Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling: Figure 1

(2013) Fei Yin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defective Leptin–AMP-Dependent Kinase Pathway Induces Nitric Oxide Release and Contributes to Mitochondrial Dysfunction and Obesity in ob/ob Mice

(2011) Paola V. Finocchietto et al.   ANTIOXIDANTS & REDOX SIGNALING

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

(2011) Huiyun Liang et al.   MUSCLE & NERVE

JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities

(2010) Sidharth Mehan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Insulin signaling meets mitochondria in metabolism

(2010) Zhiyong Cheng et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential

(2009) Kate Petersen Shay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

(2009) C.A. Grillo et al.   BRAIN RESEARCH

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

(2009) Qiongqiong Zhou et al.   FEBS LETTERS

Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production

(2009) Philip Y. Lam et al.   FREE RADICAL RESEARCH

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin and JNK: optimizing metabolic homeostasis and lifespan

(2009) Jason Karpac et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats

(2008) Gjumrakch Aliev et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS