Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases

Cell-Free DNA and Active Rejection in Kidney Allografts

(2017) Roy D. Bloom et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evaluation of cell-free DNA in urine as a marker for bladder cancer diagnosis

(2017) Matelda Zancan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS

Renoprotective Effects of DNAse-I Treatment in a Rat Model of Ischemia/Reperfusion-Induced Acute Kidney Injury

(2016) Victoria Peer et al.   AMERICAN JOURNAL OF NEPHROLOGY

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes

(2016) Tineke Kraaij et al.   AUTOIMMUNITY REVIEWS

Diagnostic and prognostic potential of circulating cell-free genomic and mitochondrial DNA fragments in clear cell renal cell carcinoma patients

(2016) Hongbiao Lu et al.   CLINICA CHIMICA ACTA

Urinary circulating DNA detection for dynamic tracking of EGFR mutations for NSCLC patients treated with EGFR-TKIs

(2016) S. Chen et al.   Clinical & Translational Oncology

Urinary Mitochondrial DNA Copy Number Identifies Chronic Renal Injury in Hypertensive PatientsNovelty and Significance

(2016) Alfonso Eirin et al.   HYPERTENSION

Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome

(2016) Maria Victoria Ramos et al.   Journal of Innate Immunity

Plasma Mitochondrial DNA Level is a Prognostic Marker in Peritoneal Dialysis Patients

(2016) Cheuk-Chun Szeto et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

Myeloperoxidase anti-neutrophil cytoplasmic antibody affinity is associated with the formation of neutrophil extracellular traps in the kidney and vasculitis activity in myeloperoxidase anti-neutrophil cytoplasmic antibody-associated microscopic polyangii

(2016) Masaharu Yoshida et al.   NEPHROLOGY

Graft-Derived Cell-Free DNA as a Marker of Transplant Graft Injury

(2016) Michael Oellerich et al.   THERAPEUTIC DRUG MONITORING

Cell-Free DNA: An Upcoming Biomarker in Transplantation

(2015) E. M. Gielis et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Role of Cell-Free Plasma DNA in Critically Ill Patients with Sepsis

(2015) Anna Clementi et al.   BLOOD PURIFICATION

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

(2015) J. Cedervall et al.   CANCER RESEARCH

At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases

(2015) April Barnado et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peritoneal Cell-free DNA: an innovative method for determining acute cell damage in peritoneal membrane and for monitoring the recovery process after peritonitis

(2015) Grazia Maria Virzì et al.   JOURNAL OF NEPHROLOGY

Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9

(2015) N. Tsuji et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury

(2015) Ryan M. Whitaker et al.   KIDNEY INTERNATIONAL

Extracellular, but not intracellular HMGB1, facilitates self-DNA induced macrophage activation via promoting DNA accumulation in endosomes and contributes to the pathogenesis of lupus nephritis

(2015) Xiaoyun Li et al.   MOLECULAR IMMUNOLOGY

Importance of low serum DNase I activity and polyspecific anti-neutrophil cytoplasmic antibodies in propylthiouracil-induced lupus-like syndrome

(2015) Mirjana Gajic-Veljic et al.   RHEUMATOLOGY

Donor-Derived Cell-Free DNA Is a Novel Universal Biomarker for Allograft Rejection in Solid Organ Transplantation

(2015) J. Beck et al.   TRANSPLANTATION PROCEEDINGS

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification

(2014) Alison S. Devonshire et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Impact of extracellular RNA on endothelial barrier function

(2014) Silvia Fischer et al.   CELL AND TISSUE RESEARCH

Preconditioning with Intravenous Colitic Cell-Free DNA Prevents DSS-Colitis by Altering TLR9-Associated Gene Expression Profile

(2014) Györgyi Műzes et al.   DIGESTIVE DISEASES AND SCIENCES

Cell-free RNA content in urine as a possible molecular diagnostic tool for clear cell renal cell carcinoma

(2014) An Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Direct measurement of cell-free DNA from serially collected capillary plasma during incremental exercise

(2014) Sarah Breitbach et al.   JOURNAL OF APPLIED PHYSIOLOGY

Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING

(2014) Jeonghyun Ahn et al.   JOURNAL OF IMMUNOLOGY

Extracellular histones in tissue injury and inflammation

(2014) Ramanjaneyulu Allam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Enhanced Formation and Disordered Regulation of NETs in Myeloperoxidase-ANCA-Associated Microscopic Polyangiitis

(2014) D. Nakazawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA

(2014) Alain R Thierry et al.   NATURE MEDICINE

Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing

(2014) Rebecca W. Y. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty

(2013) Juulia Jylhävä et al.   AGING CELL

Role of Extracellular RNA in Atherosclerotic Plaque Formation in Mice

(2013) Sakine Simsekyilmaz et al.   CIRCULATION

Is plasma cell-free DNA really a useful marker for diagnosis and treatment of trauma patients?

(2013) Biqiong Ren et al.   CLINICA CHIMICA ACTA

Circulating cell free DNA: Preanalytical considerations

(2013) Safia El Messaoudi et al.   CLINICA CHIMICA ACTA

A stabilizing reagent prevents cell-free DNA contamination by cellular DNA in plasma during blood sample storage and shipping as determined by digital PCR

(2013) S.E. Norton et al.   CLINICAL BIOCHEMISTRY

High-Resolution Profiling of Fetal DNA Clearance from Maternal Plasma by Massively Parallel Sequencing

(2013) S. C. Y. Yu et al.   CLINICAL CHEMISTRY

Quantification of Plasma Cell-Free DNA1in Predicting Therapeutic Efficacy of Sorafenib on Metastatic Clear Cell Renal Cell Carcinoma

(2013) Gang Feng et al.   DISEASE MARKERS

Plasma cell-free DNA and its DNA integrity as biomarker to distinguish prostate cancer from benign prostatic hyperplasia in patients with increased serum prostate-specific antigen

(2013) Jiang Feng et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Quantitation of cell-free DNA and RNA in plasma during tumor progression in rats

(2013) Dolores C García-Olmo et al.   Molecular Cancer

Circulating bacterial-derived DNA fragments as a marker * of systemic inflammation in peritoneal dialysis

(2013) B. C.-H. Kwan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing

(2013) K. C. A. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission

(2013) Ivan Gornik et al.   RESUSCITATION

Monitoring of Plasma Cell-Free DNA in Predicting Postoperative Recurrence of Clear Cell Renal Cell Carcinoma

(2013) JingJing Wan et al.   UROLOGIA INTERNATIONALIS

Cooperation of Factor VII-Activating Protease and Serum DNase I in the Release of Nucleosomes From Necrotic Cells

(2013) Femke Stephan et al.   Arthritis & Rheumatology

Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury

(2012) Hada Macher et al.   CLINICA CHIMICA ACTA

Stabilization of cell-free RNA in blood samples using a new collection device

(2012) M. Rohan Fernando et al.   CLINICAL BIOCHEMISTRY

Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

(2012) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: The Vitality 90+ Study

(2012) Juulia Jylhävä et al.   EXPERIMENTAL GERONTOLOGY

Alterations in methylation status of immune response genes promoters in cell-free DNA during a hemodialysis procedure

(2012) Marie Korabecna et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Continuous adaptation through genetic communication – a putative role for cell-free DNA

(2012) Dimetrie L Peters et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Influence of Temperature during Transportation on Cell-Free DNA Analysis

(2012) Mats Hidestrand et al.   FETAL DIAGNOSIS AND THERAPY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Circulating cell-free DNA in hemodialysis patients predicts mortality

(2012) D. Tovbin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Increased Death of Adipose Cells, a Path to Release Cell-Free DNA Into Systemic Circulation of Obese Women

(2012) Maricela Haghiac et al.   Obesity

Total serum DNA and DNA integrity: diagnostic value in patients with hepatitis B virus-related hepatocellular carcinoma

(2012) Hui Chen et al.   PATHOLOGY

Circulating Cell-Free DNA

(2012) Sarah Breitbach et al.   SPORTS MEDICINE

Urine Cell-Free DNA integrity as a marker for early bladder cancer diagnosis: Preliminary data

(2012) Valentina Casadio et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Serum cell-free DNA in renal cell carcinoma

(2011) Michela de Martino et al.   CANCER

Short-Term Treadmill Running as a Model for Studying Cell-Free DNA Kinetics In Vivo

(2011) T. Beiter et al.   CLINICAL CHEMISTRY

Cell-Free DNA—A Marker to Predict Ischemic Brain Damage in a Rat Stroke Experimental Model

(2011) Matthew Boyko et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Cell-Free DNA as a Marker for Prediction of Brain Damage in Traumatic Brain Injury in Rats

(2011) Sharon Ohayon et al.   JOURNAL OF NEUROTRAUMA

Apoptotic cell-free DNA promotes inflammation in haemodialysis patients

(2011) J. Atamaniuk et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Universal noninvasive detection of solid organ transplant rejection

(2011) T. M. Snyder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating cell-free DNA levels correlate with postresuscitation survival rates in out-of-hospital cardiac arrest patients

(2011) Chien-Hua Huang et al.   RESUSCITATION

Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise

(2010) Johanna Atamaniuk et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Mass spectrometric based analysis, characterization and applications of circulating cell free DNA isolated from human body fluids

(2010) Vaneet K. Sharma et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Levosimendan reduces plasma cell-free DNA levels in patients with ischemic cardiomyopathy

(2010) Apostolos Zaravinos et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Quantification of Circulating Cell-Free DNA in the Serum of Patients with Obstructive Sleep Apnea–Hypopnea Syndrome

(2010) Liang Ye et al.   LUNG

Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: The Vitality 90+ study

(2010) Juulia Jylhävä et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Circulating free fetal nucleic acids in maternal plasma and preeclampsia

(2010) Barbora Vlková et al.   MEDICAL HYPOTHESES

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Assessment of Cell-Free DNA with Microvascular Complication of Type II Diabetes Mellitus, Using PCR and Elisa

(2010) Shereen A. El Tarhouny et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating cell-free DNA as a potential biomarker for minimal and mild endometriosis

(2010) Rebecca Zachariah et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Circulating mitochondrial DNA in serum: A universal diagnostic biomarker for patients with urological malignancies

(2010) Jörg Ellinger et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Cell-free DNA levels in acute myocardial infarction patients during hospitalization

(2009) A. Destouni et al.   ACTA CARDIOLOGICA

Detection of Mutated K-rasDNA in Urine, Plasma, and Serum of Patients with Colorectal Carcinoma or Adenomatous Polyps

(2009) Ying-Hsiu Su et al.   Annals of the New York Academy of Sciences

Deoxyribonuclease Activity and Circulating DNA Concentration in Blood Plasma of Patients with Prostate Tumors

(2009) Anna V. Cherepanova et al.   Annals of the New York Academy of Sciences

Cell-Free Plasma DNA during Peritoneal Dialysis and Hemodialysis and in Patients with Chronic Kidney Disease

(2009) Marie Korabecna et al.   Annals of the New York Academy of Sciences

An Improved Method for the Isolation of Free-Circulating Plasma DNA and Cell-Free DNA from Other Body Fluids

(2009) Christoph Kirsch et al.   Annals of the New York Academy of Sciences

Optimizing the yield and utility of circulating cell-free DNA from plasma and serum

(2009) Xiaoyan Xue et al.   CLINICA CHIMICA ACTA

Elevated transrenal DNA (cell-free urine DNA) in patients with urinary tract infection compared to healthy controls

(2009) Vanessa García Moreira et al.   CLINICAL BIOCHEMISTRY

Cell-Free DNA as a Noninvasive Acute Rejection Marker in Renal Transplantation

(2009) V. Garcia Moreira et al.   CLINICAL CHEMISTRY

Optimization of Transrenal DNA Analysis: Detection of Fetal DNA in Maternal Urine

(2009) E. M. Shekhtman et al.   CLINICAL CHEMISTRY

Circulating Bacterial-Derived DNA Fragments and Markers of Inflammation in Chronic Hemodialysis Patients

(2009) M. Bossola et al.   Clinical Journal of the American Society of Nephrology

Oxidative Stress-Induced Carcinogenesis and Its Prevention Guest Editor: Shinya Toyokuni Sources of Extracellular, Oxidatively-Modified DNA Lesions: Implications for Their Measurement in Urine

(2009) Marcus S. Cooke et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Plasma Cell-Free DNA Levels in Children on Peritoneal Dialysis

(2009) O. Ozkaya et al.   NEPHRON CLINICAL PRACTICE

Cell-Free Plasma DNA during Hemodialysis

(2009) Sylvie Opatrna et al.   RENAL FAILURE

Cell-free DNA in the Peritoneal Effluent of Peritoneal Dialysis Solutions

(2009) Jernej Pajek et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Prediction of Clear Cell Renal Cell Carcinoma by Integrity of Cell-free DNA in Serum

(2009) Feng Gang et al.   UROLOGY

A rapid direct fluorescent assay for cell-free DNA quantification in biological fluids

(2009) H. Goldshtein et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Release of cell-free DNA into the bloodstream leads to high levels of non-tumor plasma DNA during tumor progression in rats

(2008) Dolores C. García-Olmo et al.   CANCER LETTERS

Presence of Donor-Derived DNA and Cells in the Urine of Sex-Mismatched Hematopoietic Stem Cell Transplant Recipients: Implication for the Transrenal Hypothesis

(2008) E. C.W. Hung et al.   CLINICAL CHEMISTRY

Concentration and microsatellite status of plasma DNA for monitoring patients with renal carcinoma

(2008) Roberto A. Perego et al.   EUROPEAN JOURNAL OF CANCER

Smoking in pregnancy is associated with increased total maternal serum cell-free DNA levels

(2008) Adam C. Urato et al.   PRENATAL DIAGNOSIS

Increased cell-free DNA concentrations in patients with obstructive sleep apnea

(2008) Chol Shin et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES