Extracellular histones, cell-free DNA, or nucleosomes: differences in immunostimulation

Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

(2016) M Martin et al.   CELL DEATH AND DIFFERENTIATION

The Alarmin Properties of DNA and DNA-associated Nuclear Proteins

(2016) Melinda Magna et al.   CLINICAL THERAPEUTICS

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Inter-  inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury

(2015) H. Chaaban et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Septic Shock Sera Containing Circulating Histones Induce Dendritic Cell–Regulated Necrosis in Fatal Septic Shock Patients

(2015) Loic Raffray et al.   CRITICAL CARE MEDICINE

FSAP-mediated nucleosome release from late apoptotic cells is inhibited by autoantibodies present in SLE

(2015) Gerben Marsman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Proteomic Characterization of the Nucleolar Linker Histone H1 Interaction Network

(2015) Heather J. Szerlong et al.   JOURNAL OF MOLECULAR BIOLOGY

Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN

(2015) S. V. R. Kumar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular DNA and histones: double-edged swords in immunothrombosis

(2015) T. J. Gould et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophil activation and nucleosomes as markers of systemic inflammation in paroxysmal nocturnal hemoglobinuria: effects of eculizumab

(2015) S. T. A. van Bijnen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments

(2015) Kun Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of the Proinflammatory and Procoagulant Properties of Nuclear, Mitochondrial, and Bacterial DNA

(2015) Vinai C. Bhagirath et al.   SHOCK

Circulating levels of DNA-histone complex and dsDNA are independent prognostic factors of disseminated intravascular coagulation

(2015) Ji-Eun Kim et al.   THROMBOSIS RESEARCH

Association of neutrophil extracellular traps with endometriosis-related chronic inflammation

(2014) Eniko Berkes et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones in tissue injury and inflammation

(2014) Ramanjaneyulu Allam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment

(2014) Hiroki Kawano et al.   LABORATORY INVESTIGATION

Release and activity of histone in diseases

(2014) R Chen et al.   Cell Death & Disease

Serum-dependent processing of late apoptotic cells for enhanced efferocytosis

(2014) Y Y Liang et al.   Cell Death & Disease

TLR9 Activation Is Triggered by the Excess of Stimulatory versus Inhibitory Motifs Present in Trypanosomatidae DNA

(2014) Mélissa Erin Khan et al.   PLoS Neglected Tropical Diseases

Histone 3.3 Participates in a Self-Sustaining Cascade of Apoptosis That Contributes to the Progression of Chronic Obstructive Pulmonary Disease

(2013) Carlos A. Barrero et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

(2013) K. C. A. A. Wildhagen et al.   BLOOD

Histones trigger sterile inflammation by activating the NLRP3 inflammasome

(2013) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

Nucleosomes and neutrophil activation in sickle cell disease painful crisis

(2013) M. Schimmel et al.   HAEMATOLOGICA

Circulating histones exacerbate inflammation in mice with acute liver failure

(2013) Zongmei Wen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA

(2013) Cherilyn M. Sirois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury

(2013) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Human CRP Defends against the Toxicity of Circulating Histones

(2013) S. T. Abrams et al.   JOURNAL OF IMMUNOLOGY

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

(2013) Mayumi Nakahara et al.   PLoS One

Cooperation of Factor VII-Activating Protease and Serum DNase I in the Release of Nucleosomes From Necrotic Cells

(2013) Femke Stephan et al.   Arthritis & Rheumatology

Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction

(2012) Mark R. Gillrie et al.   AMERICAN JOURNAL OF PATHOLOGY

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis

(2012) Maurits L. van Montfoort et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice

(2012) G. M. Thomas et al.   BLOOD

Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies

(2012) T. A. Fuchs et al.   BLOOD

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C

(2012) Sacha Zeerleder et al.   CRITICAL CARE MEDICINE

Induction of type I IFNs by intracellular DNA-sensing pathways

(2012) Taner Cavlar et al.   IMMUNOLOGY AND CELL BIOLOGY

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular histone release in response to traumatic injury

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature

(2011) Yue Li et al.   EMBO JOURNAL

Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: Implications for systemic lupus erythematosus

(2011) Dennis Lindau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice

(2011) Hai Huang et al.   HEPATOLOGY

Microparticles as antigenic targets of antibodies to DNA and nucleosomes in systemic lupus erythematosus

(2011) Anirudh J. Ullal et al.   JOURNAL OF AUTOIMMUNITY

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

The Nucleosome (Histone-DNA Complex) Is the TLR9-Specific Immunostimulatory Component of Plasmodium falciparum That Activates DCs

(2011) Nagaraj M. Gowda et al.   PLoS One

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Functional Role of the Interaction between Polysialic Acid and Extracellular Histone H1

(2010) B. Mishra et al.   JOURNAL OF NEUROSCIENCE

CpG-containing immunostimulatory DNA sequences elicit TNF-α–dependent toxicity in rodents but not in humans

(2009) John D. Campbell et al.   JOURNAL OF CLINICAL INVESTIGATION

DNase 1 activity in patients with systemic lupus erythematosus: relationship with epidemiological, clinical, immunological and therapeutical features

(2009) F Martinez-Valle et al.   LUPUS

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Histone H1 Subtypes Differentially Modulate Chromatin Condensation without Preventing ATP-Dependent Remodeling by SWI/SNF or NURF

(2009) Jaime Clausell et al.   PLoS One

The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis

(2008) Charles F. Reich et al.   EXPERIMENTAL CELL RESEARCH

Nucleosome-releasing factor: a new role for factor VII-activating protease (FSAP)

(2008) Sacha Zeerleder et al.   FASEB JOURNAL

The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation

(2008) Tobias Haas et al.   IMMUNITY

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE