NETosis in Cancer – Platelet–Neutrophil Crosstalk Promotes Tumor-Associated Pathology

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

(2016) C. Alfaro et al.   CLINICAL CANCER RESEARCH

NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation

(2016) Charlotte Thålin et al.   THROMBOSIS RESEARCH

Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4

(2015) P. Prakash et al.   BLOOD

P-selectin promotes neutrophil extracellular trap formation in mice

(2015) J. Etulain et al.   BLOOD

PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock

(2015) K. Martinod et al.   BLOOD

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

(2015) J. Cedervall et al.   CANCER RESEARCH

PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling

(2015) Jyaysi Desai et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo

(2015) Bartomeu Colom et al.   IMMUNITY

Human Neutrophils Use Different Mechanisms To KillAspergillus fumigatusConidia and Hyphae: Evidence from Phagocyte Defects

(2015) Roel P. Gazendam et al.   JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease

(2015) Bart Cortjens et al.   JOURNAL OF PATHOLOGY

Neutrophil ageing is regulated by the microbiome

(2015) Dachuan Zhang et al.   NATURE

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

(2015) Siu Ling Wong et al.   NATURE MEDICINE

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Virus-Induced NETs – Critical Component of Host Defense or Pathogenic Mediator?

(2015) Craig N. Jenne et al.   PLoS Pathogens

Recognition of Aspergillus fumigatus Hyphae by Human Plasmacytoid Dendritic Cells Is Mediated by Dectin-2 and Results in Formation of Extracellular Traps

(2015) Flávio V. Loures et al.   PLoS Pathogens

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

(2015) Giselle A. Funchal et al.   PLoS One

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis

(2014) M. Koupenova et al.   BLOOD

β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps

(2014) Martin J. Raftery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

(2013) Konstantinos Kambas et al.   ANNALS OF THE RHEUMATIC DISEASES

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Platelets: bridging hemostasis, inflammation, and immunity

(2013) C. N. Jenne et al.   International Journal of Laboratory Hematology

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

A proposed role for neutrophil extracellular traps in cancer immunoediting

(2013) Sivan Berger-Achituv et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2012) Harald F. Langer et al.   CIRCULATION RESEARCH

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

(2012) Konstantinos Kambas et al.   PLoS One

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases

(2012) Jason S. Knight et al.   Frontiers in Immunology

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4

(2011) Julie S. Lefebvre et al.   ARTHRITIS AND RHEUMATISM

The relationship between tissue factor and cancer progression: insights from bench and bedside

(2011) Y. W. van den Berg et al.   BLOOD

Doubts concerning the recently reported human neutrophil lifespan of 5.4 days

(2011) P. S. Tofts et al.   BLOOD

Tumor-Associated Neutrophils: New Targets for Cancer Therapy

(2011) A. D. Gregory et al.   CANCER RESEARCH

Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent

(2011) Matteo Bianchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Efficient phagocytosis of periodontopathogens by neutrophils requires plasma factors, platelets and TLR2

(2011) A. ASSINGER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection

(2011) Saskia Hemmers et al.   PLoS One

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Cancer and renal insufficiency results of the BIRMA study

(2010) N Janus et al.   BRITISH JOURNAL OF CANCER

Circulating soluble CD40 ligand mediates the interaction between neutrophils and platelets in acute coronary syndrome

(2010) Budi Y. Setianto et al.   HEART AND VESSELS

Neutrophils: Cinderella of innate immune system

(2010) V. Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Extracellular Fibrils of Pathogenic Yeast Cryptococcus gattii Are Important for Ecological Niche, Murine Virulence and Human Neutrophil Interactions

(2010) Deborah J. Springer et al.   PLoS One

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of Chronic Kidney Disease in Cancer Patients: Lessons From the IRMA Study Group

(2010) Vincent Launay-Vacher   SEMINARS IN NEPHROLOGY

Platelet CD40L at the interface of adaptive immunity

(2010) Bennett D. Elzey et al.   THROMBOSIS RESEARCH

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Platelet–leucocyte aggregates form in the mesenteric vasculature in patients with ulcerative colitis

(2009) Peter M. Irving et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases

(2008) J. M. van Gils et al.   JOURNAL OF LEUKOCYTE BIOLOGY