Neutrophils, G-CSF and their contribution to breast cancer metastasis

Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice

(2017) Alex N. Gordon-Weeks et al.   HEPATOLOGY

Pretreatment neutrophil-to-lymphocyte ratio is correlated with response to neoadjuvant chemotherapy as an independent prognostic indicator in breast cancer patients: a retrospective study

(2016) Yi Chen et al.   BMC CANCER

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer

(2016) Maria Rosaria Galdiero et al.   INTERNATIONAL JOURNAL OF CANCER

Pembrolizumab in Patients With Advanced Triple-Negative Breast Cancer: Phase Ib KEYNOTE-012 Study

(2016) Rita Nanda et al.   JOURNAL OF CLINICAL ONCOLOGY

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation

(2016) Thomas Welte et al.   NATURE CELL BIOLOGY

Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF

(2016) Tsuguhide Takeshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

The neutrophil lymphocyte ratio is associated with breast cancer prognosis: an updated systematic review and meta-analysis

(2016) Bajin Wei et al.   OncoTargets and Therapy

Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco

(2016) Marek Z. Wojtukiewicz et al.   Advances in Clinical and Experimental Medicine

Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

(2016) A. Spiegel et al.   Cancer Discovery

Priming of neutrophils toward NETosis promotes tumor growth

(2016) Mélanie Demers et al.   OncoImmunology

Neutrophil/Lymphocyte ratio has no predictive or prognostic value in breast cancer patients undergoing preoperative systemic therapy

(2015) Christoph Suppan et al.   BMC CANCER

A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities

(2015) Jean E. Abraham et al.   BMC Medicine

Utility of pre-treatment neutrophil–lymphocyte ratio and platelet–lymphocyte ratio as prognostic factors in breast cancer

(2015) C-H Koh et al.   BRITISH JOURNAL OF CANCER

Neutrophils: important contributors to tumor progression and metastasis

(2015) Agnieszka Swierczak et al.   CANCER AND METASTASIS REVIEWS

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

(2015) Adam Blaisdell et al.   CANCER CELL

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Type IIFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

(2015) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

(2015) Amy-Jo Casbon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The significance of G-CSF expression and myeloid-derived suppressor cells in the chemoresistance of uterine cervical cancer

(2015) Mahiru Kawano et al.   Scientific Reports

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Prognostic value of neutrophil-to-lymphocyte ratio in breast cancer

(2015) Jie Chen et al.   FEBS Open Bio

G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer

(2015) Maija Hollmén et al.   OncoImmunology

G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration

(2014) K T Morris et al.   BRITISH JOURNAL OF CANCER

BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity

(2014) Y. Cao et al.   CANCER RESEARCH

CD56brightPerforinlow Noncytotoxic Human NK Cells Are Abundant in Both Healthy and Neoplastic Solid Tissues and Recirculate to Secondary Lymphoid Organs via Afferent Lymph

(2014) P. Carrega et al.   JOURNAL OF IMMUNOLOGY

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor

(2014) A. Swierczak et al.   Cancer Immunology Research

Hematopoietic cytokines as tumor markers in breast malignancies. A multivariate analysis with ROC curve in breast cancer patients

(2013) S Ławicki et al.   Advances in Medical Sciences

Serum Levels of G-CSF and IL-7 in Iranian Breast Cancer Patients

(2013) Elahe Bordbar et al.   Asian Pacific Journal of Cancer Prevention

Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer

(2013) J Kumar et al.   BRITISH JOURNAL OF CANCER

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunomonitoring and prognostic relevance of neutrophils in clinical trials

(2013) Frede Donskov   SEMINARS IN CANCER BIOLOGY

Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells

(2012) Juntao Wang et al.   CANCER BIOLOGY & THERAPY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation

(2011) Erin M. Bekes et al.   AMERICAN JOURNAL OF PATHOLOGY

Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer

(2011) Yunwei Han et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment

(2011) Shawn Rose et al.   CYTOMETRY PART A

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

(2011) Emilie Mamessier et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2011) Jeremy D. Waight et al.   PLoS One

Meta-analysis of neutropenia or leukopenia as a prognostic factor in patients with malignant disease undergoing chemotherapy

(2010) Kohei Shitara et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung

(2010) H. H. Yan et al.   CANCER RESEARCH

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages

(2010) A. A. Filardy et al.   JOURNAL OF IMMUNOLOGY

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1

(2009) Carina Strell et al.   EXPERIMENTAL CELL RESEARCH

Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma

(2009) Hanne Krogh Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY