Funding
- National Natural Science Foundation of China [31630048, 31421002, 31561143001, 31225018, 31401184, 31671430]
- National Basic Research Program of China [2013CB910100]
- Howard Hughes Medical Institute
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The Ser/Thr kinase ULK1/Atg1 controls autophagy initiation under nutrient starvation conditions. In this issue, Nazio et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605089) demonstrate that oscillatory modulation of NEDD4L-mediated proteasomal degradation and mTOR-dependent de novo protein synthesis of ULK1 ensures the proper amplitude and duration of the autophagy response during prolonged starvation, thus maintaining cellular homeostasis.
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