From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals

Thalassaemia

(2018) Ali T Taher et al.   LANCET

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

(2017) Ramasamy Jagadeeswaran et al.   EXPERIMENTAL HEMATOLOGY

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

(2017) Babette C. Hammerling et al.   Nature Communications

Contribution of plasma membrane lipid domains to red blood cell (re)shaping

(2017) C. Leonard et al.   Scientific Reports

Hemin induces mitophagy in a leukemic erythroblast cell line

(2016) Claudio Marcelo Fader et al.   BIOLOGY OF THE CELL

A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis

(2016) F. Lupo et al.   BLOOD

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation

(2016) M. N. Gnanapragasam et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

Erythroblast enucleation is a dynein-dependent process

(2016) Isuzu Kobayashi et al.   EXPERIMENTAL HEMATOLOGY

A novel role for nuclear factor-erythroid 2 in erythroid maturation by modulation of mitochondrial autophagy

(2016) M. Gothwal et al.   HAEMATOLOGICA

E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts

(2016) Kelsey L. Swartz et al.   MOLECULAR AND CELLULAR BIOLOGY

U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3′ End Formation

(2016) Sung Mi Park et al.   MOLECULAR CELL

Erythroleukemia cells acquire an alternative mitophagy capability

(2016) Jian Wang et al.   Scientific Reports

A novel role for nuclear factor-erythroid 2 in erythroid maturation by modulation of mitochondrial autophagy

(2016) M. Gothwal et al.   HAEMATOLOGICA

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome

(2015) G. W. Magor et al.   BLOOD

Elevated erythropoietin and cytokines levels are related to impaired reticulocyte maturation in thalassemic patients

(2015) Punnee Butthep et al.   BLOOD CELLS MOLECULES AND DISEASES

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction

(2015) K.J. Ahlqvist et al.   Nature Communications

A novel role for 12/15-lipoxygenase in regulating autophagy

(2015) Alwena H. Morgan et al.   Redox Biology

Global transcriptome analyses of human and murine terminal erythroid differentiation

(2014) X. An et al.   BLOOD

The RNA in reticulocytes is not just debris: It is necessary for the final stages of erythrocyte formation

(2014) EunMi Lee et al.   BLOOD CELLS MOLECULES AND DISEASES

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes

(2014) Shinya Honda et al.   Nature Communications

Of macrophages and red blood cells; a complex love story

(2014) Djuna Z. de Back et al.   Frontiers in Physiology

Primitive and definitive erythropoiesis in mammals

(2014) James Palis   Frontiers in Physiology

Autophagy facilitates organelle clearance during differentiation of human erythroblasts

(2013) Virginie M.S. Betin et al.   Autophagy

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

(2013) S. S. Franco et al.   HAEMATOLOGICA

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

(2013) I. Barde et al.   SCIENCE

Spatiotemporally controlled induction of autophagy-mediated lysosome turnover

(2013) Yu-Hsien Hung et al.   Nature Communications

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes

(2012) Ji Zhang et al.   Autophagy

Integrated protein quality-control pathways regulate free  -globin in murine  -thalassemia

(2012) E. Khandros et al.   BLOOD

Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis

(2012) R. E. Griffiths et al.   BLOOD

A novel role for survivin in erythroblast enucleation

(2012) G. Keerthivasan et al.   HAEMATOLOGICA

Mammalian erythroblast enucleation requires PI3K-dependent cell polarization

(2012) J. Wang et al.   JOURNAL OF CELL SCIENCE

Enhanced activation of autophagy in β-thalassemia/Hb E erythroblasts during erythropoiesis

(2011) Pathrapol Lithanatudom et al.   ANNALS OF HEMATOLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Proteolipidic Composition of Exosomes Changes during Reticulocyte Maturation

(2011) Kévin Carayon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vesicle trafficking plays a novel role in erythroblast enucleation

(2010) G. Keerthivasan et al.   BLOOD

Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts

(2010) P. Ji et al.   HAEMATOLOGICA

Down-regulation of Myc Is Essential for Terminal Erythroid Maturation

(2010) Senthil Raja Jayapal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Autophagy-dependent and -independent mechanisms of mitochondrial clearance during reticulocyte maturation

(2009) Ji Zhang et al.   Autophagy

Membrane remodeling during reticulocyte maturation

(2009) J. Liu et al.   BLOOD

The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume

(2009) L. Blanc et al.   BLOOD

Mitochondrial clearance is regulated by Atg7-dependent and independent mechanisms during reticulocyte maturation

(2009) J. Zhang et al.   BLOOD

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation

(2009) Evgenya Y. Popova et al.   CHROMOSOME RESEARCH

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5q(del) clones: a single cell study

(2009) L. Garderet et al.   HAEMATOLOGICA

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PATHOPHISIOLOGY OF SICKLE CELL DISEASE AND NEW DRUGS FOR THE TREATMENT

(2009) Lucia De Franceschi   Mediterranean Journal of Hematology and Infectious Diseases

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2

(2008) Peng Ji et al.   NATURE CELL BIOLOGY